2007, Número 3
<< Anterior Siguiente >>
Med Int Mex 2007; 23 (3)
Trasplante de hígado en pacientes con cirrosis hepática alcohólica
José Gutiérrez SJ, Cruz TL
Idioma: Español
Referencias bibliográficas: 39
Paginas: 224-228
Archivo PDF: 108.13 Kb.
RESUMEN
El trasplante de hígado es una opción terapéutica pocas veces contemplada en pacientes que padecen cirrosis hepática alcohólica. Un motivo importante de rechazo de los cirujanos es que los consideran como poco probables para su rehabilitación posterior, por lo que tienen baja prioridad a pesar de que la cirrosis hepática alcohólica ocupa uno de los primeros lugares dentro de las enfermedades del hígado. Los resultados obtenidos por varios grupos de investigadores en el mundo han demostrado que el trasplante hepático en quienes padecen cirrosis hepática alcohólica tiene mejores posibilidades de sobrevivencia que en los que padecen otro tipo de enfermedad hepática y reciben trasplante de hígado. Buena parte del éxito del trasplante depende del soporte psicológico y familiar que reciba el paciente para evitar en lo posible la ingestión de etanol. De esta forma, un paciente con cirrosis hepática alcohólica puede solicitar el trasplante, siempre y cuando reciba atención integral que contemple la esfera médica, psicológica y social.
REFERENCIAS (EN ESTE ARTÍCULO)
Roizen R, Kerr WC, Filmore KM. Cirrhosis mortality and per capita consumption of distilled spirits. United States 1949-1994 analysis. BMJ 1999;319:666-72.
McMaster P. Transplantation for alcoholic liver disease in an era of organ shortage. Lancet 2000;355:424-8.
Neuberger J. Transplantation for alcoholic liver disease: a perspective from Europe. Liver Transplant Surg 1998;4: S51.
Neuberger J, Adams D, McMaster P. Assessing priorities for allocation of donor liver grafts: survey of public and clinicians. Br Med J 1998;317:172-80.
Neuberger J, Schulz KH, Day C. Transplantation for alcoholic liver disease. J Hepatol 2002;36:130-6.
Tome S, Lucey MR. Current management of alcoholic liver disease. Aliment Pharmacol Ther 2004;19:1-15.
Veldt BJ, Laine F. Indication of liver transplantation in severe alcoholic liver cirrhosis: qualitative evaluation and optimal timing. J Hepatol 2002;36:93-108.
Burra P, Mioni D, Cecchetto A. Histological features after liver transplantation in alcoholic cirrhosis. J Hepatol 2001;34:716-22.
Hoofnagle JH, Kresina T, Fuller RK. Liver transplantation for alcoholic liver disease: executive statement and recommendations. Liver Transplant Surg 1997;3:347-52.
Merion RM, Wolfe RA, Dykstra DM, Leichtman AB. Longitudinal assessment of mortality risk among candidates for liver transplantation. Liver Transpl 2003;9:12-25.
National Institutes of Health Consensus. National Institutes of Health Consensus Development Conference statement: liver transplantation. Hepatology 1984;3:107S.
Walter M, Scholler G, Moyzes D. Psychsocial prediction of abstinence from ethanol in alcoholic recipients following liver transplantation. Transplant Proc 2002;34:1239-48.
Tome S, Lucey MR. Timing of liver transplantation in alcoholic cirrhosis. J Hepatol 2003;39:302-10.
Pageaux GP, Perney P, Larrey D. Liver transplantation for alcoholic liver disease. Addict Biol 2001;6:301-12.
Bruix J, Llovet JM. Prognostic prediction and treatment strategy in hepatocellular carcinoma. Hepatology 2002;35:519-27.
Wiesner R, Edwards E, Freeman R. Model for endstage liver disease (MELD) and allocation of donor livers. Gastroenterology 2003;124:91-104.
Kamath PS, Wiesner RH, Malinchoc M. A model to predict survival in patients with end-stage liver disease. Hepatology 2001;33:464-9.
