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2016, Número S2

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Gac Med Mex 2016; 152 (S2)


Influencia del género en la presentación clínica y enfermedades asociadas en adultos con enfermedad celíaca (EC)

Rubio-Tapia A, Jansson-Knodell CL, Rahim MW, See JA, Murray JA

Idioma: Español
Referencias bibliográficas: 36
Paginas: 38-46
Archivo PDF: 140.27 Kb.


RESUMEN

Introducción: La EC se diagnostica más frecuentemente en mujeres. Objetivos: El objetivo fue investigar la influencia del género en: 1) la edad al diagnóstico, 2) la presentación clínica y 3) la prevalencia de enfermedades asociadas. Métodos: La información clínica fue extraída del expediente médico electrónico en adultos con EC confirmada con biopsia intestinal. Resultados: La cohorte consistió en 385 enfermos (mujeres, 71%). Las mujeres fueron diagnosticadas a una edad más temprana (mujeres, 46.1 años; hombres, 52.6 años; p = 0.001). La prevalencia de los siguientes síntomas fue más alta en las mujeres: náuseas/vómitos (mujeres, 31%; hombres, 16%; p = 0.001), constipación (mujeres, 21%; hombres, 10%; p = 0.007) y malestar general/fatiga (mujeres, 43%; hombres, 33%; p = 0.06). Heces con grasa fueron reportadas más frecuentemente en hombres (mujeres, 11%; hombres, 22%; p = 0.006). Enfermedades autoinmunes asociadas fueron más frecuentes en mujeres (mujeres, 37%; hombres, 23%; p = 0.006). La depresión, la osteoporosis y la fibromialgia también predominaron en mujeres. Conclusiones: Nuestros resultados sugieren que hay diferencias de género clínicamente relevantes en adultos con EC que deben tomarse en cuenta al tratar al enfermo celíaco.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. Fasano A, Berti I, Gerarduzzi T, et al. Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study. Arch Intern Med. 2003;163:286-92.

  2. Murray JA, Van Dyke C, Plevak MF, Dierkhising RA, Zinsmeister AR, Melton LJ, 3rd. Trends in the identification and clinical features of celiac disease in a North American community, 1950-2001. Clin Gastroenterol Hepatol. 2003;1:19-27.

  3. Rampertab SD, Pooran N, Brar P, Singh P, Green PH. Trends in the presentation of celiac disease. Am J Med. 2006;119:355 e9-14.

  4. Shah S, Leffler D. Celiac disease: an underappreciated issue in women’s health. Womens Health (Lond). 2010;6:753-66.

  5. Zugna D, Richiardi L, Akre O, Stephansson O, Ludvigsson JF. A nationwide population-based study to determine whether coeliac disease is associated with infertility. Gut. 2010;59:1471-5.

  6. Gasbarrini A, Torre ES, Trivellini C, De Carolis S, Caruso A, Gasbarrini G. Recurrent spontaneous abortion and intrauterine fetal growth retardation as symptoms of coeliac disease. Lancet. 2000;356:399-400.

  7. Khashan AS, Henriksen TB, Mortensen PB, et al. The impact of maternal celiac disease on birthweight and preterm birth: a Danish population- based cohort study. Hum Reprod. 2010;25:528-34.

  8. Ludvigsson JF, Montgomery SM, Ekbom A. Celiac disease and risk of adverse fetal outcome: a population-based cohort study. Gastroenterology. 2005;129:454-63.

  9. Ciacci C, Cirillo M, Auriemma G, Di Dato G, Sabbatini F, Mazzacca G. Celiac disease and pregnancy outcome. Am J Gastroenterol. 1996; 91:718-22.

  10. Green PH, Cellier C. Celiac disease. N Engl J Med. 2007;357:1731-43.

  11. Bai D, Brar P, Holleran S, Ramakrishnan R, Green PH. Effect of gender on the manifestations of celiac disease: evidence for greater malabsorption in men. Scand J Gastroenterol. 2005;40:183-7.

  12. Ciacci C, Cirillo M, Sollazzo R, Savino G, Sabbatini F, Mazzacca G. Gender and clinical presentation in adult celiac disease. Scand J Gastroenterol. 1995;30:1077-81.

  13. Bardella MT, Fredella C, Saladino V, et al. Gluten intolerance: genderand age-related differences in symptoms. Scand J Gastroenterol. 2005; 40:15-9.

