2014, Número 3
<< Anterior Siguiente >>
An Med Asoc Med Hosp ABC 2014; 59 (3)
Neurocisticercosis y epilepsia
San-Juan OD, Rodríguez ZE, Gómez GGJ, Vázquez GR, Tabera TPM, Fleury A
Idioma: Español
Referencias bibliográficas: 50
Paginas: 212-218
Archivo PDF: 194.93 Kb.
RESUMEN
La neurocisticercosis humana es reconocida como un problema de salud pública, siendo considerada como la parasitosis más frecuente del sistema nervioso central. En México, la neurocisticercosis constituye la principal causa de epilepsia de inicio en el adulto. Las formas de presentación clínica son variadas; la epilepsia constituye una de las formas más comunes de instalación clínica y su frecuencia va desde el 60 al 90%. Las crisis epilépticas ocurren aproximadamente en 80% de los pacientes con neurocisticercosis y pueden aparecer durante todas las fases de la neurocisticercosis, siendo la transición coloidal la más epileptogénica. El tipo de crisis está relacionado con el número y la localización de los parásitos. La precisión diagnóstica y su clasificación está frecuentemente limitada por los recursos de neuroimagen y neurofisiología. El tratamiento de la epilepsia sintomática se encuentra basado en los lineamientos generales para el manejo de la epilepsia, sin considerar sus particularidades. El objetivo de esta revisión es mostrar los aspectos clínicos, clasificación, fisiopatología, diagnóstico y tratamiento de la epilepsia secundaria a neurocisticercosis. Actualmente, se carece de información sobre el pronóstico a largo plazo, los mecanismos epileptogénicos subyacentes, la eficacia y seguridad de los nuevos antiepilépticos, incluyendo algunos de primera generación.
REFERENCIAS (EN ESTE ARTÍCULO)
Flisser A. Neurocysticercosis in Mexico. Parasitol Today. 1988; 4 (5): 131-137.
Sotelo J, Del Brutto OH. Brain cysticercosis. Arch Med Res. 2000; 31 (1): 3-14.
Fleury A, Gomez T, Alvarez I, Meza D, Huerta M, Chavarria A et al. High prevalence of calcified silent neurocysticercosis in a rural village of Mexico. Neuroepidemiology. 2003; 22 (2): 139-145.
Andrade-Filho Ade S, Figueroa LF, Andrade-Souza VM. Clinical tomographic correlations of 220 patients with neurocisticercosis, Bahia, Brazil. Braz J Infect Dis. 2007; 11 (1): 114-117.
Winkler AS, Schaffert M, Schmutzhard E. Epilepsy in resource-poor countries-suggestion of an adjusted classification. Epilepsia. 2007; 48 (5): 1029-1030.
Placencia M, Sander JW, Roman M, Madera A, Crespo F, Cascante S et al. The characteristics of epilepsy in a largely untreated population in rural Ecuador. J Neurol Neurosurg Psych. 1994; 57 (3): 320-325.
Asadi-Pooya AA, Sperling MR. Strategies for surgical treatment of epilepsies in developing countries. Epilepsia. 2008; 49 (3): 381-385.
Del Brutto OH. Neurocysticercosis. Curr Opin Neurol. 1997; 10 (3): 268-272.
San-Juan D. Clinical manifestations of neurocysticercosis. Neurologia. 2009; 24 (5): 331-335.
Medina MT, Rosas E, Rubio Donnadieu F, Sotelo J. Neurocysticercosis as the main cause of late-onset epilepsy in Mexico. Arch Internal Med. 1990; 150 (2): 325-327.
Burneo JG, Del Brutto O, Delgado-Escueta AV, Gonzalez AE, Medina MT, Montano SM et al. Workshop report: developing an international collaborative research network in neurocisticercosis and epilepsy. Epilepsia. 2009; 50 (5): 1289-1290.
Singh G, Bawa J, Chinna D, Chaudhary A, Saggar K, Modi M et al. Association between epilepsy cysticercosis and toxocariasis: a population-based case-control study in a slum in India. Epilepsia. 2012; 53 (12): 2203-2208.
Ong S, Talan DA, Moran GJ, Mower W, Newdow M, Tsang VC et al. Neurocysticercosis in radiographically imaged seizure patients in US emergency departments. Emerg Infect Dis. 2002; 8 (6): 608-613.
