2008, Number 5
<< Back Next >>
Cir Cir 2008; 76 (5)
Prognostic factors of nonunion in patients with traumatic fractures and secondary bone infection treated and stabilized by the method of Colchero
Gómez-Pineda AA, Cicero-Álvarez AA, Escobedo-Troncoso VM, Olivares-Peréz C, León-Hernández SR, Martínez-Canseco C
Language: Spanish
References: 16
Page: 381-385
PDF size: 50.79 Kb.
ABSTRACT
Objective: We undertook this study to identify the prognostic factors of nonunion in traumatic fractures treated and stabilized by the method of Colchero.
Methods: Included in the study were 140 patients with bone infection, 31 with traumatic fractures treated and stabilized with the method of Colchero, of which 26 healed and 5 evolved to nonunion. Factors analyzed were age; sex; occupation; smoking; alcoholism; presence of degenerative diseases; cause, type and pattern of the fracture; bone affected; type of implant; hemoglobin; neutrophils; lymphocytes; proteins; albumin; and erythrocyte sedimentation rate.
Results: Significant differences were found in complex or comminuted fractures with a risk of 11.5 times higher of resulting in nonunion (
p = 0.038). Average of neutrophils in nonunion was 1.8 ± 0.69 vs. 5.5 ± 1.7 in consolidation (
p = 0.008); average of albumin was 4.2 ± 0.31 in nonunion vs. 3.8 ± 0.36 in nonunion consolidation (
p = 0.022).
Conclusions: We should consider comminuted fracture as a risk for nonunion, in relation to nutritional and immunological factors. Patients who consolidated presented neutrophils in the normal range as a response to the bacterial infection with a decrease in albumin levels because of the bone repair process. In nonunion there was neutropenia with normal albumin levels, which most likely suggests an inadequate response to the infection. Albumin remains within normal ranges because there is no bone repair process.
REFERENCES
Zink BJ, Weber JE. Bone and joint infections. In: Rosen P, Barkin R, eds. Emergency Medicine: Concepts and Clinical Practice. 5th ed. St Louis: CV Mosby;2001. pp. 1725-1749.
Aro H, Eerola E, Aho AJ, Niinikoski J. Tissue oxygen tension in externally stabilized tibial fractures in rabbits during normal healing and infection. J Surg Res 1984;37:202-207.
Cordero J, Munuera L. Influence of bacterial strains on bone infection. J Orthop Res 1996;14:663-667.
Ranal MR. Nuevos paradigmas en la regulación de metabolismo óseo. Rev Invest Clin 2001;53:362-369.
Safdar NK, Mathias PG, Joseph M. Tissue engineering in orthopedic surgery. Bone growth factors. Orthop Clin North Am 2000;31:3.
Nair SP. Bacterially induced bone destruction: mechanisms and misconceptions. Infect Immun 1996;64:2371-2380.
Nair SP. Advances in our understanding of the bone and joint pathology caused by Staphylococcus aureus infection. Rheumatology 2000;39:821-834.
Kong YY, Feige U, Sarosi I, Bolon B, Tafuri A, Morony S, et al. Activated T cells regulate bone loss joint destruction in adjuvant arthritis through osteoprogeterin ligand. Nature 1999;402:304-309.
Takayanagi H, Ogasawara K, Hida S, Chiba T, Murata S, Sato K, et al. Tcell- mediated regulation of osteoclastogenesis by signaling cross-talk between RANKL and IFN-γ. Nature 2000;408:600-605.
Colchero Rozas F. Tratamiento integral del paciente con infección ósea. México: Trillas;1990. pp. 39-61.
Marsh DR, Shah S, Elliot J, Kurdy N. The Ilizarov method in nonunion, malunion and infection of fractures. Br Soc Bone Joint Surg 1997;79-B(2):273-279.
Simpson AH. Histological assessment of the presence or absence of infection in fracture non-union. Injury 2002;33:151-155.
Sela J, Gross UM, Kohavi D, Shani J, Boyan BD, Schwartz Z. Woven bone formation around implants and the effect of bacterial infection. J Long Term Eff Med Implants 1999;9:47-65.
Richards RR, Mahoney JL, Minas T. Influence of soft tissue coverage on the healing of cortical defects in canine diaphyseal bone. Ann Plast Surg 1986;16:296-304.
Pacheco R, Bradbury M, Kasis A, Saleh M. Review management of nonunion in trauma. Trauma 2004;6:225-247.
Looker AC. Clinical use of biochemical markers of bone remodeling: current status and future directions. Osteoporos Int 2000;11:467-480.