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2019, Number 3

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Rev Odont Mex 2019; 23 (3)

Histological parameters of bone guided regeneration with FOULA hydroxyapatite in biou: Wistar rats

Pineda V, Olivares O, Yépez J, González A

Language: Spanish
References: 24
Page: 149-158
PDF size: 306.54 Kb.


ABSTRACT

Guided bone regeneration is a procedure to induce the regeneration of bone defects using biomaterials such as hydroxyapatite (HA), platelet concentrates, lyophilized bone, among others. In the Faculty of Dentistry at the University of the Andes (FOULA) in Venezuela, an HA-based biomaterial whose efficacy had not yet been evaluated in vivo was synthesized. Objective: To determine the effectiveness of FOULAHA in guided bone regeneration of bone defects created in tibia bones of BIOU: Wistar rats. Methodology: 33 male rats (BIOU: Wistar strain) were selected. A bone defect was created in both back tibias, the biomaterial being inserted only in the right tibia. Two experimental groups of 15 animals each were formed per type of HA (FOULA and coralline); in turn, these groups were divided into subgroups of 5 animals each according to study time (3, 6 and 9 weeks). The data were evaluated by histopathology. Results: The levels reached were level III of RO (HA-FOULA) and level II (HA-Coral). At 6 and 9 weeks, the percentage of RO, using HA-Coral, increased to level IV. However, statistically no significant differences were observed between the groups. Conclusion: FOULA HA was effective for BR in defects created in tibias of BIOU: Wistar rats.


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