2022, Number 3
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Rev Med UAS 2022; 12 (3)
The waist circumference is the solely anthropometric variable that HOMA-IR predicts: a study of a cohort of young women
Maldonado-Cervantes MI, Castillo-Hernández JR, Martel-Gallegos MG, Maldonado-Cervantes E, Patiño-Marín N, García-Rangel M, Torres-Rodríguez L
Language: Spanish
References: 20
Page: 175-183
PDF size: 550.90 Kb.
ABSTRACT
Objective. To evaluate the capacity of anthropometric measures to predict IR in a cohort of young women without diabetes.
Material and methods. Descriptive, correlational and quantitative cross-sectional study. 60 university women aged 17 to 20 years,
without diabetes or systemic inflammation were studied, all participants signed an informed consent. Nine anthropometric measurements
were obtained such as: body mass index (BMI), waist circumference (WC) and% body fat (% BC). Fasting plasma glucose and
insulin concentrations were determined to calculate HOMA-IR.
Results.The successive step linear regression model, retained only
WC as a HOMA-IR predictor. Surprisingly, it did not retain BMI or % BF. The model had a greater predictive force among overweight
and obese women than those with normal weight. Using ROC (receiver operating characteristic curve) we showed that, 81.5 cm of
WC, had the highest sensitivity and specificity, 80.0% and 82.2% respectively.
Conclusions. WC is a powerful and unique anthropometric
measure to predict IR, especially in overweight and obesity groups. We propose that WC be included by primary care physicians
as an IR scrutiny tool.
REFERENCES
Chooi YC, Ding C, Magkos F. The epidemiologyof obesity. Metabolism 2019; 92:6-10.
Abdullah A, Peeters A, Courten M, StoelwinderJ. The magnitude of association betweenoverweight and obesity and the risk of diabetes:a meta-analysis of prospective cohortstudies. Diabetes Res Clin Pract 2010;89(3): 309-19.
Bogardus C, Lillioja S, Mott DM, HollenbeckC, Reaven GM. Relationship between degreeof obesity and in vivo insulin action inman. Am J Physiol 1985; 248: E286-E291.
Kim JK. Hyperinsulinemic–euglycemicclamp to assess insulin sensitivity in vivo.Methods Mol Biol 2009; 560: 221-238.
Matthews DR, Hosker JP, Rudenski AS,Naylor BA, Treacher DF, Turner RC. Homeostasismodel assessment: insulin resistanceand beta-cell function from fastingplasma glucose and insulin concentrations inman. Diabetologia 1985; 28(7):412-9.
Suárez GS, Díaz GL, Alvarez CA, López FV,Arias GMT, Prieto DM. Use of anthropometricmeasures to predict insulin resistance.Endocrinol Nutr 2008; 55(2):69-77.
Gómez GA, Nieto AE, Gómez AC, FigueroaNB, Álvarez AC. Parámetros antropométricoscomo predictores de resistencia a la insulinaen adultos con sobrepeso y obesidad.At Primaria 2010; 42(7):364–371.
Michaelsen VL, Braaten T, Kvaløy K, MelhusM, Broderstad AR. Relationships betweenmetabolic markers and obesity measures intwo populations that differ in stature—TheSAMINOR Study. Obes Sci Pract 2020; 6(3):324-339.
Faulkner JA. Physiology of swimming and diving.Res Q 1966; 37(1):41-54.
Fernández RJM, Vayreda M, CasamitjanaR, Saez M, Ricart W. Body mass index (BMI)and percent fat mass. A BMI > 27.5 kg/m2could be indicative of obesity in the Spanishpopulation. Med Clin (Barc) 2001; 117: 681-684.
Wedin WK, Diaz GL, Convit AJ. Prediction ofinsulin resistance with anthropometricmeasures: lessons from a large adolescentpopulation. Diabetes Metab Syndr Obes:Targets Therapy 2012; 5: 219–225.
Ferrannini E, Vichi S, Beck NH, Laakso M,Laakso P, Smith G and European Group forthe Study of Insulin Resistance. Insulin Actionand Age: European Group for the Studyof Insulin Resistance (EGIR). Diabetes1996; 45 (7): 947 - 953.
Srinivasan SR, Myersy L, Berenson GS.Changes in metabolic syndrome variablessince childhood in prehypertensive and hypertensivesubjects: The Bogalusa HeartStudy. Hypertension 2006; 48:33-9.
Reinehr T, Andler W. Changes in the atherogenicrisk factor profile according to degreeof weight loss. Arch Dis Child 2004; 89:419– 422.
Keskin M, Kurtoglu S, Kendirci M, AtabekME, Yazici C. Homeostasis model assessmentis more reliable than the fasting glucose/insulin ratio and quantitative insulinsensitivity check index for assessing insulinresistance among obese children and adolescents.Pediatrics 2005; 115(4): e500-3.
Vasques AC, Rosado LE, Galfenas R, GelonezeB. Critical analysis on the use of the homeostasismodel assessment (HOMA) indexesin the evaluation of the insulin resistanceand the pancreatic beta cells functional capacity.Arq Bras Endocrinol Metabol 2008;52: 32-9.
Silva de Morais PR, Lima SAL, de SouzaVJT, Nogueira NM, Mendonca KL, Rolim-Povoa TI et al. Correlation of Insulin Resistancewith Anthropometric Measures andBlood Pressure in Adolescents. Arq BrasCardiol 2016;106(4):319-326.
Ceballos PJC, Solís MRA, Quevedo CA, LópezMJJD, Moreno CML. Resistencia a la insulinay su relación con alteraciones bioquímicasy antropométricas en adolescentescon prediabetes. Rev Biomed 2020; 31(1)22-27.
Niţescu M, Streinu CA, Tusaliu M, Pitigoi D,Otelea M. Correlation between the waist circumference,diastolic blood pressure and insulinresistance in non-obese young adults.Acta Endocrinol (Buc) 2016; XII (4) 493-499.
Lena VG, Adams HB, Peshock R, Willet D,Shah B, Grundy S. Influence of body fat contentand distribution on variation in metabolicrisk. J Clin Endocrinol Metab 2006; 91(11):4459–4466.