Ortiz-Casillas MI, Alvizo-Rodríguez CR, Ortíz-García YM, Fuentes-Lerma MG, Gutiérrez-Angulo M, Mariaud-Schmidt RP

Language: Spanish
References: 65
Page: 77-83
PDF size: 636.95 Kb.

ABSTRACT

The oral cavity provides a warm and wet environment that makes normal oral flora extremely complex and conducive to colonization by fungi, viruses and bacteria, requiring multiple types of defenses to prevent infections. Antimicrobial peptides are important contributors to maintain the balance between health and disease, these perform several essential functions for the defense against microorganisms, which modifies the local inflammatory response and activates adaptive immunologic reaction mechanisms participating in the modulation of the immune response, which gives functional specificity and classifies them in different families being one of them the defensins. In this report a review of the functions and expression of the defensins and their relationship with the oral cavity.

REFERENCES

1. Abbas AK, Lichtman AH, Pillai S. Inmunología celular y molecular. 8a edición. España: Elsevier; 2015. p. 23.

2. Roa NS, Rodríguez A. Inmunidad celular y humoral frente a microrganismos cariogénicos y sus factores de virulencia en caries dental en humanos naturalmente sensibilizados. Univ Odontol. 2013; 32 (69): 61‑72.

3. Zlotnik A, Yoshie O. Chemokines: a new classification system and their role in immunity. Immunity. 2000; 12 (2): 121‑127.

4. DeFranco AL, Locksley RM, Robertson M. Immunity: The immune response to infectious and inflammatory disease. Yale J Biol Med. 2007; 80 (3): 137‑142.

5. Braff MH, Bardan A, Nizet V, Gallo RL. Cutaneous defense mechanisms by antimicrobial peptides. J Invest Dermatol. 2005; 125: 9‑13.

6. Schauber J, Gallo RL. Expanding the roles of antimicrobial peptides in skin: alarming and arming keratinocytes. J Invest Dermatol. 2007; 127 (3): 510‑512.

7. Koczulla R, Von Degenfeld G, Kupatt C, Krotz E, Zahler S, Gloe T et al. An angiogenic role for the human peptide antibiotic LL‑37/hCAP‑18. J Clin Invest. 2003; 111: 1665‑1672.

8. Wang G, Li X, Wang Z. APD3: the antimicrobial peptide database as a tool for research and education. Nucleic Acids Res. 2016; 44: 1087‑1093.

9. Avila EE. Functions of antimicrobial peptides in vertebrates. Curr Protein Pept Sci. 2017; 18 (11): 1098‑1119.

10. Lee SI, Kang SK, Jung HJ, Chun YH, Kwon YD, Kim EC. Muramyl dipeptide activates human beta defensin 2 and proinflammatory mediators through toll‑like receptors and NLRP3 inflammasomes in human dental pulp cells. Clin Oral Invest. 2015; 19 (6): 1419‑1428.

11. Jenssen H, Hamill P, Hancock REW. Peptide antimicrobial agents. Clin Microbiol Rev. 2006; 19 (3): 491‑511.

12. Shai Y. Mode of action of membrane active antimicrobial peptides. Biopolymers. 2002; 66 (4): 236‑248.

13. Brogden KA, Ackermann M, Huttner KM. Small, anionic, and charge‑neutralizing propeptide fragments of zymogens are antimicrobial. Antimicrob Agents Chemother. 1997; 41 (7): 1615‑1617.

14. Téllez GA, Castaño JC. Péptidos antimicrobianos. Infectio. 2010; 14 (1): 55‑67.

15. Sang Y, Blecha F. Antimicrobial peptides and bacteriocins: alternatives to traditional antibiotics. Anim Health Res Rev. 2008; 9 (2): 227‑235.

16. Dale BA, Tao R, Kimball JR, Jurevic RJ. Oral antimicrobial peptides and biological control of caries. BMC Oral Health. 2006; 6 Suppl 1: S13.

17. Pazgier M, Hoover DM, Yang D, Lu W, Lubkowski J. Human beta‑defensins. Cell Mol Life Sci. 2006; 63 (11): 1294‑1313.

18. Gallo RL, Hooper LV. Epithelial antimicrobial defense of the skin and intestine. Nat Rev Immunol. 2012; 12 (7): 503‑516.

19. Ganz T. Defensins: antimicrobial peptides of innate immunity. Nat Rev Immunol. 2003; 3 (9): 710‑720.

20. Castrillón LE, Palma A, Padilla C. Péptidos antimicrobianos: antibióticos naturales de la piel. Dermatología Rev Mex. 2007; 51 (2): 57‑67.

21. Dommisch H, Jepsen S. Diverse functions of defensins and other antimicrobial peptides in periodontal tissues. Periodontology 2000. 2015; 69: 96‑110.

22. US National Library of Medicine National Institutes of Health. Homo sapiens DEFA/DEFB. PubMed. 2019. [Último acceso el 21 de octubre 2019]. Disponible en: https://www.ncbi.nlm.nih.gov/gene/homosapiensDEFA/DEFB

23. Chen H, Xu Z, Peng L, Fang X, Yin X, Xu N et al. Recent advances in the research and development of human defensins. Peptides. 2006; 27 (4): 931‑940.

