2009, Number 5
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Med Int Mex 2009; 25 (5)
Factores asociados con la mortalidad de ancianos hospitalizados por neumonía adquirida en la comunidad
Romero CÁJ
Language: Spanish
References: 21
Page: 344-351
PDF size: 326.32 Kb.
ABSTRACT
Background: Community-acquired pneumonia (CAP) is very common in the elderly and has high mortality and hospitalization rates.
Objective: To identify the mortality factors associated among hospitalized elderly with community-acquired pneumonia.
Patients and method: Case-control study Cases: 40 dead elder patients with community-acquired pneumonia, controls: 40 alive elderly with CAP, randomly selected. The information (demographical, clinical, radiographic and analytical) was obtained by a formulary from the clinical records. The association power of selected variables with the outcome was measured by odd ratio (OR) and 95% confidence interval. Multivariate analysis was performed by logistic regression in an SPSS program v. 10.0. Results were considered significant when p ‹ 0.05. A mortality predictive model was implemented using variables with significance.
Results: The factors associated with mortality by univariate analysis were polimorbility, polipharmacy, immobility, urinary incontinence, cognitive impairment (dementia / confusion), pulse ≥ 95 x min, arterial hypotension, respiratory rate ≥ 31, elevated serum creatinine and bilateral affectation in chest X ray. The clinical variables with higher association power in multivariate analysis were polimorbility and confusion. The presence of three or more geriatric syndromes (polimorbility, immobility, urinary incontinence, dementia and confusion) had high specificity and a high positive predictive value in association with mortality. From all of these, polimorbility and cognitive impairment had a 93,71 % specificity and a 90,68 % positive predictive value.
Conclusions: Polimorbility and cognitive impairment were associated with CAP mortality in hospitalized elderly.
REFERENCES
Rajagopalan S. Pulmonary infections. In: Beers MH ed. The Merck Manual of Geriatrics. 3th ed. URL disponible en http:// www.msd.com.mx . (Revisado: 14-03-07).
Cuevas GMC, Saera BM. Factores pronósticos en la neumonía comunitaria grave. Med Intensiva 2004;28(8):419-24.
Luna CM, Famiglietti A, Abai R, et al. Community-acquired pneumonia. Etiology, epidemiology and outcome at a teaching hospital in Argentina. Chest 2000;118:1344-54.
Fein AM. Pneumonia in the elderly: Overview of diagnostic and therapeutic approaches. Clin Infect Dis 1999;28:726-29.
Quintero Méndez Y. Mortalidad del adulto mayor en tres provincias cubanas (1990-99). Trabajo de terminación de la Especialidad en Medicina Interna. Cienfuegos, 2002. (Observaciones no publicadas).
Espinosa A, Quintero Y, Cutiño Y, y col. Mortalidad del adulto en tres provincias cubanas (1990-99). En: Heterogeneidad social en la Cuba actual. Centro de Estudios de Salud y Bienestar Humano. Universidad de La Habana, 2004;pp:163-93.
Farr BM. Prognosis and decisions in pneumonia. N Engl J Med 1997;336: 287-89.
Guía de Buena Práctica Clínica: Neumonía adquirida en la comunidad. URL disponible en http://www.gal.sld.cu. (Revisado en 16-03-07).
Guía de Buena Práctica Clínica: Neumonía en el anciano. URL disponible en http://www.gal.sld.cu. (Revisado en 16-03-07).
Corona LA, Fragoso MC, González I, y col. Valoración del índice de riesgo como instrumento para la estratificación del paciente con neumonía adquirida en la comunidad en el Departamento de Urgencias. MEDISUR 2005; 3(2): 97-111.
Meyer KC. Lung infections and aging. Ageing Res Rev 2004; 3(1): 55-68.
Gottlieb S. Inappropriate drug prescribing in the elderly people is common. BMJ 2004;329:367.
Marvie TJ, Wu L. Factors influencing in-hospital mortality in community-acquired pneumonia: a prospective study of patients not initially admitted to the UCI. Chest 2005;127:1260-70.
Mendoza H, Tiberio G, Aizpuru F, y col. Neumonía en el anciano. Factores relacionados con la mortalidad durante el episodio y tras el alta hospitalaria. Med Clin (Barc) 2004;123:332-6.
García Ordóñez MA. Neumonía en el anciano: un viejo desafío, nuevas perspectivas. Med Clin (Barc) 2006;127(6): 214-5.
García Ordóñez MA, Payato-González B. Hospitalización de las neumonías adquiridas en la comunidad. Arch Bronconeumol 2003;39: 241.
Lim WS, Macfarlane JT. Defining prognostic factors in the elderly with community-acquired pneumonia: a case controlled study of patients aged > 75 yrs. Eur Respir J 2001;17:200-5.
Barlow G, Nathwant D, Davey P. The CURB-65 pneumonia severity store outperforms generic sepsis and early warning scores in predicting mortality in community-acquired pneumonia. Thorax 2007;62: 253-9.
Capelastegui A, España PP, Quintana JM, et al. Validation of a predictive rule for the management of community-acquired pneumonia. Eur Respir J 2006;27:151-7.
Myint PK, Kamath AV, Vowler SL, et al. Severity assessment criteria recommended by the British Thoracic Society for community-acquired pneumonia (CAP) and older patients. Should SOAR (systolic blood pressure, oxygenation, age and respiratory rate) criteria be used in older people? A compilation study of two prospective cohorts. Age Ageing 2006;35(3): 286-91.
Man SY, Lee N, Ip M, et al. Prospective comparison of three predictive rules for assessing severity of community-acquired pneumonia in Hong Kong. Thorax 2007;62:348-53.