  14. Zugna D, Richiardi L, Akre O, Stephansson O, Ludvigsson JF. Celiac disease is not a risk factor for infertility in men. Fertil Steril. 2011;95:1709- 1713.e1-3.

  15. Hallert C, Granno C, Grant C, et al. Quality of life of adult coeliac patients treated for 10 years. Scand J Gastroenterol. 1998;33:933-8.

  16. Hallert C, Sandlund O, Broqvist M. Perceptions of health-related quality of life of men and women living with coeliac disease. Scand J Caring Sci. 2003;17:301-7.

  17. Oberhuber G. Histopathology of celiac disease. Biomed Pharmacother. 2000;54:368-72.

  18. Ogden CL, Fryar CD, Carroll MD, Flegal KM. Mean body weight, height, and body mass index, United States 1960-2002. Adv Data. 2004;(347): 1-17.

  19. McDowell MA, Fryar CD, Hirsch R, Ogden CL. Anthropometric reference data for children and adults: U.S. population, 1999-2002. Adv Data. 2005;(361):1-5.

  20. Green PHR, Stavropoulos SN, Panagi SG, et al. Characteristics of adult celiac disease in the USA: results of a national survey. Am J Gastroenterol. 2001;96:126-31.

  21. Talley NJ, Valdovinos M, Petterson TM, Carpenter HA, Melton LJ, 3rd. Epidemiology of celiac sprue: a community-based study. Am J Gastroenterol. 1994;89:843-6.

  22. Catassi C, Kryszak D, Louis-Jacques O, et al. Detection of celiac disease in primary care: a multicenter case-finding study in North America. Am J Gastroenterol. 2007;102:1454-60.

  23. Murray JA, Watson T, Clearman B, Mitros F. Effect of a gluten-free diet on gastrointestinal symptoms in celiac disease. Am J Clin Nutr. 2004;79:669-73.

  24. Midhagen G, Hallert C. High rate of gastrointestinal symptoms in celiac patients living on a gluten-free diet: controlled study. Am J Gastroenterol. 2003;98:2023-6.

  25. Talley NJ, Zinsmeister AR, Melton LJ, 3rd. Irritable bowel syndrome in a community: symptom subgroups, risk factors, and health care utilization. Am J Epidemiol. 1995;142:76-83.

  26. Corazziari E. Definition and epidemiology of functional gastrointestinal disorders. Best Pract Res Clin Gastroenterol. 2004;18:613-31.

  27. Siniscalchi M, Iovino P, Tortora R, et al. Fatigue in adult coeliac disease. Aliment Pharmacol Ther. 2005;22:489-94.

  28. Cosnes J, Cellier C, Viola S, et al. Incidence of autoimmune diseases in celiac disease: protective effect of the gluten-free diet. Clin Gastroenterol Hepatol. 2008;6:753-8.

  29. Ventura A, Magazzu G, Greco L. Duration of exposure to gluten and risk for autoimmune disorders in patients with celiac disease. SIGEP Study Group for Autoimmune Disorders in Celiac Disease. Gastroenterology. 1999;117:297-303.

  30. Viljamaa M, Kaukinen K, Huhtala H, Kyronpalo S, Rasmussen M, Collin P. Coeliac disease, autoimmune diseases and gluten exposure. Scand J Gastroenterol. 2005;40:437-43.

  31. Sategna Guidetti C, Solerio E, Scaglione N, Aimo G, Mengozzi G. Duration of gluten exposure in adult coeliac disease does not correlate with the risk for autoimmune disorders. Gut. 2001;49:502-5.

  32. Jacobson DL, Gange SJ, Rose NR, Graham NM. Epidemiology and estimated population burden of selected autoimmune diseases in the United States. Clin Immunol Immunopathol. 1997;84:223-43.

  33. Rubio-Tapia A, Murray JA. Celiac disease beyond the gut. Clin Gastroenterol Hepatol. 2008;6:722-3.

  34. Hallert C, Derefeldt T. Psychic disturbances in adult coeliac disease. I. Clinical observations. Scand J Gastroenterol. 1982;17:17-9.

  35. Ciacci C, Iavarone A, Mazzacca G, De Rosa A. Depressive symptoms in adult coeliac disease. Scand J Gastroenterol. 1998;33:247-50.

  36. Ludvigsson JF, Reutfors J, Osby U, Ekbom A, Montgomery SM. Coeliac disease and risk of mood disorders - a general population-based cohort study. J Affect Disord. 2007;99:117-26.




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