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2022, Number 3

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Rev Cubana Med Trop 2022; 74 (3)

Oxidative distress and its molecular implication for some infectious diseases: A review

Gil VL, Gravier HR, Acosta SMA, Pérez ALJ, Garrido G

Language: Spanish
References: 78
Page:
PDF size: 619.10 Kb.


ABSTRACT

Introduction: Reactive oxygen/nitrogen/sulfur species (RONSS) are continuously generated in the physiology of organisms. As part of the immune cell response to pathogens, they may increase and lead to oxidative stress, cytotoxicity and organ damage. Recognizing the molecular implications of RONSS is still a developing field of research.
Objective: To describe the molecular aspects related to oxidative metabolism and some pathogens (viruses, parasites, bacteria and fungi) in relation to infections.
Methods: Based on the search criteria, 520 documents were identified in LILACS, Science Direct, SciELO, EMBASE, PubMed and Infomed databases, using the search engines Google and Google Scholar. Of these, 78 documents published from 1980 to 2021 in Spanish or English and organized into seven subtopics were analyzed.
Information, analysis and synthesis: Infectious agents and the host interact to produce RONSS that can overcome antioxidant defense systems influencing on oxidative stress. Biological processes associated with the redox state are related to the transcription factors Nrf2 and NF-κB. Both generate a cellular response between susceptibility and resistance to infectious agents, thus they can initiate or accelerate pathophysiological processes in the organism. In general, the redox response in infectious pathophysiology is interconnected with metabolic reprogramming, antimicrobial and inflammatory responses, and cellular or tissue dysfunction.
Conclusions: Molecular redox events may be involved in various infectious diseases, where different associated responses or disorders mediate.


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