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Anales de Otorrinolaringología Mexicana

2021, Number 4

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Otorrinolaringología 2021; 66 (4)

Comparison between resistance patterns and virulence factors in Staphylococcus aureus isolates from chronic rhinosinusitis with nasal polyposis patients and healthy subjects

Hernaiz-Leonardo JC, Schobert-Capetillo IH, Jiménez-Chobillon MA, Franco-Cendejas R

Language: Spanish
References: 29
Page: 296-308
PDF size: 242.28 Kb.


ABSTRACT

Objective: To compare the prevalence of nasal colonization, antibiotic susceptibility patterns, and virulence factors of Staphylococcus aureus isolated from chronic rhinosinusitis with nasal polyposis patients and healthy subjects.
Materials and Methods: A cross-sectional study was done from June 2018 to May 2019 in which S. aureus strains were isolated from the middle meatus of chronic rhinosinusitis with nasal polyposis patients and healthy subjects to determine antibiotic susceptibility patterns, Panton-Valentine leukocidin expression (PVL), and biofilm production in two reference centers.
Results: Nasal colonization prevalence was similar for both groups (12/54 chronic rhinosinusitis with nasal polyposis patients vs 8/40 healthy subjects, p = 0.52). No oxacillin resistant strains were isolated. Macrolide resistance was high (one patient with chronic rhinosinusitis with nasosinusal poliposis vs 5 healthy subjects, p = 0.2) as well as induced clindamycin resistance (20, n = 1 chronic rhinosinusitis with nasal polyposis patients vs 50%, n = 4 healthy subjects). None of the strains expressed PVL. Biofilm production was slightly higher in chronic rhinosinusitis with nasal polyposis patients, without reaching statistical significance.
Conclusions: S. aureus nasal colonization was similar for both groups. Macrolide and induced clindamycin resistance were high overall, which could lead to therapeutic failure if not properly identified.


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