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2016, Número S2

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Gac Med Mex 2016; 152 (S2)


Niveles séricos de vitamina D en pacientes con lupus eritematoso sistémico (LES) y su asociación con la actividad de la enfermedad: estudio longitudinal

García-Carrasco M, Mendoza-Pinto C, Ayón-Aguilar J, Soto-Santillán P, Rodríguez-Gallegos A, Escamilla-Márquez MA, Méndez-Martínez S

Idioma: Español
Referencias bibliográficas: 36
Paginas: 32-37
Archivo PDF: 106.61 Kb.


RESUMEN

Objetivo: determinar las modificaciones en el tiempo de los niveles séricos de 25 hidroxivitamina D (25(OH)D) en pacientes mexicanas con LES y su relación con la actividad de la enfermedad. Material y métodos: estudio observacional y longitudinal. Se incluyeron mujeres con diagnóstico de LES. Se determinaron los niveles de 25(OH)D basales y a dos años de seguimiento, así como la actividad de la enfermedad con la variante mexicana del Systemic Lupus Erythematosus Disease Activity Index (MEX-SLEDAI). En las pacientes con niveles no óptimos de 25(OH)D en la determinación basal se suplementó o aumentó la dosis de calcitriol. Resultados: se incluyeron 105 pacientes con LES, edad media 49.4 ± 11 años. Los niveles séricos de 25(OH)D se incrementaron (basal 20 ± 6.8 ng/ml vs. seguimiento 22.7 ± 7.7; p = ‹ 0.001). No hubo diferencias en la actividad de la enfermedad (basal 1.7 ± 1.9 puntos vs. 1.1 ± 1.7 puntos; p = 0.7). Los niveles séricos de 25(OH)D en el seguimiento no se correlacionaron con actividad de la enfermedad, p = 0.7. Tampoco hubo correlaciones entre la variación del puntaje MEX-SLEDAI y los niveles 25(OH)D, p = 0.87. Conclusión: las mujeres mexicanas con LES tuvieron un incremento de niveles séricos de 25(OH)D. No se observó relación entre niveles de 25(OH)D y la actividad de la enfermedad.


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