2018, Número 4
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Rev Hematol Mex 2018; 19 (4)
Linfomas no Hodgkin de estirpe B
Pérez-Zúñiga JM, Aguilar-Andrade C, Álvarez-Vera JL, Augusto-Pacheco M, Báez-Islas PE, Bates-Martín RA, Cervantes-Sánchez I, Espitia-Ríos ME, Estrada-Domínguez P, Jiménez-Alvarado R, Fermín-Caminero DJ, García-Camacho AS, Gómez-Rosas P, Grimaldo-Gómez FA, Guzmán-Mera P, Herrera-Olivares W, Martínez-Ramírez MA, Medina-Meza C, Mena-Zepeda V, Montoya-Jiménez L, Morales-Adrián JJ, Morales-Hernández AE, Mujica-Martínez A, Palma-Moreno OG, Reyes-Brena G, Reynoso-Pérez AC, Salazar-Ramírez Ó, Hernández-Ruiz E, Paredes-Lozano EP, Alvarado-Ibarra M
Idioma: Español
Referencias bibliográficas: 67
Paginas: 189-214
Archivo PDF: 567.44 Kb.
RESUMEN
El conocimiento de la ontogenia de los linfomas no Hodgkin ha permitido precisar y
separar los grupos específicos de linfoma no Hodgkin en cuanto a estirpe, localización,
características clínicas, genéticas y moleculares, entre otras. Sin duda, la aproximación
a la estirpe ha contribuido a mejorar las tasas de respuesta y la supervivencia, discriminando
variedades histológicas específicas, que además norman la conducta terapéutica
basada en su evolución natural, definiendo así diferentes modalidades de tratamiento
con resultados que buscan diversos objetivos, entre los más conocidos destacan la
supervivencia libre de enfermedad, tiempo libre a nuevo tratamiento o incremento
en la supervivencia global. Es indispensable utilizar diferentes herramientas, desde la
historia natural, sitios de manifestación, características histológicas, marcadores de
inmunohistoquímica, protocolos de diagnóstico con estos marcadores que favorezcan
la reproducibilidad y aproximación diagnóstica de mayor precisión. Asimismo,
el discernimiento de los diferentes subgrupos más frecuentes de linfomas no Hodgkin
estirpe B favorece la optimización de los resultados al diagnosticar y tratar con una
mayor precisión. En este documento se tratan los linfomas no Hodgkin de estirpe B
que consideramos más frecuentes en nuestro grupo, entre los que se encuentran los
linfomas difusos de células grandes, foliculares, de linfocitos pequeños, zona marginal,
manto, MALT y tipo Burkitt. Finalmente diversas variedades pueden manifestarse de
forma primaria en distintas localizaciones, destacan las gástricas y del sistema nervioso
central que obligan a establecer tratamientos precisos en estos sitios de manifestación
del linfoma no Hodgkin.
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