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ISSN 0188-9796 (Impreso)

2005, Número 3

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Rev Endocrinol Nutr 2005; 13 (3)


Posible uso terapéutico de las células troncales embrionarias como fuente de células β pancreáticas

Díaz F, Velasco I, Camacho-Arroyo I

Idioma: Español
Referencias bibliográficas: 59
Paginas: 132-139
Archivo PDF: 104.47 Kb.


RESUMEN

Las células troncales embrionarias (CTE) son células pluripotentes, es decir, mantienen la capacidad para diferenciarse a todos los tejidos que forman un embrión. Las CTE son obtenidas de la masa celular interna de un estadío embrionario muy temprano denominado blastocisto. Las CTE pueden ser mantenidas y expandidas como células indiferenciadas por grandes períodos de tiempo en cultivo, sin sufrir alteraciones genéticas. Estas células pluripotentes se han propuesto como una fuente potencial de células para terapias de reemplazo sustitutivo en el humano, debido a las características antes mencionadas. Las CTE pueden ser utilizadas también como un modelo novedoso para estudiar en detalle los procesos de desarrollo y función en el organismo. Así, las CTE han llamado poderosamente la atención en los campos de la medicina y la biología. En este trabajo de revisión nos enfocamos en describir la diferenciación de CTE de ratón y de humano a células que producen y secretan insulina, y el efecto que tiene su trasplante en modelos animales de diabetes dependiente de insulina (tipo I).


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