2003, Number 3
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Rev Inst Nal Enf Resp Mex 2003; 16 (3)
Do age and services influence clinical diagnosis quality of lower respiratory tract sepsis?
Reyes CA, Rosa PJN, Díez MCE, Morejón GAF, Bouza JY
Language: Spanish
References: 47
Page: 136-144
PDF size: 90.80 Kb.
ABSTRACT
Context: Clinical Surgical University Hospital “Gustavo Aldereguía Lima”. Cienfuegos. Clinical Surgical University Hospital “Camilo Cienfuegos”. Sancti Spíritus (Both hospitals are situated in two provinces of the center of the Cuban island).
Objective: To determine the diagnostic efficiency of lower respiratory tract infections in necropsies of deceased individuals.
Patients: The necropsies of 1556 deceased individuals were studied. Of these, 915 were from the Cienfuegos Hospital and 641 necropsies from the Sancti Spíritus Hospital. There were 661clinical diagnostics and 608 pathological diagnostics of lower respiratory tract sepsis.
Method: A retrospective, descriptive and correlational design was employed. We used the statistical packages: EPI INFO 6.04 CDC/OMS 2001, EPIDAT 2.0 Xunta de Galicia 1998, and the mean ratio was a= 0.05.
Measurements: The variables of age and service where the patients had died, were correlated with the measurements of diagnostic efficiency: crude concordance, Kappa index (K), sensibility (S), specificity (E), positive and negative predictive values (PPV and NPV).
Results and conclusions: For lower respiratory tract sepsis, concordance was moderate (k= 0.56) although it reached the substantial category in Sancti Spíritus Hospital. Both the sensitivity and the specificity surpassed 75%. The clinic pathological concordance of deceased patients less than 60 years old was high in both hospitals, although not statistically significant. The increase in diagnostic sensitivity of the elderly deceased patients due to respiratory sepsis (S=81.2%), and the decrease in specificity for the same group (71.8%) is emphasized in the Cienfuegos Hospital. Differences in NPV were found in both age groups of deceased patients from Sancti Spíritus (NPV=76.6% in the elderly and NPV=87.2% in the elderly and in the rest of deceased patients). In general, the age of 60 and more did not significantly reduce the clinical diagnostic quality of the disease. Diagnostic efficiency was reduced in the Cienfuegos IMCU fundamentally due to the differences between the Kappa index (k=0.46 vs k=0.58) and the PPV (PPV=51.7% vs PPV=80.7%). The clinic pathological discordance increased in the clinical wards of both institutions.
REFERENCES
Vilches AR. Mortalidad hospitalaria decenio 1989–98 (tesis en Medicina Interna). Cuba, Cienfuegos: Hospital Clínico Quirúrgico Docente ”Dr. Gustavo Aldereguía Lima”, 2000.
Díez y Martínez de la Cotera E. Mortalidad del adulto: Estudio de algunos factores relacionados con la atención médica. Provincia de Cienfuegos 1981-1982 (tesis en Medicina Interna). Cuba, Cienfuegos: Hospital Provincial Clínico Quirúrgico Docente “Dr. Gustavo Aldereguía Lima”,1986.
Manresa PF. Enfermedades del sistema respiratorio: Infecciones pulmonares no tuberculosas. Neumonías, bronquiectasias y abscesos pulmonares. En: Teixidor JR, Massó JG, editores. Medicina interna. Barcelona: Masson, 1997; t.1: 1128-1140.
Ena J. Neumonía extrahospitalaria. Enfer Infect Microbial Clin 1995;13:166-172.
Fine MH. Prognosis and outcome of patient with community acquired pneumonia a meta analysis. JAMA 1996; 275: 134-141.
Soler RM. Neumonía nosocomial en la Unidad de Cuidados Intensivos. Rev Cubana Med 1993;32:74-84.
Woodhead MA, Macfarlane JT, McCracken JS, Rose DH, Finch RG. Prospective study of etiology and outcome of pneumonia in the community. Lancet 1987;1:671-674.
Pérez PR, Gaxiola M, Salas J, Sansores R, Garrillo G, et al. Capacidad clínica y de laboratorio para predecir el grado de fibrosis y el diagnóstico en enfermedades pulmonares. Rev Invest Clin 1995;47:95-101.
Sánchez A, Zapata L, Corte G, Pérez N, Jiménez R. Características clínicas y correlación endoscópico-histológica en pacientes con colitis ulcerosa crónica inespecífica. Rev Gastroenterol Mex 1993;158: 210-213.
