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2007, Número 1

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Cir Gen 2007; 29 (1)


Tumores del estroma gastrointestinal. Presentación de una serie de tres casos de localización gástrica

Pérez MAG, Ruiz JI, Roesch DF, Martínez FS, Martínez JA

Idioma: Español
Referencias bibliográficas: 31
Paginas: 50-53
Archivo PDF: 135.95 Kb.


RESUMEN

Los tumores estromales gastrointestinales son una entidad poco frecuente, que se diferencian de otros tumores mesenquimatosos del tracto gastrointestinal con base en estudios inmunohistoquímicos basados en el KIT CD 117, que han permitido comprender mejor su biología y los mecanismos genéticos involucrados. Su detección clínica y manejo oportuno son de gran importancia debido a que entre el 10 y 30% producen metástasis hepáticas e implantes peritoneales, que requieren, además del manejo quirúrgico, el empleo de terapias blanco moleculares como los agentes inhibidores selectivos de tirosin-quinasa (mesilato de imatinib), con lo cual se ha logrado elevar la sobrevida a 5 años, hasta en 43%, en pacientes con enfermedad metastásica.
Se presenta una serie de tres casos de tumores estromales de localización gástrica, atendidos en el Hospital Español de la ciudad de Veracruz, en los cuales se analizan los resultados de los estudios morfológicos y la terapéutica empleada. Se encontró una relación familiar estrecha en dos de ellos.


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