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2007, Number 2

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Rev Mex Anest 2007; 30 (2)

Usefulness of the pharmacokinetics and pharmacodynamics interactions of analgesic drugs

Medina-López JR, Domínguez-Ramírez AM, López-Muñoz FJ

Language: Spanish
References: 44
Page: 114-121
PDF size: 91.93 Kb.


ABSTRACT

This literature review addresses the pharmacokinetics/pharmacodynamics interactions of non-steroidal anti-inflammatory drugs in preclinical studies. At the introduction are presented basic definitions, then the experimental models to evaluate pain, particularly an induced-pain model of rats limb dysfunction, finally the interactions are addressed. Pharmacokinetics studies the temporal course of drug inside the body, and pharmacodynamics studies the effects that a drug causes. Modeling pharmacokinetic/pharmacodynamics interactions turn out suitable combinations of analgesic drugs that include the type and proportion [of drugs] for appropriate pain management. These studies allow to associate plasma and therapeutic data through a mathematical predictive model. In preclinical studies carried out with animal models the addition of adjuvant compounds such as caffeine to some non-steroidal anti-inflammatory drugs, has proven to boost its therapeutic effect; thus reducing the administered dose of the original compounds and its adverse effects. This information is relevant for health professionals and may help to improve patients’ quality of life.


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