Bartlett JG, Breiman RF, Mandell LA. For the Infectious Disease Society of America. Community acquired pneumonia in adults: Guidelines for management. Clin Infect Dis 1998;26:811-838.
Fraser KL, Grossman RF. What new antibiotics to offer in the outpatient setting? Semin Respir Infect 1998;13:24-25.
Marrie TJ. Community acquired pneumonia: epidemiology, etiology, and treatment. Infect Dis Clin North Am 1998; 12:723-740.
Reimer LG, Carroll KC. Role of microbiology laboratory in diagnosis of lower respiratory tract infections. Clin Infect Dis 1998;26:742-748.
Reyes CA. Estudio de mortalidad y concordancia clínico patológico. Fallecidos con necropsia. HGAL 1996 (tesis en Medicina Interna). Cuba, Cienfuegos: Hospital Clínico Quirúrgico “Dr. Gustavo Aldereguía Lima”, 1998.
Riegelman RK, Hirsch RP. Cómo estudiar un estudio y probar una prueba; lectura crítica de la literatura médica. 2da ed. Publicación científica No. 531. Washington: Organización Panamericana de la Salud, 1992:110-111.
Goldman L, Sayson R, Robbins S, Cohn LH, Bettmann M, Weisberg M. The value of autopsy in three medical eras. N Engl J Med 1983; 308:1000-1005.
Lynn J, Cobbs E, Orestein J. Autopsy rates and diagnosis. JAMA 1998;199:2181-2185.
Sackett D, Rosenberg WM, Mvir Gray JA, Haynes RB, Richardson WS. Medicina basada en evidencia clínica: alcances y limitaciones. Integración de la experiencia clínica individual con la mejor evidencia externa. BMJ (edición latinoamericana) 1996;4:57-58.
Santos PN. Relación clínico microbiológica anatomopatológica en fallecidos con diagnóstico de sepsis respiratoria baja (tesis en Medicina Interna). Cuba, Cienfuegos: Hospital Provincial Clínico Quirúrgico Docente “Dr. Gustavo Aldereguía Lima”, 1994.
Tay AJ. Mortalidad por bronconeumonía en el anciano. Estudio clínico patológico de los fallecidos en el servicio de Medicina Interna (tesis en Medicina Interna). Cuba, Cienfuegos: Hospital Provincial Clínico Quirúrgico “Dr. Gustavo Aldereguía Lima”, 1990.
Díaz CMA. Morbimortalidad del paciente geriátrico hospitalizado. Estudio realizado durante un semestre en las salas 12A y 12B del servicio de Medicina Interna. Febrero-julio, 1985 (tesis en Medicina Interna). Cuba, Cienfuegos: Hospital Provincial Clínico Quirúrgico “Dr. Gustavo Aldereguía Lima”, 1987.
Feinstein AR. Clinical epidemiology. Philadelphia: Saunders, 1985.
Álvarez BJA. Estudio de la concordancia y la eficiencia del diagnóstico clínico de los egresados fallecidos en el año 1999 y comparando con el 1996 (tesis en Medicina Interna). Cuba; Cienfuegos: Hospital Universitario Clínico Quirúrgico “Dr. Gustavo Aldereguía Lima”, 2000.
González RYA. Correlación clínico patológica en medicina interna (análisis de 600 fallecidos). Año 1996 (tesis en Medicina Interna). Cuba, Sancti Spíritus: Hospital Clínico Quirúrgico Universitario. “Camilo Cienfuegos Gorriarán”, 1997.
Fantin B, Shubert JP, Unger P, Lecoeur H, Carbon C. Clinical evaluation of the management of community acquired pneumonia by general practitioners in France. Chest 2001;120:185-192.
Almirante GB, Pigrau SC, Capdevila MJA, Pahissa BA. Neumonía extrahospitalaria en el paciente no inmunodeprimido. En: Álvarez-Mon SM, editor. Enfermedades infecciosas. Madrid: IDEPSA, 1998:77-83.
Clemente M, Budino T, Seco G, Santiago M, Gutiérrez M, Romero P. Community acquired pneumonia in the elderly: Prognostic factors. Arch Bronconeumol 2002;38: 67-71.
Lim WS, Macfarlane JT. Defining prognostic factors in the elderly with community acquired pneumonia: a case controlled study of patients age >=or<=75 yrs. Eur Respir J 2001;17:200.
