medigraphic.com
Organo Oficial de la Sociedad Mexicana de Urología

2012, Number 6

<< Back Next >>

Rev Mex Urol 2012; 72 (6)

Erectile dysfunction and cardiovascular disease: what do we know up to now?

Carrillo-Córdova LD, Carrillo-Esper R, Villena-López EL, Carrillo-Córdova JR, Carrillo-Córdova CA, Carrillo-Córdova DM

Language: Spanish
References: 29
Page: 286-292
PDF size: 135.91 Kb.


ABSTRACT

There is a 20% to 35% prevalence of erectile dysfunction (ED) in the general population and it can be 50% to 70% in patients with cardiovascular disease (CVD). ED association with CVD risk factors can be explained by penile vessel endothelial damage, given that these vessels play a crucial role in achieving and maintaining erection. The presence and severity of ED is correlated with the presence of CVD and is an early symptom of atherogenic disease. A large number of deaths and complications associated with CVD have been found in ED patients, therefore they should be directly and aggressively studied for CVD in order to receive early diagnosis and treatment.


REFERENCES

  1. NIH Consensus Conference. Impotence. NIH Consensus Development Panel on Impotence. JAMA 1993;270(1):83-90.

  2. Seftel AD, Sun P, Swindle R. The prevalence of hypertension, hyperlipidemia, diabetes mellitus and depression in men with erectile dysfunction. J Urol 2004;171(6 Pt 1):2341-2345.

  3. Feldman HA, Goldstein I, Hatzichristou D, et al. Impotence and its medical and psychological correlates: results of the Massachusetts Male Aging Study. J Urol 1994;151(1):54-61.

  4. Bortolotti A, Parazzini F, Colli E, et al. The epidemiology of erectile dysfunction and its risk factors. Int J Androl 1997;20(6):323-334.

  5. Montorsi F, Briganti A, Salonia A, et al. Erectile dysfunction prevalence, time of onset and association with risk factors in 300 consecutive patients with acute chest pain and angiographically documented coronary artery disease. Eur Urol 2003;44(3):360-364.

  6. Kloner R, Mullin S, Shook T, et al. Erectile dysfunction in the cardiac patient: how common and should we treat? J Urol 2003;170(2 Pt 2):S46-50.

  7. Korpelainenl JT, Kauhanen ML, Kemola H, et al. Sexual dysfunction in stroke patients. Acta Neurol Scand 1998;98(6):400-405.

  8. Durazzo M, Premoli A, Di Bisceglie C, et al. Male sexual disturbances in liver diseases: what do we know? J Endocrinol Invest 2010;33(7):501-505.

  9. Saigal CS, Wessells H, Pace J, et al. Predictors and prevalence of erectile dysfunction in a racially diverse population. Arch Intern Med 2006;166(2):207-212.

  10. Grover SA, Lowensteyn I, Kaouache M, et al. The prevalence of erectile dysfunction in the primary care setting: importance of risk factors for diabetes and vascular disease. Arch Intern Med 2006;166(2):213-219.

  11. Bacon CG, Hu FB, Giovannucci E, et al. Association and type and duration of diabetes with erectile dysfunction in a large cohort of men. Diabetes Care 2002;25(8):1458-1463.

  12. Rhoden EL, Ribeiro EP, Riedner CE, et al. Glycosylated hemoglobin levels and the severity of erectile function in diabetic men. BJU Int 2005;95(4):615-617.

  13. Welt FGP, Simon DI. Atherosclerosis and plaque rupture. Catheter Cardiovasc Interv 2001;53(1):56-63.

  14. Crisby M, Nordin-Fredrikson G, Shah PK, et al. Pravastatin treatment increases collagen content and decreases lipid content, inflammation, metalloproteinases, and cell death in human carotid plaques: implications for plaque stabilization. Circulation 2001;103(7):926-933.

  15. Vita JA, Treasure CB, Nabel EG, et al. Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease. Circulation 1990;81(2):491-497.

  16. Celermajer DS, Sorensen KE, Bull C, et al. Endothelium-dependent dilation in the systemic arteries of asymptomatic subjects relates to coronary risk factors and their interaction. J Am Coll Cardiol 1994;24(6):1468-1474.

  17. Azadzoi KM, Goldstein I. Erectile dysfunction due to atherosclerotic vascular disease: the development of an animal model. J Urol 1992;147(6):1675-1681.

  18. Bocchio M, Desideri G, Scarpelli P, et al. Endothelial cell activation in men with erectile dysfunction without cardiovascular risk factors and overt vascular damage. J Urol 2004;171(4):1601-1604.

  19. Kaiser DR, Billups K, Mason C, et al. Impaired brachial artery endothelium- dependent and independent vasodilation in men with erectile dysfunction and no other clinical cardiovascular disease. J Am Coll Cardiol 2004;43(2):179-184.

  20. Elesber AA, Solomon H, Lennon RJ, et al. Coronary endothelium dysfunction is associated with erectile dysfunction and elevated asymmetric dimethylarginine in patients with early atherosclerosis. Eur Heart J 2006;27(7):824-831.

  21. Vlachopoulos C, Rokkas K, Loakeimidis N, et al. Inflammation, metabolic syndrome, erectile dysfunction and coronary artery disease: common links. Eur Urol 2007;52(6):1590-1600.

  22. Thompson IM, Tamgen CM, Goodman PJ, et al. Erectile dysfunction and subsequent cardiovascular disease. JAMA 2005;294(23):2996- 3002.

  23. Gazzaruso C, Solerte SB, Pujia A, et al. Erectile dysfunction as a predictor of cardiovascular events and death in diabetic patients with angiographically proven asymptomatic coronary artery disease: a potential protective role for statins and 5-phosphodiesterase inhibitors. J Am Coll Cardiol 2008;51(21):2040-2044.

  24. Ma RC, So WY, Yang X, et al. Erectile dysfunction predicts coronary artery disease in type 2 diabetics. J Am Coll Cardiol 2008;51(21):2045- 2050.

  25. Bohm M, Baumhakel M, Teo K, et al. Erectile dysfunction predicts cardiovascular events in high-risk patients receiving telmisartan, ramipril, or both: the Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial/Telmisartan Randomized Assessment Study in ACE Intolerant Subjects with Cardiovascular Disease (ONTARGET/TRANSCEND) trials. Circulation 2010;121(12):1439-1446.

  26. Jackson G, Padley S. Erectile dysfunction and silent coronary artery disease: abnormal computed tomography coronary angiogram in the presence of normal exercise ECGs. Int J Clin Pract 2008;62(6):973-976.

  27. Min JK, Williams KA, Okwuosa TM, et al. Prediction of coronary heart disease by erectile dysfunction in men referred for nuclear stress testing. Arch Intern Med 2006;166(2):201-206.

  28. Montorsi P, Ravagnani PM, Galli S, et al. Association between erectile dysfunction and coronary artery disease. Role of coronary clinical presentation and extent of coronary vessels involvement: the COBRA trial. Eur Heart J 2006;27(22):2632-2639.

  29. Montorsi P, Ravagnani PM, Galli S, et al. The artery size hypothesis: a macrovascular link between erectile dysfunction and coronary artery disease. Am J Cardiol 2005;96(12B):19M-23M.




2020     |     www.medigraphic.com