González RM, Neri BL, Salgado CH, Orozco SSA

Language: Spanish
References: 65
Page: 84-92
PDF size: 169.95 Kb.

ABSTRACT

There is evidence that demonstrates that the changes in the inhibitory and excitatory amino acids can be involved in the susceptibility and induction of the seizures. Objective: evaluate in a short term the modifications in the tissular content of inhibitory and excitatory amino acid in the rat´s forebrain of 10 days of age, 30 min, 24 h and 20 days after hyperthermic seizures (HS). in the rat´s forebrain of 10 days of age, 30 min, 24 h and 20 days after hyperthermic seizures (HS). Material and methods: the HS was induced in rats of 10 days of age, when applying a moderate hot air current, approximately 50 cm from them; their brains were used to quantify the tissular content of inhibitory and excitatory amino acid by HPLC. Results: Regarding tissular content of amino acid, the CH30min group after HS showed a significant increase of all of them in the different evaluated structures. The CH24h group presented a significant increase of glutamate, and glutamine in the hippocampus, as well as aspartate and glutamate in amygdale. In addition, the brain stem showed a significant increase in many of the analyzed amino acid, while in the other evaluated structures was observed a significant decrease of the same amino acids. The CH20d group presented an increase in all amino acid in the striatum and cerebellum. Conclussion: The results of the present study do not support the hypothesis that HS in early stage induces long term changes similar to those observed in epilepsy model of temporal lobe in adult animals.

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