Nicoletti A, Bartoloni A, Sofia V, Bartalesi F, Chavez JR, Osinaga R et al. Epilepsy and neurocysticercosis in rural Bolivia: a population-based survey. Epilepsia. 2005; 46 (7): 1127-1132.
Monteiro L, Nunes B, Mendonca D, Lopes J. Spectrum of epilepsy in neurocysticercosis: a long-term follow-up of 143 patients. Acta Neurol Scand. 1995; 92 (1): 33-40.
Nash TE, Del Brutto OH, Butman JA, Corona T, Delgado-Escueta A, Duron RM et al. Calcific neurocysticercosis and epileptogenesis. Neurology. 2004; 62 (11): 1934-1938.
Garcia-Noval J, Moreno E, de Mata F, Soto de Alfaro H, Fletes C, Craig PS et al. An epidemiological study of epilepsy and epileptic seizures in two rural Guatemalan communities. Ann Trop Med Parasitol. 2001; 95 (2): 167-175.
Nash TE, Pretell J, Garcia HH. Calcified cysticerci provoke perilesional edema and seizures. Clin Infect Dis. 2001; 33 (10): 1649-1653.
Del Brutto OH, Santibañez R, Noboa CA, Aguirre R, Diaz E, Alarcón TA. Epilepsy due to neurocysticercosis: analysis of 203 patients. Neurology. 1992; 42 (2): 389-392.
Escobar A, Nieto D. Cysticercosis. In: Minkler J, editor. The pathology of nervous system. New York: McGraw-Hill; 1972. pp. 2507-2515.
Carpio A, Escobar A, Hauser WA. Cysticercosis and epilepsy: a critical review. Epilepsia. 1998; 39 (10): 1025-1040.
Nash TE, Patronas NJ. Edema associated with calcified lesions in neurocysticercosis. Neurology. 1999; 53 (4): 777-781.
Nash TE, Pretell EJ, Lescano AG, Bustos JA, Gilman RH, González AE et al. Cysticercosis Working Group in Peru. Perilesional brain oedema and seizure activity in patients with calcified neurocysticercosis: a prospective cohort and nested case-control study. Lancet Neurol. 2008; 7 (12): 1099-1105.
Stringer JL, Marks LM, White AC Jr, Robinson P. Epileptogenic activity of granulomas associated with murine cysticercosis. Exp Neurol. 2003; 183 (2): 532-536.
Montano SM, Villaran MV, Ylquimiche L, Figueroa JJ, Rodriguez S, Bautista CT et al. Neurocysticercosis: association between seizures, serology, and brain CT in rural Peru. Neurology. 2005; 65 (2): 229-233.
Gupta M, Agarwal P, Khwaja GA, Chowdhury D, Sharma B, Bansal J et al. Randomized prospective study of outcome of short-term antiepileptic treatment in small single enhancing CT lesion in brain. Neurol India. 2002; 50 (2): 145-147.
Pradhan S, Kathuria MK, Gupta RK. Perilesional gliosis and seizure outcome: a study based on magnetization transfer magnetic resonance imaging in patients with neurocysticercosis. Ann Neurol. 2000; 48 (2): 181-187.
De Souza A, Nalini A, Koovor JM, Yeshraj G, Siddalingaiah HS, Thennarasu K. Perilesional gliosis around solitary cerebral parenchymal cysticerci and long-term seizure outcome: a prospective study using serial magnetization transfer imagen. Epilepsia. 2011; 52 (10): 1918-1927.
Chandra PS, Bal C, Garg A, Gaikwad S, Prasad K, Sharma BS et al. Surgery for medically intractable epilepsy due to post infectious etiologies. Epilepsia. 2010; 51 (6): 1097-2100.
Chung CK, Lee SK, Chi JG. Temporal lobe epilepsy caused by intrahippocampal calcified cysticercus: a case report. J Korean Med Sci. 1998; 13 (4): 445-448.
Leite JP, Terra-Bustamante VC, Fernandes RM, Santos AC, Chimelli L, Sakamoto AC et al. Calcified neurocysticercotic lesions and postsurgery seizure control in temporal lobe epilepsy. Neurology. 2000; 55 (10): 1485-1491.
