medigraphic.com
ISSN 0016-3813 (Print)

2016, Number S2

<< Back Next >>

Gac Med Mex 2016; 152 (S2)

Serum levels of vitamin D in systemic lupus erythematosus patients (SLE) and their relationship with disease activity: longitudinal study

García-Carrasco M, Mendoza-Pinto C, Ayón-Aguilar J, Soto-Santillán P, Rodríguez-Gallegos A, Escamilla-Márquez MA, Méndez-Martínez S

Language: Spanish
References: 36
Page: 32-37
PDF size: 106.61 Kb.


ABSTRACT

Objective: To determine changes over time of serum levels of 25-hydroxy vitamin D (25(OH)D) in Mexican patients with SLE and their relationship with disease activity. Materials and methods: Longitudinal and observational study. Women with SLE were included. Serum levels of 25(OH)D were measured at baseline and after two years; the disease activity was measured with MEX-SLEDAI. Patients with initial suboptimal levels of 25(OH)D received supplements or increased doses of calcitriol. Results: 105 women with SLE were included, mean age 49.4 ± 11 years. Serum levels of 25(OH)D were higher at two years (baseline 20 ± 6.8 vs. follow-up ± 7.7; p = ‹ 0.001). There were no differences between disease activity scores at baseline and two years (baseline 1.7 ± 1.9 vs. follow-up 1.1 ± 1.7; p = 0.7). Serum levels of 25(OH)D did not correlate with disease activity during the follow up, p = 0.7. No correlation was found between changes in MEX-SLEDAI scores and serum levels of 25(OH)D, p = 0.87. Conclusion: Mexican women with SLE had increased serum levels of 25(OH)D. No correlation between serum levels of 25(OH)D and disease activity was found.


REFERENCES

  1. Lim SS, Drenkard C. Epidemiology of systemic lupus erythematosus: capturing the butterfly. Curr Rheumatol Rep. 2008;10:265-72.

  2. Tsokos GC. Systemic lupus erythematosus. N Engl J Med. 2011;365:2110-21.

  3. Katsiari CG, Liossis SN, Sfikakis PP. The pathophysiologic role of monocytes and macrophages in systemic lupus erythematosus: a reappraisal. Semin Arthritis Rheum. 2010;39:491-503.

  4. Fransen JH, van der Vlag J, Ruben J, Adema GJ, Berden JH, Hilbrands LB. The role of dendritic cells in the pathogenesis of systemic lupus erythematosus. Arthritis Res Ther. 2010;12:207.

  5. Smith CK, Kaplan MJ. The role of neutrophils in the pathogenesis of systemic lupus erythematosus. Curr Opin Rheumatol. 2015;27:448-53.

  6. Lisnevskaia L, Murphy G, Isenberg D. Systemic lupus erythematosus. Lancet. 2014;384:1878-88.

  7. Feld J, Isenberg D. Why and how should we measure disease activity and damage in lupus? Presse Med. 2014;43:151-6.

  8. Christakos S, Dhawan P, Verstuyf A, Verlinden L, Carmeliet G. Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects. Physiol Rev. 2016;96:365-408.

  9. Wei R, Christakos S. Mechanisms Underlying the Regulation of Innate and Adaptive Immunity by Vitamin D. Nutrients. 2015;7:8251-60.

  10. Adorini L, Penna G. Induction of tolerogenic dendritic cells by vitamin D receptor agonists. Handb Exp Pharmacol. 2009:251-73.

  11. Peelen E, Knippenberg S, Muris AH, et al. Effects of vitamin D on the peripheral adaptive immune system: a review. Autoimmun Rev. 2011;10:733-43.

  12. Clifford J, Rosen MD. Vitamin D insufficiency. N Engl J Med. 2011;364: 248-54.

  13. Ruiz-Irastorza G, Egurbide MV, Olivares N, Martnez-Berriotxoa, Aguirre C. Vitamin D deficiency in systemic lupus erythematosus: prevalence, predictors and clinical consequences. Rheumatology (Oxford) 2008;47: 920-3.

  14. Hamza RT, Awwad KS, Ali MK, Hamed AI. Reduced serum concentrations of 25-hydroxy vitamin D in Egyptian patients with systemic lupus erythematosus: relation to disease activity. Med Sci Monit. 2011;17:CR711-8.

  15. Thudi A, Yin S, Wandstrat AE, Li QZ, Olsen NJ. Vitamin D levels and disease status in Texas patients with systemic lupus erythematosus. Am J Med Sci. 2008;335(2):99-104.

  16. Borba VZ, Vieira JG, Kasamatsu T, Radominski SC, Sato EI, Lazaretti- Castro M. Vitamin D deficiency in patients with active systemic lupus erythematosus. Osteoporos Int. 2009;20:427-33.

