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2014, Number 4

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Rev Elec Psic Izt 2014; 17 (4)

Effects of the extinction in multiple contexts on the renewal of conditioned compensatory responses to ethanol

Cordero RJM, López GVM, Bonfante CRA

Language: Spanish
References: 35
Page: 1622-1647
PDF size: 669.63 Kb.


ABSTRACT

Considering that drug addiction can be explained as a result of pavlovian learning, it is regarded that the context of drug administration is involved in the elicitation of conditioned compensatory responses which causes tolerance and withdrawal symptoms, contributing to the maintenance of addiction and the appearance of relapses. Findings indicate that if a conditioned response is acquired in one context and extinguished in a different one, when the subjects are exposed to the acquisition context, renewal of conditioned responses will occur. The aim of this study was to determine the effects of extinction in multiple contexts on the renewal of conditioned compensatory responses to ethanol, in mice. It was found evidence of the appearance of conditioned compensatory responses and conditioned tolerance, the renewal of tolerance and attenuation of renewal by extinction in multiple contexts.


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