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2006, Number 1

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Bioquimia 2006; 31 (1)

Oxidative stress as a risk factor for the development of diabetes mellitus, osteoartritis or arterial hypertension in elderly

Beristain-Pérez AS, Sánchez-Rodríguez MA, Ruiz-Ramos M, Mendoza-Núñez VM

Language: Spanish
References: 47
Page: 13-22
PDF size: 95.40 Kb.


ABSTRACT

It has been reported that oxidative stress (OxS) is a risk factor for the development of some chronic-degenerative diseases (CDD) during aged; however the scientific evidences are not conclusive. The aim of this study was to determine the influence of the OxS as a risk factor for type 2 diabetes mellitus (DM), arterial hypertension (AH) or osteoarthritis (OA) in elderly. A cross-sectional and comparative study was carried out in 162 older people: 33 with DM, 40 with AH, 26 with OA and 63 healthy subjects. Plasma lipoperoxide levels, oxidative DNA damage, red blood cell SOD and GPx activities, total antioxidant status, SOD/GPx ratio and antioxidant gap (GAP), were determined like OxS biological markers. The data were analyzed through of variance analysis and odds ratio (OR). The results showed that the elderly with AH or DM had higher OxS, characterized by higher DNA oxidative damage linked to lower GPx activity, than healthy or OA subjects, and the OxS is a risk factor for CDD with an OR of 2.45 (CI95% 1.11-5.40, p = 0.025). Our finds suggest that the OxS is a risk factor for CDD, mainly for DM and AH.


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