2016, Number 5
Manifestaciones cutáneas en enfermedad inflamatoria intestinal
Language: Spanish
References: 52
Page: 622-630
PDF size: 279.00 Kb.
ABSTRACT
Inflammatory bowel disease (IBD), mainly chronic unspecific ulcerative colitis and Crohn’s disease have increased in incidence in the last decades. These have multiple extraintestinal manifestations, with those of the skin appearing after the intestinal clinical presentation. These are classified as: granulomatous dermatosis, reactive dermatosis, and those secondary to treatment of IBD, and other dermatosis. This article presents the pathogenesis, clinical approach, treatment and expected evolution of these manifestations.REFERENCES
Orholm M, Munkholm P, Langholz E, Nielsen OH, Sørensen TI, Binder V. Familial occurrence of inflammatory bowel disease. N Engl J Med. 1991;324(2):84-8. Tabla 4. Manifestaciones cutáneas secundarias a medicamentos Medicamento Dermatosis secundarias Anti-TNF Granuloma anular, dermatitis reaccional medicamentosa, vasculitis leucocitoclástica, LES, psoriasis, lesiones eccematosas, carcinoma escamocelular o linfoma de células T o B10,16,51. Azatioprina Dermatitis reaccional medicamentosa, urticaria, angioedema, prurito o carcinoma escamocelular16,52. Ciclosporina Hiperplasia gingival, acné, verrugas virales, hiperplasias sebáceas, púrpura, vasculitis leucocitoclástica, carcinoma escamocelular o linfoma16,25. Esteroides Infección cutánea, reacción acneiforme, atrofia, telangiectasias, estrías, redistribución de la grasa o hipertricosis10,16,25. 6-mercaptopurina Alopecia, hiperpigmentación de piel y uñas, úlceras de mucosa oral o carcinoma escamocelular16,52. Metotrexato Úlceras en mucosa oral y piel, NET, acné, onicolisis, fototoxicidad, pseudolinfoma o carcinoma escamocelular16. Sulfasalazina/ Mesalazina/ Sulfapiridina Liquen plano, urticaria, vasculitis16.