Falcón GJJ, Gazga UC, González TC, Nájera MO

Idioma: Español
Referencias bibliográficas: 26
Paginas: 92-99
Archivo PDF: 338.17 Kb.

RESUMEN

La leptina se ha clasificado como una citocina, debido a su estructura y a la de su receptor. Como parte de sus funciones biológicas, la leptina participa en el metabolismo de los lípidos y la glucosa, la síntesis de los glucocorticoides, la insulina, y en la transmisión sináptica. Asimismo, posee capacidad reguladora sobre la fagocitosis, la producción de citocinas pro-inflamatorias por células efectoras del sistema inmune, y la proliferación de los linfocitos y las células dendríticas, por lo que se le considera como una hormona pleiotrópica, cuya importancia tanto a nivel del estatus nutricional como en el sistema inmunológico hace relevante la posibilidad de emplear esta proteína con fines terapéuticos. Sin embargo, se ha señalado que el aumento de la concentración de leptina se asocia a ciertas enfermedades autoinmunes.

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