2017, Número 4
<< Anterior Siguiente >>
Rev Educ Bioquimica 2017; 36 (4)
La enzima glucógeno sintasa cinasa 3 regula la actividad de los factores de transcripción NF-kB y creb durante la respuesta inflamatoria causada por Staphylococcus aureus
Huante MA, Silva GO, Rico MR, Maldonado PMC, Baizabal AVM
Idioma: Español
Referencias bibliográficas: 26
Paginas: 111-117
Archivo PDF: 597.73 Kb.
RESUMEN
La enzima glucógeno sintasa cinasa 3 (GSK3) es una proteína cinasa de Ser/Thr,
que regula la expresión de citocinas durante la respuesta inflamatoria. GSK3 modula
la actividad del factor nuclear kB (NF-kB) y de la proteína de unión al elemento de
respuesta de AMPc (CREB). En esta revisión se presenta uno de los mecanismos
reguladores de la actividad de GSK3 y su efecto en las infecciones por
Staphylococcus
aureus.
REFERENCIAS (EN ESTE ARTÍCULO)
Gomperts BD, Kramer IM, Tatham PER (2003) Signal Transduction. Academic Press. Elsevier Science, Orlando, FL, USA.
Medzhitov R, Preston-Hurlburt P, Janeway CA (1997) A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388: 394–397.
Yang RB (1998) Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling. Nature 395: 284–288.
Dinarello CA (2000) Proinflammatory cytokines. Chest 118: 503–508.
O’Neill LA, Dinarello CA (2000) The IL-1 receptor/Toll-like receptor superfamily: crucial receptors for inflammation and host defense. Immunol Today 21: 206–209.
Jope RS, Johnson G (2004) The glamour and gloom of glycogen synthase kinase-3. Trends Biochem Sci 29: 95-102.
Martin M, Rehani K, Jope RS, Michalek SM (2005) Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3. Nat Immunol 6: 777-784.
Lawrence T, Fong C (2010) The resolution of inflammation: anti-inflammatory roles for NFkappaB. Int J Biochem Cell Biol 42: 519–523.
Steinke JW, Borish L (2006) Cytokines and chemokines. J Allergy Clin Immunol 117: S441–S445.
Lawrence T, Gilroy DW (2007) Chronic inflammation: a failure of resolution? Int J Exp Pathol 88: 85–94.
Commins SP, Borish L, Steinke JW (2010) Immunologic messenger molecules: cytokines, interferons, and chemokines. J Allergy Clin Immunol 125: 53–S72.
Embi N, Rylatt DB, Cohen P (1980) Glycogen synthase kinase-3 from rabbit skeletal muscle. Separation from cyclic-AMP-dependent protein kinase and phosphorylase kinase. Eur J Biochem 107: 519–527.
Cortés-Vieyra R, Bravo-Patiño A, Valdez- Alarcón JJ, Cajero-Juárez M, Finlay BB, Baizabal-Aguirre VM (2012) Role of glycogen synthase kinase-3 beta in the inflammatory response caused by bacterial pathogens. J Inflamm (Lond) 9: 23.
Fresno-Vara JA, Casado E, de Castro J, Cejas P, Belda-Iniesta C, González-Barón M (2004) PI3K/AKT signaling pathway and cancer. Cancer Treat Rev 30: 193-204.
Staal SP (1987) Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma. Proc Natl Acad Sci USA 84: 5034–5037.
Alessi DR, Andjelkovic M, Caudwell B, Cron P, Morrice N, Cohen P, Hemmings BA (1996) Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J 15: 6541–6551.
Ruse M, Knaus UG (2006) New players in TLRmediated innate immunity. Immunol Res 34: 33-48.
Beurel E, Michalek SM, Jope RS (2009) Innate and adaptive immune responses regulated by glycogen synthase kinase-3 (GSK3).Trends Immunol 31: 24-31.
Chan MM, Cheung BK, Li JC, Chan LL, Lau AS (2009) A role for glycogen synthase kinase-3 in antagonizing mycobacterial immune evasion by negatively regulating IL-10 induction. J Leukoc Biol 86: 283-291.
Hirschfeld M, Weis JJ, Toshchakov V, Salkowski CA, Cody MJ, Ward DC, Quresshi N, Michalek SM, Vogel SN (2001) Signaling by Toll-like receptor 2 and 4 agonists results in differential gene expression in murine macrophages. Infect Immun 69: 1477–1482.
Pulendran B, Kumar P, Cutler CW, Mohamadzadeh M, Van Dyke T, Banchereau J (2001) Lipopolysaccharides from distinct pathogens induce different classes of immune responses in vivo. J Immunol 167: 5067– 5076.
Oviedo-Boyso J, Valdez-Alarcón JJ, Cajero- Juárez M, Ochoa-Zarzosa A, López-Meza JE, Bravo-Patiño A, Baizabal-Aguirre VM (2007) Innate immune response of bovine mammary gland to pathogenic bacteria responsible for mastitis. J Infect 54: 399-409.
Akira S, Takeda K (2004) Toll-like receptor signalling. Nat Rev Immunol 4: 499-511.
Oviedo-Boyso J, Cortés-Vieyra R, Huante- Mendoza A, Yu HB, Valdez-Alarcón JJ, Bravo- Patiño A, Cajero-Juárez M, Finlay BB, Baizabal Aguirre VM (2011) The phosphoinositide-3- kinase-Akt signaling pathway is important for Staphylococcus aureus internalization by endothelial cells. Infect Immun 79: 4569–4577.
Cortés-Vieyra R, Silva-García O, Oviedo-Boyso J, Huante Mendoza A, Bravo-Patiño A, Valdez- Alarcón JJ, Finlay BB, Baizabal-Aguirre VM (2015) The glycogen synthase kinase 325. Cortés-Vieyra R, Silva-García O, Oviedo- Boyso J, Huante Mendoza A, Bravo-Patiño A, Valdez-Alarcón JJ, Finlay BB, Baizabal- Aguirre VM (2015) The glycogen synthase kinase 3α and b isoforms differentially regulates interleukin12p40 expression in endothelial cells stimulated with peptidoglycan from Staphylococcus aureus. PLoS ONE 10(7): e0132867. doi:10.1371/journal. pone.0132867.
Watford WT, Moriguchi M, Morinobu A, O’Shea JJ 2003 The biology of IL-12: coordinating innate and adaptive immune responses. Cytokine Growth Factor Rev 14: 361–368.