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ISSN 1561-3011 (Electronic)

2018, Number 4

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Rev Cubana Invest Bioméd 2018; 37 (4)

Cistatin C series as a marker of early renal damage in diabetic subjects type 2

García EDM, Valdés CA, Zurita DFÁ, García BR

Language: Spanish
References: 41
Page: 1-14
PDF size: 283.08 Kb.


ABSTRACT

Introduction: The early identification of deterioration of renal function is key in diabetic patients. Recent studies show that serum cystatin C could be an indicator of incipient glomerular injury more sensitive than serum creatinine in this group of subjects.
Objective: To evaluate serum cystatin C as a marker of early renal damage in subjects with type 2 diabetes mellitus.
Methods: 48 subjects with diabetes mellitus type 2 were studied, divided into two groups according to the urinary excretion of albumin. Group 1 consisted of normoalbuminuric subjects (albuminuria ˂ 30 mg / 24 hrs), 2 of those with albuminuria between 30-300mg / 24hrs and normal renal function. All subjects underwent clinical history and sampling by venous puncture for glycosylated hemoglobin, creatinine and serum cystatin C (quantitative determination by immunoturbidimetry), in addition, the excretion of albumin in 24-hour urine and the glomerular filtration rate were determined. estimated by the Cockcroft and Gault formula.
Results: Cystatin C and serum creatinine were significantly higher in group 2 subjects. The sensitivity and diagnostic accuracy of cystatin C was better than the glomerular filtration rate estimated by the Cockcroft and Gault formula. Serum cystatin C showed a significant correlation with serum creatinine and glomerular filtration rate, but no correlation with 24-hour urinary albuminuria.
Conclusions: Serum cystatin C is an alternative marker, more adequate than serum creatinine for the estimation of the glomerular filtration rate in subjects with type 2 diabetes mellitus.


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