  17. Sumethkul K, Boonyaratavej S, Kitumnuaypong T, et al. The predictive factors of low serum 25-hydroxyvitamin D and vitamin D deficiency in patients with systemic lupus erythematosus. Rheumatol Int. 2013;33:1461-7.

  18. Schneider L, Dos Santos AS, Santos M, da Silva Chakr RM, Monticielo OA. Vitamin D and systemic lupus erythematosus: state of the art. Clin Rheumatol. 2014;33:1033-8.

  19. García-Carrasco M, Romero JL. Vitamin D and autoimmune rheumatic disease. Reumatol Clin. 2015;11:333-4.

  20. Sundström P, Salzer J. Vitamin D and multiple sclerosis-from epidemiology to prevention. Acta Neurol Scand. 2015;132:5661.

  21. Abou-Raya A, Abou-Raya S, Helmii M. The effect of vitamin D supplementation on inflammatory and hemostatic markers and disease activity in patients with systemic lupus erythematosus: a randomized placebocontrolled trial. J Rheumatol. 2013;40:265-72.

  22. Reynolds JA, Haque S, Berry JL, et al. 25-Hydroxyvitamin D deficiency is associated with increased aortic stiffness in patients with systemic lupus erythematosus. Rheumatology (Oxford). 2012;51:544-51.

  23. Mandal M, Tripathy R, Panda AK, et al. Vitamin D levels in Indian systemic lupus erythematosus patients: association with disease activity index and interferon alpha. Arthritis Res Ther. 2014;16:R49.

  24. Mok C, Birmingham D, Ho L, Hebert L, Song H, Rovin B. Vitamin D deficiency as marker for disease activity and damage in systemic lupus erythematosus: a comparison with anti-dsDNA and anti-C1q. Lupus. 2012;21:36-42.

  25. Aranow C, Kamen DL, Dall’Era M, et al. Randomized, double-blind, placebo-controlled trial of the effect of vitamin D3 on the interferon signature in patients with systemic lupus erythematosus. Arthritis Rheumatol. 2015;67(7):1848-57

  26. Petri M, Bello KJ, Fang H, Magder LS. Vitamin D in systemic lupus erythematosus: modest association with disease activity and the urine protein-to-creatinine ratio. Arthritis Rheum. 2013;65:1865-71.

  27. Ruiz-Irastorza G, Gordo S, Olivares N, Egurbide MV, Aguirre C. Changes in vitamin D levels in patients with systemic lupus erythematosus: Effects on fatigue, disease activity, and damage. Arthritis Care Res (Hoboken). 2010;62:1160-5.

  28. Galarza-Maldonado C, Kourilovitch MR, Molineros JE, et al. The administration of low doses of rituximab followed by hydroxychloroquine, prednisone and low doses of mycophenolate mofetil is an effective therapy in Latin American patients with active systemic lupus erythematosus. Autoimmun Rev. 2010;10:108-11.

  29. Grossman JM, Gordon R, Ranganath VK, et al. American College of Rheumatology 2010 recommendations for the prevention and treatment of glucocorticoid-induced osteoporosis. Arthritis Care Res (Hoboken). 2010;62:1515-26.

  30. Schneider L, Colar da Silva AC, Werres Junior LC, et al. Vitamin D levels and cytokine profiles in patients with systemic lupus erythematosus. Lupus. 2015;24:1191-7.

  31. Andreoli L, Dall’Ara F, Piantoni S, et al. A 24-month prospective study on the efficacy and safety of two different monthly regimens of vitamin D supplementation in pre-menopausal women with systemic lupus erythematosus. Lupus. 2015;24:499-506.

  32. Mok CC, Birmingham DJ, Leung HW, Hebert LA, Song H, Rovin BH. Vitamin D levels in Chinese patients with systemic lupus erythematosus: relationship with disease activity, vascular risk factors and atherosclerosis. Rheumatology (Oxford). 2012;51:644-52.

  33. Lertratanakul A, Wu P, Dyer A, et al. 25-hydroxyvitamin D and cardiovascular disease in patients with systemic lupus erythematosus: data from a large international inception cohort .Arthritis Care Res (Hoboken). 2014;66:1167-76.

  34. Kiani AN, Fang H, Magder LS, Petri M. Vitamin D deficiency does not predict progression of coronary artery calcium, carotid intima-media thickness or high-sensitivity C-reactive protein in systemic lupus erythematosus. Rheumatology (Oxford). 2013;52:2071-6.

  35. Clark P, Vivanco-Muñoz N, Piña JT, et al. High prevalence of hipovitaminosis D in Mexican aged 14 years and older and its correlation with parathyroid hormone. Arch Osteoporos. 2015;10:225.

  36. Yap, KS, Morand EF. Vitamin D and systemic lupus erythematosus: continued evolution. Int J Rheum Dis. 2015;18:242-9.




2020     |     www.medigraphic.com