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2008, Number 3

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Rev Med Hosp Gen Mex 2008; 71 (3)

Frequency of paroxysmal nocturnal hemoglobinuria in Mexican patients with aplastic anemia treated with androgens

Ferrer-Argote VE, Mendoza-García E, García-García JJ, Collazo-Jaloma J, León-González G

Language: Spanish
References: 15
Page: 137-140
PDF size: 105.64 Kb.


ABSTRACT

Background: The association of paroxysmal nocturnal hemoglobinuria (PNH) and aplastic anemia (AA) has been considered a complication of immunosuppressive therapy for the AA and the reported frequency among patients treated with androgens is ‹10%. Objectives: To determine the frequency of PNH among a group of Mexican patients with AA treated with androgens. Materials and Methods: We carried out a retrospective study of 50 cases with AA who had a Ham’s acidified serum test to detect PNH. Results: We found 14/50 (28%) cases of AA/PNH, nine males and five females with an age range of 13-70 years. Ham´s test was positive at the time of the diagnosis of AA in four. For the rest it became positive six to 180 months later. Nine of them received only androgens and low doses of prednisone for the AA and only one received cyclosporine. Conclusions: These results show an almost threefold increase in the expected frequency of AA/PNH for AA patients treated with androgens and do not support the hypothesis of PNH being a complication of the immunosuppressive therapy for AA since almost one third of the patients had PNH from the beginning and of the other ten, nine had not received immunosuppressors.


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