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ISSN 0188-9796 (Print)

2005, Number 3

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Rev Endocrinol Nutr 2005; 13 (3)

Feasible therapeutic use of the embryonic stem cells as fountain of pancreatic β cells

Díaz F, Velasco I, Camacho-Arroyo I

Language: Spanish
References: 59
Page: 132-139
PDF size: 104.47 Kb.


ABSTRACT

Pluripotent embryonic stem (ES) cells can differentiate into all intraembryonic cells types. They are derived from the inner cell mass of pre-implantation embryos called blastocysts. ES cells can be grown undifferentiated in culture for extended periods of time with genetic stability. These pluripotent cells could become a useful source for cells aimed for cell replacement therapies in people, because of the above-mentioned characteristics. ES cells also represent a valuable model system to study in detail developmental processes and cell function. Thus, ES cells have recently gained a lot of interest in Medicine as well as in Biology. In this review, we summarize methods for the differentiation of mouse and human ES cells to progeny that synthesize and release insulin, and their effect upon grafting in animal models of type I Diabetes.


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