Poynard T, Barthelmy P, Fratte S. Evaluation of efficacy of liver transplantation in alcoholic cirrhosis by a case control study and simulated controls. Lancet 1994;344:502-11.
Sherman D, Williams R. Liver transplantation for alcoholic liver disease. J Hepatol 1995;23:474-81.
Kenngott S, Gerbes AL, Schauer R, Bilzer M. Rapid development of esophageal squamous cell carcinoma after liver transplantation for alcohol-induced cirrhosis. Transplant Int 2003;16:639-49.
Burroughs A, Hochhauser D, Meyer T. Systemic treatment and liver transplantation for hepatocellular carcinoma: two ends of the terapeuthic spectrum. Lancet Oncol 2004;5:409-18.
Veilhan LA, Adam R. Alcoholic liver cirrhosis. Treatment of hepatocellular carcinoma. Presse Med 2001;30:1170-82.
Anand A, Ferraz-Neto B, Nightingale PJ. Liver transplantation for alcoholic liver disease. Evaluation of a selection protocol. Hepatology 1997;25:1478-84.
Mackie J, Groves K, Hoyle A. Orthotopic liver transplantation for alcoholic liver disease: a retrospective analysis of survival, recidivism, and risk factors predisposing to recidivism. Liver Transpl 2001;7:418-23.
Tome S, Martinez-Rey C, Gonzalez-Quintela A. Influence of superimposed alcoholic hepatitis on the outcome of liver transplantation for end-stage alcoholic liver disease. J Hepatol 2002;36:793-802.
Pereira SP, Williams R. Alcohol relapse and functional outcome after liver transplantation for alcoholic liver disease. Liver Transpl 2001;7:204-5.
Pageaux GP, Bismuth M, Perney P. Alcohol relapse after liver transplantation for alcoholic liver disease: does it matter? J Hepatol 2003;38:629-39.
Fuller RK. Definition and diagnosis of relapse to drinking. Liver Transplant Surg 1997;3:258-63.
Tang H, Boulton R, Gunson B, Hubscher S, et al. Patterns of alcohol consumption after liver transplantation. Gut 1998;43:140-53.
Berlakovich GA, Rockenschaub S, Taucher S. Underlying disease as a predictor for rejection after liver transplantation. Arch Surg 1998;133:167-75.
Farges O, Saliba F, Farhmant H. Incidence of rejection and infection after liver transplantation as a function of the primary disease: possible influence of alcohol and polyclonal immunoglobulins. Hepatology 1996;23:240-51.
Platz KP, Mueller AR, Spree E. Liver transplantation for alcoholic cirrhosis. Transplant Int 2000;13:S127.
Dam M, Burra P, Tedeschi U. Regional cerebral blood flow changes in patients with cirrhosis assessed with 99mTc-HMPAO single-photon emission computed tomography: effect of liver transplantation. J Hepatol 1998;29:78-85.
Haagsma EB, Hagens VE, Schaapveld M. Increased cancer risk after liver transplantation. Hepatology 2001;34:84-97.
De Bona M, Ponton P, Ermani M. The impact of liver disease and medical complications on quality of life and psychosocial distress before and after liver transplantation. J Hepatol 2000;33:609-17.
Cowling T, Jennings LW, Jung GS, Goldstein RM, et al. Comparing quality of life following liver transplantation for Laennaec versus non-Laennaec’s patients. Clin Transpl 2000;14:115-21.
Pereira SP, Howard LM, Muiesan P, Rela M, et al. Quality of life after liver transplantation for alcoholic liver disease. Liver Transpl 2000;6:762-70.
Berlakovic GA, Langer F, Freundorfer E. General compliance after liver transplantation for alcoholic cirrhosis. Transplant Int 2000;13:129-37.
Cowling T, Jennings LW, Goldstein RM. Societal reintegration after liver transplantation. Findings in alcohol-related and nonalcohol related transplant recipients. Ann Surg 2004;239:93- 107.