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2012, Number 4

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Enf Infec Microbiol 2012; 32 (4)

Impact of the QuickVue test during influenza contingency in the General Hospital Number 4 Ciudad del Carmen, Campeche 2009

Zúñiga CIR, Lozano JC, Rodríguez REJ

Language: Spanish
References: 15
Page: 134-138
PDF size: 152.24 Kb.


ABSTRACT

BACKGROUND. Rapid tests are now widely available to assist the diagnosis of influenza; implementation may optimize the use of antiviral and antibiotic agents in the clinical management of influenza.
OBJECTIVE. To determine the diagnostic utility of the rapid test for detection of influenza type A and B during the influenza contingency in the General Hospital of Zone No. 4 in the period from May 1 to December 14, 2009.
METHODOLOGY. A validation study of diagnostic test QuickVue Influenza A + B Test to analyze their usefulness for diagnosis in patients with influenza-like illness meeting the operational definition issued in the Clinical Practice Guidelines issued by the Mexican Institute for Social Security.
RESULTS. From May 1 to December 14, 2009 we conducted rapid test for influenza with their respective confirmatory test, 258 in total were taken: 35 (13.56%) tests were not confirmed; 16 (6.20%) negative tests were confirmed by RT-PCR; 10 (4%) were confirmed positive tests; 179 (69.37%) were negative. Sensitivity of test was 22.22% (10/45), and specificity of 91.79% (179/195). The positive predictive value was 38.46% (10/26) and negative predictive value 83.64% (179/214).
CONCLUSIONS. The rapid test was abnormal in 22.22% of influenza cases and normal in 91.79% of the cases that ultimately had other respiratory diseases. This means that in 38.46% of the patients who underwent rapid testing, the presence of influenza was finally confirmed, while the flu was not detected in 83.64% of cases, where other respiratory diseases occurred.



REFERENCES

  1. “Plan Institucional de Preparación y Respuesta ante Una epidemia de Influenza”. Instituto Mexicano del Seguro Social. Dirección de Prestaciones Médicas. Unidad de Salud Pública. Septiembre 2009.

  2. “Lineamientos de vigilancia epidemiológica y de laboratorio para Influenza: Sistema de Vigilancia Epidemiológica de Influenza (SISVEFLU)”. Secretaría de Salud, 20 de agosto de 2009.

  3. Novel Swine-Origin Influenza A (H1N1) Virus Investigation Team. “Emergence of a Novel Swine-Origin Influenza A (H1N1) Virus in Humans”. N Engl J Med. 2009; 360: 2605–15.

  4. Ginocchio, CC; Zhang, F; Manji, R; Arora, S; Bornfreund, M; Falk, L et al. “Evaluation of multiple test methods for the detection of the novel 2009 Influenza A (H1N1) during the New York City outbreak”. J Clin Virol. 2009; 45: 191–5.

  5. Drexler, JF; Helmer, A; Kirberg, H; Reber, U; Panning, M; Müller, M et al. “Poor clinical sensitivity of rapid antigen test for Influenza A pandemic (H1N1) 2009 virus”. Emerg Infect Dis. 2009; 15:1662–4.

  6. Agoritsas, K; Mack, K; Bonsu, BK; Goodman, D; Salamon, D; Marcon, MJ et al. “Evaluation of the Quidel QuickVue test for detection of Influenza A and B viruses in the pediatric emergency medicine setting by use of three specimen collection methods”. J Clin Microbiol. 2006; 44:2638–41.

  7. Grijalva, CG; Poehling, KA; Edwards, KM; Weinberg, GA; Staat, MA; Iwane, MK et al. “Accuracy and interpretation of rapid Influenza tests in children”. Pediatrics. 2007; 119:e6–11.

  8. Faix, DJ; Sherman, SS; Waterman, SH. “Rapid test sensitivity for novel swine-origin Influenza A (H1N1) virus in humans”. N Engl J Med. 2009; 361:728–9.

  9. González, CJ, Iglesias, CJ; Romero, AY; Chávez, CC; Gay; MJ; Rodolfo, RR. “Costo-efectividad en la detección de Influenza H1N1: Datos clínicos versus pruebas rápidas”. Rev Panam Salud Pública. 2011; 29(1):1-7.

  10. Uyeki, TM; Prasad, R; Vukotich, C et al. “Low sensitivity of rapid diagnostic test for Influenza”. Clin Infect Dis 2009; 48(9): e89-e92.

  11. Dennis, J; Faix, SS; Sherman, SH. “Rapid-Test Sensitivity for Novel Swine-Origin Influenza A (H1N1) Virus in Humans”. N Engl J Med. 2009; 361: 728–9.

  12. Lance, CJ; Heino, SI; Hribar, I; Del Piero; Deichmann, KA. “Effect of Rapid Influenza Testing on the Clinical Management of Paediatric Influenza”. http://www.medscape.com/viewarticle/703353. [consultado el 12 de marzo de 2012].

  13. “QuickVue Influenza A+B test. Información del producto”. p. 23-45 http://www.kabla.mx/index. php?option=com_content&view=article&id=105:quic kvue-Influenza-a--b&catid=42:enfermedades-infecciosas [consultado el 12 de marzo de 2012].

  14. Castro, CL; Llaca, DJ; Pérez; CF; Gómez, EI; Flores, AA. “Estudio comparativo entre una prueba rápida y RTPCR tiempo real en el diagnóstico de Influenza AH1N1 2009”. Salud Pública de México 2011; 53(4): 329-333.

  15. Atmar R, Baxter B, Dominguez E, Taber L. “Comparison of reverse transcription-PCR with Tissue culture and other rapid diagnostic assays for detection of type A Influenza virus”. J Clin Microbiol 1996: 2604-2606.




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