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2011, Number 3

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Anales de Radiología México 2011; 10 (3)

Diagnóstico de la recurrencia del carcinoma colorrectal con PETCT 18F-FDG en pacientes con resección quirúrgica de la lesión primaria: correlación con hallazgos histopatológicos

Sánchez-Rodríguez V, Ochoa-Figueroa MA, Hernández-Briz MJ

Language: Spanish
References: 17
Page: 187-193
PDF size: 248.21 Kb.


ABSTRACT

Purpose. Evaluate the diagnostic efficacy of PET-CT 18FFDG in patients with high suspicion of recurrence of colorectal carcinoma.
Material and methods. A retrospective study of 61 patients with suspected relapse of colorectal carcinoma, at Hospital Insular de Las Palmas de Gran Canaria, who underwent a PETCT examination with 18F-FDG at Instituto PET Focuscan (Madrid) from May 2006 through December 2008. Three patients were excluded and 58 were included (33 men and 25 women, average age 63 years). Before the PET-CT examination all underwent surgical resection of the primary lesion. Seven patients underwent surgery only, 34 surgery and chemotherapy, and 15 surgery, radiotherapy, and chemotherapy. All underwent a hybrid PET/CT 18F-FDG study. Subsequently, relapse was confirmed by pathological anatomy in 31 cases (22 with recurrence and 9 without recurrence) and by clinical evolution in 25 cases (11 with recurrence and 14 without recurrence), all with a clinical follow-up period of more than 6 months.
Results. The global results of the PET-CT 18F-FDG study in patients with suspected relapse of colorectal carcinoma at our site were sensitivity, specificity, VPP, VPN, and overall study accuracy of 90, 83, 88, 86, and 88%, respectively.
Conclusion. PET-CT 18F-FDG is a valuable diagnostic tool in patients with signs of recurrence of colorectal carcinoma and should be added to diagnostic imaging resources when relapse is suspected, both due to presence of a rise in tumor markers or suggestive lesions in image tests and due to clinical signs, to rule out relapse. Patients with suspected local relapse in the postsurgical zone warrant special consideration, and acquisition of late images should be estimated with a proper morphologic and metabolic assessment of such localization.


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