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Colegio de Medicina Interna de México.

2021, Number 2

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Med Int Mex 2021; 37 (2)

Nesidioblastosis in adults

García-Rodríguez JA, Salcido-Carmona CA, Ortega-Valdez CA, Maldonado-García EL

Language: Spanish
References: 31
Page: 267-274
PDF size: 386.29 Kb.


ABSTRACT

Background: Among the causes of hyperinsulinemic hypoglycemia in adults, nesidioblastosis accounts for 7%.
Clinical case: A 43-year-old female patient with a history of diabetes mellitus and primary arterial hypertension that began with hypoglycaemia that persisted for 5 months; insulin was suspended. Patient was hospitalized due to generalized tonic-clonic seizure and hypoglycaemia of 10 mg/dL, fasting test was performed with hypoglycemia at 8 h of 65 mg/dL, insulin 14.2 µUI/mL and peptide C 2.52 ng/mL; she was referred at the third level hospital, where nuclear magnetic resonance and selective intra-arterial pancreatic stimulation were performed with inconclusive results. In the medical surgical session it was decided to perform distal pancretectomy. Histopathological report was of islet cell hyperplasia of Langerhans, immunohistochemistry: chromogranin A +, synaptophysin +, neuronal enolase +, CD 56 + and Ki67 ‹ 1%.
Conclusions: Nesidioblastosis in adults is a rare disease with an increased incidence.


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