Avila-Luna A, Bueno-Nava A

Idioma: Español
Referencias bibliográficas: 29
Paginas: 19-24
Archivo PDF: 294.51 Kb.

RESUMEN

Los ganglios basales (GB) están asociados a las funciones motoras y no motoras. El neoestriado forma parte de los GB y su función es críticamente modulada por la dopamina a través de la activación de receptores D₁ y D₂ postsinápticos expresados en las neuronas espinosas de tamaño mediano y que median la vía directa estriadonigral e indirecta estriadopalidal, respectivamente. La liberación de dopamina estriatal, modulada por la administración de agonistas y antagonistas dopaminérgicos, es explicada a través del sistema de retroalimentación negativa, que involucra receptores pre- y postsinápticos. El estudio del sistema dopaminérgico estriatal puede contribuir al entendimiento en la fisiología y disfunción de los GB. La presente revisión tiene el propósito de explicar la participación dopaminérgica estriatal en los GB y la función motora

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