2018, Number 3
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Ortho-tips 2018; 14 (3)
Aseptic loosening in total knee arthroplasty
Reyes PV
Language: Spanish
References: 35
Page: 116-123
PDF size: 152.16 Kb.
ABSTRACT
Total knee arthroplasty (TKR) is the surgical procedure indicated in advanced gonarthrosis, with a success rate of about 90%. Aseptic loosening (AL) is currently the fourth cause of early failure in TKR requiring revision surgery. The physiopathology of aseptic loosening is developed mainly by microparticles and detritus of polyethylene and cement that generate an inflammatory reaction, causing osteolysis and subsequent loosening. The causes of aseptic loosening have fallen into three main categories: factors inherent to the patient, factors of the implant and factors related to the surgical technique. The majority of patients with TKR and osteolysis remain asymptomatic until implant failure, and there is no diagnostic study that allows early diagnosis of aseptic loosening with certainty. Improvements in the quality, manufacturing, handling and sterilization means of polyethylene have reduced the incidence of aseptic loosening in the last 20 years from 40% to 4% today. The gold standard for treatment is surgical; a revision surgery is indicated, which requires an adequate planning for the replacement and increases for implant fixation based on the degree of osteolysis according to the Anderson Orthopaedic Research Institute (AORI) classification. Traditionally, bone defects AORI 2B and 3 have been managed with structural allografts; however, the results have been variable. Currently, the use of augmentations with tantalum cones has given good results in solving bone defects, favoring osseointegration and eliminating problems associated with allografts.
REFERENCES
Le DH, Goodman SB, Maloney WJ, et al. Current modes of failure in TKA: infection, instability and stiffness predominate. Clin Orthop Relat Res. 2014; 472: 2197-2200.
Callahan CM, Drake BG, Heck DA, et al. Patient outcomes following tricompartmental total knee replacement: a meta-analysis. JAMA. 1994; 271: 1349-1357.
Gonzalez MH, Mekhail AO. The failed total knee arthroplasty: evaluation and etiology. J Am Acad Orthop Surg. 2004;12: 436-446.
Jacobs JJ, Roebuck KA, Archibeck M. Osteolysis: basic science. Clin Orthop Relat Res. 2001; 393: 71-77.
Naudie DJ, Ammen DJ, Engh GA, et al. Wear and osteolysis around total knee arthroplasty. J Am Acad Orthop Surg. 2007; 15: 53-64.
Scuderi GR. Complications after total knee arthroplasty. How to manage patients with osteolysis. J Bone Joint Surg Am. 2011; 93: 2126-2135.
Maloney W, Rosenberg A. What is the outcome of treatment for osteolysis? J Am Acad Orthop Surg. 2008; 16 (Suppl 1): S26-S32.
Fehring TK, Murphy JA, Hayes TD, et al. Factors influencing wear and osteolysis in press fit condylar modular total knee replacements. Clin Orthop Relat Res. 2004; 428: 40-50.
Oral E, Malhi AS, Wannomae KK, et al. Highly cross-linked ultrahigh molecular weight polyethylene with improved fatigue resistance for total joint arthroplasty: recipient of the 2006 Hap Paul Award. J Arthroplasty. 2008; 23: 1037-1044.
Fisher J, McEwen HM, Tipper JL, et al. Wear, debris, and biologic activity of cross-linked polyethylene in the knee: benefits and potential concerns. Clin Orthop Relat Res. 2004; 428: 114-119.
Kremers HM, Sierra RJ, Schleck CD, et al. Comparative survivorship of different tibial designs in primary total knee arthroplasty. J Bone Joint Surg Am. 2014; 96 (14): e121.
Kim YH, Park JW, Kim JS. High-flexion total knee arthroplasty: survivorship and prevalence of osteolysis. J Bone Joint Surg Am. 2012; 94: 1377-1384.
Chalmers PN, Walton D, Sporer SM, et al. Evaluation of the role for synovial aspiration in the diagnosis of aseptic loosening after total knee arthroplasty. J Bone Joint Surg Am. 2015; 97: 1597-1603.
Krebs VE, Malkani AL, Ulrich SD, et al. Complications of knee arthroplasty. En: Mont MA, Tanzer M, American Academy of Orthopaedic Surgeons. Orthopaedic knowledge update: hip and knee reconstruction 5. Am Ac Orthop Surg. 2017, pp. 233-266.