Dean NC, Silver MP, Bateman KA, James B, Hadlock CJ, Hale D. Decreased mortality after implementation of a treatment guideline for community acquired pneumonia. Am J Med 2001;110:451-457.
Fein AM, Niederman S. Severe pneumonia in the elderly. Clin Geriatr Med 1994; 110:121-143.
Burgueño MJ, García-Bastos JL, Gonzáles BJM. Las curvas ROC en la evaluación de las pruebas diagnósticas. Med Clin (Barc) 1995;104:661-670.
Crossley K, Johnson J, Mudge R, Crossley L. An evaluation of autopsy review as a technique for infection control: a procedure of questionable value. Infect Control 1983;4:29-30.
Hernández ML. Sepsis respiratoria baja. Análisis clínico microbiológico y patológico de los fallecidos. Mayo del 99- abril del 2000 (tesis en Medicina Interna). Cuba, Cienfuegos: Hospital Provincial Universitario “ Dr. Gustavo Aldereguía Lima”, 2001.
Conde FBD. Estudio clínico en las enfermedades pulmonares inflamatorias agudas. (Servicio de Medicina, 1ro. de enero de 1983 al 31 de mayo de 1985). (Tesis en Medicina Interna). Cuba, Sancti Spíritus: Hospital Provincial Docente Clínico Quirúrgico. Sancti Spíritus, 1985.
Torres GA. Morbimortalidad por enfermedades respiratorias y costos terapéuticos asociados en la sala 4F de Medicina Interna (tesis en Medicina Interna). Cuba, Sancti Spíritus: Hospital Provincial Clínico Quirúrgico “Camilo Cienfuegos”, 1999.
Ramírez FA. Morbimortalidad por enfermedades respiratorias y costos terapéuticos asociados en la sala 4G de medicina interna (tesis en Medicina Interna). Cuba, Sancti Spíritus: Hospital Provincial Clínico Quirúrgico Docente “Camilo Cienfuegos”, 1998.
Dupont H, Mentec H, Sallet JP, Bleichner G. Impact of appropriates of initial antibiotic therapy on the outcome of ventilator-associated pneumonia. Intensive Care Med 2001;27:355-362.
Vanhems P, Lepope A, Savey A, Jambou P, Fabry J. Nosocomial pulmonary infection by antimicrobial resistant bacteria of patients hospitalized in the intensive care units: Risk factors and survival. J Hosp Infect 2000;45:98-106.
Bercault N, Boulain T. Mortality rate attributable to ventilator associated nosocomial pneumonia in an adult intensive care unit: a prospective case-control study. Crit Care Med 2001;29:2392-2394.
Singh N, Rogers P, Atwood CW, Wegener MM, Yu VL. Short course empiric antibiotic therapy for patients with pulmonary infiltrates in the intensive care unit. A proposed solution for indiscriminate antibiotic prescription. Am J Respir Crit Care Med 2000;162(2 Pt 1):505-511.
Abascal CM, González RR, La Rosa DA, Ulloa QF. Repercusión de la bronconeumonía en la mortalidad hospitalaria. Rev Cubana Med Militar 2001;30:99-105.
Herer B, Fuhrman C, Demontrond D, Gazevic Z, Housset B, Chouaid C. Diagnosis of nosocomial pneumonia in medical ward: Repeatability of the protected specimen brush. Eur Respir J 2001;18:157-163.
Leal NSR, Márquez VJA, García CA, Camacho LP, Rincón FMD, Ordoñez FA, et al. Nosocomial pneumonia in patients undergoing heart surgery. Crit Care Med 2000; 28:935-942.
Ibrahim EH, Ward S, Sherman G, Kollef MH. A comparative analysis of patients with early onset v/s late onset nosocomial pneumonia in the UCI setting. Chest 2000;117:1434-1442.
Coalson JJ. The pathology of nosocomial pneumonia. Clin Chest Med 1995;16:13-28.
Medrano GF, Solis G del Pozo J, Gomariz GS, Solera SJ. Community acquires pneumonia requiring hospital admission. A comparison of the clinical management resource use and prognosis by different medical specialities. Rev Clin Esp 2001; 201:65.
Takano Y, Sakamoto O, Suga M, Ando M. Prognostic factors of nosocomial pneumonia in general wards: a prospective multivariate analysis in Japan. Respir Med 2002;96:18-23.