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2014, Número 4

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Enf Infec Microbiol 2014; 34 (4)


Primer estudio molecular de Streptococcus agalactiae serotipo V en Misiones, Argentina

Laczeski M, Novosak M, Quiroga M, Vergara M

Idioma: Español
Referencias bibliográficas: 44
Paginas: 132-134
Archivo PDF: 207.01 Kb.


RESUMEN

Antecedentes. Streptococcus agalactiae (SGB) serotipo V, es uno de los serotipos más frecuentemente asociado a infección invasiva en adultos y neonatos. Sus factores de virulencia y su asociación a resistencia a macrólidos, ha sido ya destacada.
Material y métodos. Se estudiaron 14 cepas de SGB serotipo V de un total de 197. Se utilizó PCR convencional para la búsqueda de genes de virulencia y de resistencia a macrólidos. La sensibilidad a estos antimicrobianos se determinó por D-test y CIM.
Resultados. Los genes bca y hylB se detectaron en el 100% de las cepas. En 78.6% de ellas se detectaron 4 o más genes asociados a la virulencia. El 21.43 % de las cepas presentó resistencia a macrólidos (un fenotipo constitutivo cMLSB y 2 fenotipos inducibles iMLSB) y en ellos se identificaron los genes ermB, ermTR y mefA.
Conclusiones. La frecuencia elevada de genes asociados a la virulencia y la resistencia a macrólidos detectada en este estudio de SGB serotipo V, nos alienta a reforzar las estrategias de vigilancia epidemiológica de estas cepas, dado el impacto que pudieran tener en el tratamiento de infecciones en alérgicos a penicilina y en el diseño de estrategias vacunales.


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