2018, Número 4
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Rev Hematol Mex 2018; 19 (4)
Complicaciones infecciosas posteriores al trasplante de progenitores hematopoyéticos
Colunga-Pedraza PR, Colunga-Pedraza JE, Bugarin-Estrada E, Yáñez-Reyes JM, Gutiérrez-Aguirre CH
Idioma: Español
Referencias bibliográficas: 90
Paginas: 215-230
Archivo PDF: 454.37 Kb.
RESUMEN
El trasplante de células progenitoras hematopoyéticas (TCPH) es una opción terapéutica
fundamental para pacientes con enfermedades hematológicas. Las infecciones
constituyen causa importante de morbilidad en el paciente trasplantado, con tasas de
mortalidad que varían desde 8% en trasplante autólogo hasta 20% en alogénico. Múltiples
factores contribuyen al riesgo elevado de infecciones en el paciente trasplantado,
como la edad, las comorbilidades, el régimen de acondicionamiento, la compatibilidad
HLA, la administración de agentes inmunosupresores y el tipo de trasplante. Debido a
la reconstitución hematopoyética e inmunológica que tiene lugar durante el trasplante,
los pacientes estarán más propensos a adquirir determinados agentes infecciosos, entre
bacterias, virus y organismos micóticos. Por ello, es de gran relevancia para el hematólogo
conocer las causas infecciosas más frecuentes en este escenario para efectuar
el abordaje preventivo, diagnóstico y terapéutico apropiado.
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