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Academia Mexicana de Neurología, A.C.

2014, Number 4

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Rev Mex Neuroci 2014; 15 (4)

Relation ship between viral infection, cytokines and neurodevelopment

Dzib-Goodin A, Sanders L

Language: Spanish
References: 77
Page: 218-223
PDF size: 107.82 Kb.


ABSTRACT

Different lines of research indicate an association between viral infections peri- and postnatally and neurodevelopmental disorders, which can be manifested through different degrees of cognitive and mental disorders depending of the period that infection was acquired, the intensity of the attack and the response of the immune system of the host. Studies with animal models indicate that systemic infections or activation of immune response can cause changes in brain function, these changes can affect the structure and function of the central nervous system, which the literature suggests that immune alterations, especially natural inflammatory response must be considered while are making diagnoses children with neurodevelopmental disorders, especially if they show risk factors.Viruses that have been documented with greater emphasis is HHV-1 and HHV-6 of the family of herpes viruses, enteroviruses including polio and enterovirus 71, and of course HIV, while the less documented is the human parechovirus, same that produce a response from the immune system and can alter brain function in the short, medium or long term. Meanwhile Borna virus disease, has been used in animal models.This article focuses specifically on those infections caused by viral agents, with a systematic review of the literature in the area of neurovirology that seeks to describe the relationship between the presence of a virus, the subsequent expression of pro and anti inflammatory cytokines and the impact on the development of the central nervous system, a relationship that some point to cause different alterations in the mental health area.


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