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Órgano Oficial de la Asociación Mexicana de Infectología Pediátrica y la SLIPE.

2006, Number 77

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Rev Enfer Infec Pediatr 2006; 19.20 (77)

Etiología of sudden hepatitis in children

Montijo-Barrios E, García-López R, Cervantes-Bustamante R, Ramírez-Mayans J, Mata-Rivera N, Zárate-Mondragón F, García-Campos M

Language: Spanish
References: 21
Page: 8-10
PDF size: 44.01 Kb.


ABSTRACT

Background. Fulminant hepatitis is a liver acute failure, with or without encephalopathy and retarded coagulation secondary to systemic effects from toxins. The most common etiology of hepatitis in children is infection with virus A (in endemic countries) and drugs as acetaminophen.
Objective. To describe the etiology of patients with liver failure in Mexican children from Instituto Nacional de Pediatría (INP).
Methods. An observational, descriptive and retrospective study was performed. Patients with liver failure criteria, attended at INP in Mexico City from January 1998 to May 2004 were included. Clinical (age, gender, medication, toxic substances), biochemical (liver function test), culture blood, IgM for HAV, HBV, HCV, CMV, parvovirus B19, EBV and antibodies for SMA, ANA, LKM 1 and metabolic test were reviewed.
Results. 30 patients were included. The mean age was 4.4 years (2 months – 16 years). 17 were female and 13 were male. All patients had encephalopathy and protrombin time lower than 50%. Most common ethiologic agents were: IgM HAV in 12 patients (40%), 4 (13.3%) had autoimmune hepatitis, bacteria were implicated in 3 cases (10%). 2 (6.6%) were associated with inborn metabolism disorders, in 5 (16.6%) other viruses were found and finally acetaminophen ingestion was in 1 (3.3%); 4 (13.3%) were idiopathic.
Conclusion. The most common etiology in Mexican children with fulminant hepatitis was VHA infection; nevertheless, autoimmune hepatitis and metabolic disorders should be considered.


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