2020, Number 1
<< Back Next >>
Invest Medicoquir 2020; 12 (1)
Evolution of critical patients treated with renal replacement therapies
Quiles GL, Hernández FE, Abdo CA
Language: Spanish
References: 20
Page:
PDF size: 256.58 Kb.
ABSTRACT
Introduction: Acute renal dysfunction is one of the most serious complications of the critical patient, has a high incidence of more than 55% and a mortality of around 40%. Continuous renal replacement therapies are extracorporeal support methods that replace the glomerular filtration function continuously.
Methods. A retrospective and observational study was performed in patients with acute renal dysfunction treated with renal replacement therapy, admitted to the intensive care service of the Surgical Medical Research Center in the period from January 2015 to September 2019. The risk factors associated with mortality and recovery of renal function were studied.
Results. 126 patients were studied; The main risk factors associated with acute renal failure were sepsis (85,7%) and arterial hypotension (95,2%). The overall mortality in the intensive care unit was 59,5%, the main cause of death being the multi-organ failure. The most affected systems were cardiovascular (95,2%) and respiratory (69%). The mean Sepsis-related Organ Failure Assessment score was 12 ± 2,5. Of the survivors upon discharge from the intensive care unit, it stands out that only 13,7% were left with intermittent hemodialysis dependence. The factors most related to the recovery of renal function were creatinine at admission and the presence of anuria.
Conclusions. The mortality of critical patients treated with renal replacement therapy is still high. Oliguric and traumatic patients had better survival. Age over 60 years and the Sepsis-related Organ Failure Assessment score over 11 points were independent risk factors for mortality.
REFERENCES
Liaño F, Junco E, Pascual J, Madero R, Verde E. The spectrum of acute renal failure in the intensive care unit compared with that seen in other settings. The Madrid Acute Renal Failure Study Group. Kidney Int Suppl. 1998;66: S16---24.
Uchino S, Kellum J, Bellomo R, Doig S, Morimatsu H, Morgera S, et al., Beginning and Ending Supportive Therapy for the Kidney (BEST Kidney) Investigators. Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA.2005; 294:813---8.
Herrera-Gutiérrez ME, Seller-Pérez G, Maynar-Moliner J,Sanchez-Izquierdo-Riera JA. Epidemiology of acute kidney Failure in Spanish ICU. Multicenter prospective study FRAMI. Med Intensiva.2015; 30:260---7.
Hoste E, Schurgers M. Epidemiology of acute kidney injury: how big is the problem? Crit Care Med. 2008;36(4 Suppl): S146---51.
Morgera S, Schneider M, Neumayer H. Long-term outcomes after acute kidney injury. Crit Care Med. 2008;36(4 Suppl): S193---7.
Ronco C, Bellomo R, Homel P, Brendolan A, Dan M, Piccinni P, et al. Effects of different doses in continuous veno-venous hemofiltration. Lancet.2000; 356:26---30.
Joannidis M, Metnitz P. Epidemiology and natural history of acute renal failure in the ICU. Crit Care Clin. 2005;21: 239---49.
Bagshaw S. Epidemiology of renal recovery after acute renal failure. CurrOpinCrit Care.2006; 12:544---50.
Schiffl H. Renal recovery from acute tubular necrosis requiring renal replacement therapy: a prospective study in critically ill patients. Nephrol Dial Transplan.2006; 21:1248---52.
Dellinger RP, Carlet JM, Masur H, Gerlach H, Calandra T, Cohen J, et al. Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Intensive Care Med. 2004; 30:536---55.
Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P, Acute Dialysis Quality Initiative workgroup. Acute renal failuredefinition, outcome measures, animal models, fluid Therapy and information technology needs: the Second International Consensus Conferences of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care Med. 2004;8: R204---12.
Ostermann ME, Taube D, Morgan CJ, Evans TW. Acute renal failure following cardiopulmonary bypass: a changing picture. Intensive Care Med. 2000; 26:565---71.
Druml W, Lax F, Grimm G, Schneeweiss B, Lenz K, Laggner AN. Acute renal failure in the elderly 1975-1990. ClinNephrol.1994; 41:342---9.
Turney JH, Marshall DH, Brownjohn AM, Ellis CM, Parsons FM. The evolution of acute renal failure, 1965-1998.Q J Med. 1990; 74:83---104.
Bisenbach G, Zasgornik J, Kaiser W, Grafinger P, Study U, Necek S. Improvement in prognosis of patients with acute renal failure over a period of 15 years: an analysis of 710 cases in a dyalisis center. Am J Nephrol.1992; 12:319---25.
Bellomo R, Honore PM, Matson JR, Ronco C, Winchester J. Extracorporeal blood treatment methods in SIRS/sepsis. Consensus statement. Positionpaper. ADQI III Conference. Int J Artif Organs.2005; 28:450---8.
Palevsky PM, Zhang JH, O Connor TZ, Chertow GM, Crowley ST, Choudhury D, et al. The VA/NIH Acute Renal Failure Trial Network.Intensity of renal support in critically ill patients with acute kidney injury. N Engl J Med. 2008; 359:7---20.
Bellomo R, Cass A, Cole L, Finfer S, Gallagher M, Lo S, et al. Intensity of continuous renal-replacement therapy in critically ill patients. N Engl J Med. 2009; 361:1627---38.
Maynar-Moliner J, Sánchez-Izquierdo-Riera JA, Herrera- Gutiérrez M. Renal support in critically ill patients with acute kidney injury. N Engl J Med. 1960; 2008:359.
Chou Y, Huang T, Wu V, Wang C, Shiao C, Lai C, et al. Impact of timing of renal replacement therapy initiation on outcome of septic acute kidney injury.CritCare. 2011;15: R134.