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2020, Number 3

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VacciMonitor 2020; 29 (3)

Immunotherapy with mite allergens in patients with allergic rhinitis and obstructive sleep apnea

Rodríguez-Santos O, García-Asensi A, del Valle-Monteagudo N, Galeana-Río R, Flores-Silverio Z

Language: Spanish
References: 20
Page: 103-108
PDF size: 264.57 Kb.


ABSTRACT

To confirm the presence of obstructive sleep apnea (OSA) in allergic rhinitis (AR), cardiorespiratory polygraphy (CRP) was performed, and to treat both conditions, the allergen specific immunotherapy (ASIT) was used in order to change their course. Descriptive study in the universe of patients from “Previsora” polyclinic Allergology service, Camagüey, Cuba was carried-out from December 2018 to March 2020. 326 patients were selected in consecutive order of attendance at the consultation, taking into account the criteria: ≥5 years with AR, suspicion of OSA and positive skin test to: Dermatophagoides pteronyssinus, Dermatophagoides siboney and Blomia tropicalis, supplied by the “National Center for Biopreparations” in Cuba. All patients received ASIT for ≥10 months and CRP was performed before and after ASIT. The CRP results were taken from the automatic scoring of the ApneaLink AirTM device (Resmed Corp., Australia), validated to study OSA at home. The skin test and CRP results were evaluated before and after the ASIT. In addition, the assessment of the ASIT efficacy according to criteria of patients and professionals was performed. The sample was made-up of 152 female patients (46.6%) and 174 males (53.4%); those with 5 to 6 mm wheal were the most represented (p=0.04). There was decrease in OSA severity levels after ASIT (p=0.025). The ASIT efficacy was proved with a significant number of improvements (p=0.012). CRP provides the diagnosis of OSA in AR, and ASIT changes the course of both conditions.


REFERENCES

  1. Magliulo G, Iannella G, Ciofalo A, Polimeni A, de Vincentiis M, Pasquariello B, et al. Nasal pathologies in patients with obstructive sleep apnoea. Acta Otorrinolaringol Ital. 2019;39:250-6. doi: 10.14639/0392-100X-2173.

  2. Chirakalwasan N, Ruxrungtham K. The linkage of allergic rhinitis and obstructive sleep apnea. Asian Pac J Allergy Immunol. 2014;32(4):276-86.

  3. Zheng M, Wang X, Zhang L. Association between allergic and nonallergic rhinitis and obstructive sleep apnea. Curr Opin Allergy Clin Immunol. 2018;18(1):16-25. doi: 10.1097/ACI.0000000000000414.

  4. Cao Y, Wu S, Zhang L, Yang Y, Cao S. Association of allergic rhinitis with obstructive sleep apnea: A meta-analysis. Medicine (Baltimore). 2018;97(51):e13783. doi: 10.1097/MD.0000000000013783.

  5. Rodríguez-Santos O, García-Asensi A, Ponce-Álvarez C, Galeana-Ríos R, Jardines-Arciniega G, del Valle-Monteagudo N. Importancia de los alérgenos de ácaros domésticos en el diagnóstico de la rinitis alérgica con síndrome de apnea-hipopnea del sueño. VacciMonitor. 2019; 28(3):97-102.

  6. Hervada-Vidal X, Santiago-Pérez MI, Castillo-Salado C, Loyola-Elizondo E, Silva-Aycaguer LC. EPIDAT 3.1. Análisis epidemiológico de datos tabulados. Santiago de Compostela: Servicio de Información de la Consellería de Sanidade (Xunta de Galicia); 2006. Disponible en: https://www.sergas.es/Saude-publica/Epidat-3-1-descargar-Epidat-3-1-(espanol)

  7. Liu J, Zhang X, Zhao Y, Wang Y. The association between allergic rhinitis and sleep: A systematic review and meta-analysis of observational studies. PLoS ONE. 2020;15(2):e0228533. doi: 10.1371/journal.pone.0228533.

