medigraphic.com
Instituto Nacional de Neurología y Neurocirugía

2020, Number 3

<< Back Next >>

Arch Neurocien 2020; 25 (3)

Metabolism and effect of dehydroepiandrosterone (DHEA) in the central nervous system

Márquez-Flores MÁ, Sandoval H, Pérez-Neri I, Ríos C, Diéguez-Campa-Carlos E

Language: Spanish
References: 20
Page: 51-58
PDF size: 432.10 Kb.


ABSTRACT

Dehydroepiandrosterone (DHEA) is not only an active steroid, but it also leads to nongenomic effects. More findings on steroid synthesis in the central nervous system (CNS) have been reported showing that the differences with endocrine organs are minimal. Maybe the explanation of the multiple effects of a single molecule as DHEA lies in those pathways. In the CNS, those actions include neuroprotection, dendrite growth, apoptosis, catecholamine synthesis and secretion, as well as antioxidant, anti-inflammatory, and antiglucocorticoid functions. Changes in DHEA serum concentration are associated with several diseases. This concentration decreases with age from its maximum in the young people to its minimum when some aging-related disorders are increasingly prevalent. Both DHEA and other steroids generate some effects, but they may also be metabolized to other active molecules, increasing the complexity of their effect; thus, it is essential to describe those metabolic interactions to understand the findings regarding these messengers better.


REFERENCES

  1. Maninger N, Wolkowitz OM, Reus VI, Epel ES, Mellon SH. Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS). Front Neuroendocrinol. 2009; 30(1):65-91. DOI: 10.1016/j. yfrne.2008.11.002

  2. Pérez-Neri I, Ríos C. The role of DHEA in mental disorders. In: Watson R, editor. DHEA in Human Health and Aging. Boca Raton: CRC Press. 2011; 239-252. ISBN: 9781439838839

  3. Bélanger N, Grégoire L, Bédard PJ, Di Paolo T. DHEA improves symptomatic treatment of moderately and severely impaired MPTP monkeys. Neurobiol Aging. 2006; 27(11):1684-1693. DOI: 10.1016/j.neurobiolaging.2005.09.028

  4. Shealy CN. A review of dehydroepiandrosterone (DHEA). Integr Psych Behav. 1995;30(4):308-313. DOI: 10.1007/BF02691603

  5. Cascio C, Prasad VV, Lin YY, Lieberman S, Papadopoulos V. Detection of P450c17-independent pathways for dehydroepiandrosterone (DHEA) biosynthesis in brain glial tumor cells. Proc Natl Acad Sci U S A. 1998; 95(6):2862- 67. DOI: 10.1073/pnas.95.6.2862

  6. Zwain IH, Yen SS. Dehydroepiandrosterone: biosynthesis and metabolism in the brain. Endocrinology. 1999;140(2):880-7. DOI: 10.1210/endo.140.2.6528

  7. Baulieu EE. Neurosteroids: a new function in the brain. Biol Cell. 1991; 71(1-2):3-10. DOI: 10.1016/0248-4900(91)90045-o

  8. Brown MS, Kovanen PT, Goldstein JL. Receptor-mediated uptake of lipoprotein-cholesterol and its utilization for steroid synthesis in the adrenal cortex. Recent Prog Horm Res. 1979; 35:215-57. DOI: 10.1016/b978-0-12-571135-7.50009-6.

  9. Gwynne JT, Strauss JF. The role of lipoproteins in steroidogenesis and cholesterol metabolism in steroidogenic glands. Endocr Rev. 1982; 3:299-329. DOI: 10.1210/edrv-3-3-299

  10. Beins DM, Vining R, Balasubramaniam S. Regulation of neutral cholesterol esterase and acyl-CoA : cholesterol acyltransferase in the rat adrenal gland. Biochem J. 1982; 202(3):631-637. DOI: 10.1042/bj2020631

  11. Lin D, Sugawara T, Strauss JF, Clark BJ, Stocco DM, Saenger P, Rogol A, Miller WL. Role of steroidogenic acute regulatory protein in adrenal and gonadal steroidogenesis. Science. 1995; 267(5205):1828-31. DOI: 10.1126/science.7892608

  12. Strott CA. The search for the elusive adrenal steroidogenic “regulatory” protein. Trends Endocrinol Metab. 1990; 1(6):31214. https://doi.org/10.1016/1043-2760(90)90070-J

  13. Di Blasio AM, Voutilainen R, Jaffe RB, Miller WL. Hormonal regulation of messenger ribonucleic acids for P450scc (cholesterol side-chain cleavage enzyme) and P450c17 (17 ahydroxylase/ 17, 20-lyase) in cultured human fetal adrenal cells. J Clin Endocrinol Metab. 1987; 65(1):170-5. DOI: 10.1210/jcem-65-1-170

  14. Pérez-Neri I, Montes S, Ojeda-López C, Ramírez-Bermúdez J, Ríos C. Modulation of neurotransmitter systems by dehydroepiandrosterone and dehydroepiandrosterone sulfate: mechanism of action and relevance to psychiatric disorders. Prog Neuropsychopharmacol Biol Psychiatry. 2008; 32(5):111830. DOI: 10.1016/j.pnpbp.2007.12.001

  15. Harris DS, Wolkowitz OM, Reus VI. Movement disorder, memory, psychiatric symptoms and serum DHEA levels in schizophrenic and schizoaffective patients. World J Biol Psychiatry. 2001; 2:99-102. DOI: 10.3109/15622970109027500

  16. Mishra M, Singh R, Sharma D. Antiepileptic action of exogenous dehydroepiandrosterone in iron-induced epilepsy in rat brain. Epilepsy Behav.2010; 264-71. DOI: 10.1016/j.yebeh.2010.06.048

  17. Galimberti CA, Magri F, Copello F, Arbasino C, Cravello L, Casu M, et al. Seizure Frequency and cortisol and dehydroepiandrosterone sulfate (DHEAS) levels in women with epilepsy receiving antiepileptic drug reatment. Epilepsia.2005; 46(4):517-23. DOI: 10.1111/j.0013-9580.2005.59704.x

  18. Zajda ME, Krzascik P, Hill M, Majewska MD. Psychomotor and rewarding properties of the neurosteroids dehydroepiandrosterone sulphate and androsterone: effects on monoamine and steroid metabolism. Acta Neurobiol Exp (Wars). 2012; 72(1):65-79. PMID: 22508085

  19. Kalimi M, Shafagoj Y, Loria R, Padgett D, Regelson W. Antiglucocorticoid effects of dehydroepiandrosterone (DHEA). Mol Cel Biochem. 1994; 131(2):99-104. DOI: 10.1007/BF00925945

  20. Aly HF, Metwally FM, Ahmed HH. Neuroprotective effects of dehydroepiandrosterone (DHEA) in rat model of Alzheimer’s disease. Acta Biochim Pol. 2011; 58(4):513-20. http://www.actabp.pl/pdf/4_2011/513.pdf




2020     |     www.medigraphic.com