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Instituto Nacional de Neurología y Neurocirugía

2020, Número 3

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Arch Neurocien 2020; 25 (3)


Epilepsia del lóbulo temporal pos-estatus epilepticus por pilocarpina, y conexiones hipocampo-talamocorticales

López-Hernández ME, Solís H

Idioma: Español
Referencias bibliográficas: 147
Paginas: 33-50
Archivo PDF: 747.65 Kb.


RESUMEN

La Epilepsia del Lóbulo Temporal (ELT) es el tipo más frecuente de las epilepsias crónicas parciales y refractaria al tratamiento médico en el adulto. Es un trastorno de la excitabilidad neuronal cuya característica es que las crisis se inician en cualquier parte del lóbulo temporal y en el que se involucran diferentes procesos celulares y moleculares de distintas redes neuronales tanto corticales como subcorticales. El objetivo de esta revisión es considerar varios de los aspectos generales y específicos de la epilepsia del lóbulo temporal (ELT) en el humano y establecer posibles relaciones con los hallazgos obtenidos principalmente en el modelo experimental de ratas pos-status epilepticus (SE) por pilocarpina en nuestro laboratorio, con la información que reporta la bibliografía. En particular, analizar varios de los diferentes cambios que se establecen en los mecanismos celulares y redes neuronales en el hipocampo, tálamo y corteza cerebral. Con la amplia investigación que se realiza sobre el tema, hemos identificado diversos y complejos procesos que suceden, en las diferentes estructuras encefálicas, durante el desarrollo de la epileptogénesis, sin embargo, aún tenemos muchas preguntas por resolver utilizando el modelo experimental de crisis convulsivas y el estudio de la epilepsia desde un punto de vista clínico.


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