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2007, Number 4

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Bioquimia 2007; 32 (4)

Associations between insulin resistance index, cortisol levels and anthropometric variables in mexican children

Méndez-Castillo JE, Flores-Sánchez J, Noyola DE, Cruz-Mendoza E, Calderón-Hernández J, Aradillas-García C

Language: Spanish
References: 49
Page: 126-133
PDF size: 130.75 Kb.


ABSTRACT

Introduction: Diabetes mellitus and cardiovascular disease represent some of the most important public health problems in the world. In Mexico, they are the foremost mortality causes in general population. In addition, it is widely documented that obesity is one of the main factor associated with diabetes mellitus and cardiovascular disease, and cases of obesity among children are increasing. Dysfunction of the hypophysis-hypothalamic-adrenal axis, increased blood glucose levels and altered patterns of insulin secretion are all associated with obesity. Objective: To evaluate the presence of insulin resistance among Mexican children and its possible association with serum cortisol and anthropometric variables. Methods: In children aged between 6 and 13 years of both sexes, levels of insulin, glucose and cortisol (morning and evening) were determined. Insulin resistance was calculated by means of the HOMA procedure. Results: The number of children included in the study was 149 (73 boys and 76 girls). Overweight or obesity were present in 42% and 35% of the women and men, respectively. Serum insulin levels higher than 15 µUI/mL were more frequent among women (34.2% in girl’s vs 17.8% in boys, p = 0.037). The presence of insulin resistance was significantly associated with gender (p = 0.005), IMC (p ‹ 0.001), age (p = 0.02) and morning cortisol levels (p ‹ 0.01). Conclusions: Obesity and insulin resistance are very frequent among Mexican children, and these disorders affect more women than men. The cortisol levels (morning and evening) were associated with height (p ‹ 0.01 y p = 0.005) respectively. In women no significant associations between anthropometric measures and cortisol levels were observed. However, the insulin resistance was associated with morning cortisol, body mass index and age.


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