Influenza tetravalent vaccines in national immunization programs for Latin-American countries

Alejandro E Macías Hernández; Fortino Solórzano Santos; Hugo M Aguilar Velasco; María L Ávila Agüero; Fernando Bazzino Rubio; Nancy C Junqueira Bellei; Pablo E Bonvehí; José Brea del Castillo; Héctor Castro Leguizamón; Carla M Allan Santos Domingues; DL García García María; Darío Londoño Trujillo; Pío López Lópe; Samuel Ponce de León Rosales; Patricia G Cervantes Powell; AN Suárez Ognio Luis; Guillermo M Ruiz-Palacios y Santos

2020, Number 3

Enf Infec Microbiol 2020; 40 (3)

Influenza tetravalent vaccines in national immunization programs for Latin-American countries

Macías HAE, Solórzano SF, Aguilar VHM, Ávila AML, Bazzino RF, Junqueira BNC, Bonvehí PE, Brea CJ, Castro LH, Allan SDCM, García GMDL, Londoño TD, López LP, Ponce de LRS, Cervantes PPG, Suárez OLAN, Ruiz-Palacios y Santos GM

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ABSTRACT

Since 2012-2013 influenza season, World Health Organization (WHO) recommends the formulation of tetravalent vaccines. Globally, many countries already use tetravalent vaccines in their national immunization programs, while in Latin America only a small number. Two Influenza b lineages co-circulate, their epidemiological behavior is unpredictable. On average they represent 22.6% of influenza cases and more than 50% in predominant seasons. The lack of concordance between recommended and circulating strains was 25 and 32% in the 2010-2017 and 2000-2013 seasons, respectively.
There are no clinical differences between influenza A and B. It occurs more frequently from five to 19 years of age. Influenza b has a higher proportion of attributable deaths than influenza a (1.1 vs. 0.4%), OR 2.65 (95% CI 1.18-5.94). A greater number of hospitalizations when the strains mismatch (46.3 vs. 28.5%; p ‹.0001). Different evaluations have demonstrated its cost effectiveness. The compilation of this information supports the use of quadrivalent vaccines in Latin American countries.

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