Rathore C, Thomas B, Kesavadas C, Radhakrishnan K. Calcified neurocysticercosis lesions and hippocampal sclerosis: potential dual pathology? Epilepsia. 2012; 53 (4): 60-62.
Singhi P, Dayal D, Khandelwal N. One week versus four weeks of albendazole therapy for neurocysticercosis in children: a randomized, placebo-controlled double blind trial. Pediatr Infect Dis J. 2003; 22 (3): 268-272.
Cukiert A, Puglia P, Scapolan HB, Vilela MM, Marino JR. Congruence of the topography of intracranial calcifications and epileptic foci. Arq Neuropsiquiatr. 1994; 52 (3): 289-294.
Fauser S, Schulze-Bonhage A. Epileptogenicity of cortical dysplasia in temporal lobe dual pathology: an electrophysiological study with invasive recordings. Brain. 2006; 129 (1): 82-95.
Rajsherkhar V. Jeyaseelan L. Seizure outcome in patients with a solitary cerebral cysticercus granuloma. Neurology. 2004; 62 (12): 2236-2240.
Scott RA, Lhatoo SD, Sander JW. The treatment of epilepsy in developing countries: where do we go from here? Bull World Health Organ. 2001; 79 (4): 344-351.
Kwan P, Brodie MJ. Epilepsy after the first drug fails: substitution or add-on? Seizure. 2000; 9 (7): 464-468.
De Souza, A, Thennarasu K, Yeshraj G, Kovoor JM, Nalini A. Randomized controlled trial of albendazole in new-onset epilepsy and MRI-confirmed solitary cerebral cysticercal lesion: effect on long-term seizure outcome. J Neurol Sci. 2009; 276 (1-2): 108-114.
Thussu A, Chattopadhyay A, Sawhney IM, Khandelwal N. Albendazole therapy for single small enhancing CT lesions (SSECTL) in the brain in epilepsy. J Neurol Neurosurg Psych. 2008; 79 (3): 272-275.
French JA, Kanner AM, Bautista J, Abou-Khalil B, Browne T, Harden CL et al. Efficacy and tolerability of the new antiepileptic drugs I: treatment of new onset epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Neurology. 2004; 62 (8): 1252-1260.
Schuele SU, Lüders HO. Intractable epilepsy: management and therapeutic alternatives. Lancet Neurol. 2008; 7 (6): 514-524.
Serrano-Castro PJ, Sánchez-Alvarez JC, Cañadillas-Hidalgo FM, Galán-Barranco JM, Moreno-Alegre V, Mercadé-Cerdá JM et al. Consensus clinical practice guidelines of the Sociedad Andaluza de Epilepsia for the diagnosis and treatment of patients with their first epileptic seizure in emergencies. Rev Neurol. 2009; 48 (1): 39-50.
Noval JG, Sánchez AL, Allan JC. Taenia Solium Taeniasis and cysticercosis in Central America. In: Singh G, Prabhakar S, editors. Taenia solium cysticercosis: from basic to clinical science. India: CABI Pub; 2002. pp. 91-100.
Verma A, Misra S. Outcome of short-term antiepileptic treatment in patients with solitary cerebral cysticercus granuloma. Acta Neurol Scand. 2006; 113 (3): 174-177.
Kaushal S, Rani A, Chopra SC, Singh G. Safety and efficacy of clobazam versus phenytoin-sodium in the antiephiletic treatment of solitary cysticercus granuloma. Neurol India. 2006; 54 (2): 157-161.
Singh G, Rajshekhar V, Murthy JM, Prabhakar S, Modi M, Khandelwal N et al. A diagnostic and therapeutic scheme for a solitary cysticercus granuloma. Neurology. 2010; 75 (24): 2236-2245.
Bittencourt PR. Gracia CM, Martins R, Fernandes AG, Diekmann HW, Jung W. Phenytoin and carbamazepine decreased oral bioavailability of praziquantel. Neurology. 1992; 42 (3): 492-496.
Singh G, Burneo JG, Sander JW. From seizures to epilepsy and its substrates: Neurocysticercosis. Epilepsia. 2013; 54 (5): 783-792.
Gogia S, Talukdar B, Choudhury V, Arora BS. Neurocysticercosis in children: clinical findings and response to albendazole therapy in a randomized, double-blind, placebo-controlled trial in newly diagnosed cases. Trans R Soc Trop Med Hyg. 2003; 97 (4): 416-421.