Lombardi AV, Ellison BS, Berend KR. Polyethylene wear is influenced by manufacturing technique in modular TKA. Clin Orthop Relat Res 2008; 466: 2798-2805.
Engh CA, Sychterz CJ, Young AM, et al. Interobserver and intraobserver variability in radiographic assessment of osteolysis. J Arthroplasty. 2002; 17: 752-759.
Suarez J, Griffin W, Springer B, et al. Why do revision knee arthroplasties fail? J Arthroplasty. 2008; 23 (suppl 1): 99-103.
Sharkey PF, Hozack WJ, Rothman RH, et al. Insall Award Paper: Why are total knee arthroplasties failing today? Clin Orthop Relat Res. 2002; 404: 7-13.
Pecora JR, Hinckel BB, Demange MK, et al. Interobserver correlation in classification of bone loss in total knee arthroplasty. Acta Orthop Bras. 2011; 19 (6): 368-372.
Malchau H, Potter HG. How are wear-related problems diagnosed and what forms of surveillance are necessary? J Am Acad Ortho Surg. 2008; 16 (Suppl 1): S14-S19.
Saleh KJ, Thongtrangan I, Schwartz EM. Osteolysis. Medical and surgical approaches. Clin Orthop Rel Res. 2004; 427: 138-147.
Parks NL, Engh GA, Topoleski LD, et al. The Coventry Award: Modular tibial insert micromotion: a concern with contemporary knee implants. Clin Orthop Relat Res. 1998; 356: 10-15.
Stulberg BN, Gonzalez-DellaValle A. What are the guidelines for the surgical and nonsurgical treatment of periprosthetic osteolysis? J Am Acad Ortho Surg. 2008; 16 (Suppl 1): S20-S25.
Rao AR, Engh GA, Collier MB, et al. Tibial interface wear in retrieved total knee components and correlations with modular insert motion. J Bone Joint Surg Am. 2002; 84-A: 1849-1855.
Callaghan JJ, O’rourke MR, Saleh KJ. Why knees fail: lessons learned. J Arthroplasty. 2004; 19 (Suppl 1): 31-34.
Denis DA, Komistek RD. Mobile-bearing total knee arthroplasty: design factors in minimizing wear. Clin Orthop Relat Res. 2006; 452: 70-77.
Meftah M, Ranawat AS, Ranawat CS. Ten-year follow-up of a rotating-platform, posterior-stabilized total knee arthroplasty. J Bone Joint Surg Am. 2012; 94: 426-132.
Font-Rodriguez DE, Scuderi GR, Insall JN. Survivorship of cemented total knee arthroplasty. Clin Orthop Relat Res. 1997; 345: 79-86.
Engh GA, Ammeen DJ. Classification and preoperative radiographic evaluation: knee. Orthop Clin North Am. 1998; 29 (2): 205-217.
Kim YH, Yoon SH, Kim JS. The long-term results of simultaneous fixed-bearing and mobile-bearing total knee replacements performed in the same patient. J Bone Joint Surg Br. 2007; 89 (10): 1317-1323.
Cheng T, Pan X, Liu T, Zhang X. Tibial component designs in primary total knee arthroplasty: should we reconsider all-polyethylene component? Knee Surg Sports Traumatol Arthrosc. 2012; 20 (8): 1438-1449.
Abdel MP, Morrey ME, Jensen MR, et al. Increased long-term survival of posterior cruciate-retaining versus posterior cruciate-stabilizing total knee replacements. J Bone Joint Surg Am. 2011; 93: 2072-2078.
Rand JA, Trousdale RT, Ilstrup DM, et al. Factors affecting the durability of primary total knee prostheses. J Bone Joint Surg Am. 2003; 85: 259-265.
Wimmer MA, Laurent MP, Haman JD, et al. Surface damage versus tibial polyethylene insert conformity. Clin Orthop Relat Res. 2012; 470: 1814-1825.
Sköldenberg O, Rysinska A, Eisler T, et al. Denosumab for treating periprosthetic osteolysis; study protocol for a randomized, double-blind, placebo-controlled trial. BMC Musculoskelet Disord. 2016; 17: 174.