  8. Ha EK, Park JH, Lee SJ, Yon DK, Kim JH, Jee HM, et al. Shared and unique individual risk factors and clinical biomarkers in children with allergic rhinitis and obstructive sleep apnea syndrome. Clin Respir J. 2020;14(3):250-9. doi: 10.1111/crj.131244.

  9. Wongvilairat S, Assanasen P, Banhiran W, Tantilipikorn P, Bunnag C. The prevalence of high risk of obstructive sleep apnea in patients with allergic rhinitis. Asian Pac J Allergy Immunol. 2019;3: doi: 10.12932/AP-141218-0458.

  10. Nosetti L, Piacentini G, Macchi A, De Bernardi F, Simoncini D, Nicoloso M, et al. Nasal cytology in children with primary snoring and obstructive sleep apnoea syndrome. Int J Pediatr Otorhinolaryngol. 2019;122:133-7. doi: 10.1016/j.ijporl.2019.04.015.

  11. American Academy of Sleep Medicine. International Classification of Sleep Disorder: Diagnostic and Coding Manual. 2nd Ed. Westchester, New York: AASM; 2005.

  12. Lloberes P, Durán-Cantolla J, Martínez-García MA, Marín JM, Ferrer A, Corral J, et al. Diagnóstico y tratamiento del síndrome de apneas-hipopneas del sueño. Arch Bronconeumol. 2011;47:37810. doi: 10.1016/j.arbres.2011.01.001.

  13. Laaban JP, Mounier L, Roque d’Orbcastel O, Melloni B, Cornette A, Muir JF, et al. Assessment of recent weight history before instituting continuous positive airways pressure in a cohort of patients with severe obstructive sleep apnoea/hypopnea syndrome. Rev Mal Respir. 2014;31(1):41-7. doi: 10.1016/j.rmr.2013.05.001.

  14. Sociedad Española de Sueño. Guía española de Práctica Clínica. Utilización de los dispositivos de avance mandibular (DAM) en el tratamiento de pacientes adultos con síndrome de apneas-hipopneas del sueño. Zaragoza: Instituto Aragonés de Ciencias de la Salud; 2017. Disponible en: https://portal.guiasalud.es/wpcontent/uploads/2018/12/GPC_564_SES_Guia-DAM-2017_compl.pdf.

  15. Yang Q, Li H, Wu W, Huang X, Tu B, Ma Y, et al. Effect of continuous positive airway pressure on allergic rhinitis in patients with obstructive sleep apnea-hypopnea syndrome. Ther Clin Risk Manag. 2018;14:1507-13. doi: 10.2147/TCRM.S170548.

  16. Xu Z, Wu Y, Tai J, Feng G, Ge W, Zheng L, et al. Risk factors of obstructive sleep apnea syndrome in children. J of Otolaryngol - Head & Neck Surg. 2020;49:11. doi: 10.1186/s40463-020-0404-1.

  17. Gulotta G, Iannella G, Vicini C, Polimeni A, Greco A, de Vincentiis M, et al. Risk Factors for Obstructive Sleep Apnea Syndrome in Children: State of the Art. Int J Environ Res Public Health. 2019;16(18):33235. doi: 10.3390/ijerph16183235.

  18. Marcuccio G, Di Bari M, Precenzano F, Operto FF, Bitetti I, Motta G, Testa D. Relationship between sleep quality and rhinitis in children: role of medical treatment with isotonic and hypertonic salines. Minerva Pediatr. 2019;25: doi: 10.23736/S0026-4946.

  19. Johnston J, McLaren H, Mahadevan M, Douglas RG. Clinical characteristics of obstructive sleep apnea versus infectious adenotonsillar hyperplasia in children. Int J Pediatr Otorhinolaryngol. 2019;116:177-80. doi: 10.1016/j.ijporl.2018.11.004.

  20. Yang Q, Li H, Wu W, Huang X, Tu B, Ma Y, et al. Effect of continuous positive airway pressure on allergic rhinitis in patients with obstructive sleep apnea-hypopnea syndrome. Ther Clin Risk Manag. 2018;14:1507-13. doi: 10.2147/TCRM.S170548.




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