24. Ganz T, Selsted ME, Szklarek D, Harwig SSL, Deher K, Bainton DF et al. Defensins. Natural peptide antibiotics of human neutrophils. J Clin Invest. 1985; 76 (4): 1427‑1435.

25. Dawes C, Pedersen AM, Villa A, Ekström J, Proctor GB, Vissink A et al. The functions of human saliva: A review sponsored by the World Workshop on Oral Medicine VI. Arch Oral Biol. 2015; 60 (6): 863‑874.

26. Khurshid Z, Naseem M, Sheikh Z, Najeeb S, Shahab S, Zafar MS. Oral antimicrobial peptides: types and role in the oral cavity. Saudi Pharm J. 2016; 24 (5): 515‑524.

27. Sankaran S, Hart R, Dills C. Guardians of the gut: enteric defensins. Frontiers in Microbiology. 2017; 8: 647‑654.

28. Lehrer RI, Lu W. α‑Defensins in human innate immunity. Immunological Reviews. 2012; 245: 84‑112.

29. Falanga A, Nigro E, De Biasi MG, Daniele A, Morelli G, Galdiero S et al. Cyclic peptides as novel therapeutic microbicides: engineering of human defensin mimetics. Molecules. 2017; 22: 1217‑1232.

30. Nakamura K, Sakuragi N, Takakuwa A, Ayabe T. Paneth cell α‑defensins and enteric microbiota in health and disease. Biosci Microbiota Food Health. 2016; 35 (2): 57‑67.

31. Mattar EH, Almehdar HA, Yacoub HA, Uversky VN, Redwan EM. Antimicrobial potentials and structural disorder of human and animal defensins. Cytokine Growth Factor Rev. 2016; 28: 95‑111.

32. Selsted ME, Tang YQ, Morris WL, McGuire PA, Novotny MJ, Smith W et al. Purification, primary structures, and antibacterial activities of beta‑defensins, a new family of antimicrobial peptides from bovine neutrophils. J Biol Chem. 1993; 268 (9): 6641‑6648.

33. Diamond DL, Kimball JR, Krisanaprakornkit S, Ganz T, Dale BA. Detection of β‑defensins secreted by human oral epithelial cells. J Immunol Methods. 2001; 256 (1‑2): 65‑76.

34. Zhang G, Sunkara LT. Avian antimicrobial host defense peptides: From biology to therapeutic applications. Pharmaceuticals (Basel). 2014; 7 (3): 220‑246.

35. Klotman ME, Chang TL. Defensins in innate antiviral immunity. Nat Rev Immunol. 2006; 6 (6): 447‑456.

36. Scott MG, Hancock RE. Cationic antimicrobial peptides and their multifunctional role in the immune system. Crit Rev Immunol. 2000; 20 (5): 407‑431.

37. Harder J, Bartels J, Christophers E, Schroder JM. Isolation and characterization of human beta ‑defensin‑3, a novel human inducible peptide antibiotic. J Biol Chem. 2001; 276 (8): 5707‑5713.

38. Coretti L, Natale A, Cuomo M, Florio E, Keller S, Lembo F et al. The interplay between defensins and microbiota in Crohn’s Disease. Mediat Inflamm. 2017; 2017: 8392523.

39. Zhu BD, Feng Y, Huang N, Wu Q, Wang BY. Mycobacterium bovis bacille Calmette‑Guérin (BCG) enhances human beta‑defensin‑1 gene transcription in human pulmonary gland epithelial cells. Acta Pharmacol Sin. 2003; 24 (9): 907‑912.

40. Yang D, Liu ZH, Tewary P, Chen Q, de la Rosa G, Oppenheim JJ. Defensin participation in innate and adaptive immunity. Current Pharmaceutical Design. 2007; 13: 3131‑3139.

41. Cagliani R, Fumagalli M, Riva S, Pozzoli U, Comi GP, Menozzi G et al. The signature of long‑standing balancing selection at the human defensin β‑1 promoter. Genome Biology. 2008; 9 (9): 143‑154.

42. Sayama K, Komatsuzawa H, Yamasaki K, Shirakata Y, Hanakawa Y, Ouhara K et al. New mechanisms of skin innate immunity: ASK1‑mediated keratinocyte differentiation regulates the expression of b‑defensins, LL37, and TLR2. Eur J Immunol. 2005; 35 (6): 1886‑1895.

43. Fattorini L, Gennaro R, Zanetti M, Tan D, Brunori L, Giannoni F et al. In vitro activity of protegrin‑1 and beta‑defensin‑1, alone and in combination with isoniazid, against Mycobacterium tuberculosis. Peptides. 2004; 25: 1075‑1077.

44. Sun L, Finnegan CM, Kish‑Catalone T, Blumenthal R, Garzino‑Demo P, La Terra Maggiore GM et al. Human beta‑defensins suppress human immunodeficiency virus infection: potential role in mucosal protection. J Virol. 2005; 79 (22): 14318‑14329.

45. Prado E. Defensinas humanas: ¿profilaxis y terapia contra el VIH? Gac Méd Méx. 2006; 142 (5): 431‑433.

46. Bullard RS, Gibson W, Bose SK, Belgrave JK, Eaddy AC, Wright CJ et al. Functional analysis of the host defense peptide human beta defensin‑1: new insight into its potential role in cancer. Mol Immunol. 2008; 45: 839‑848.

47. Diamond G, Beckloff N, Weinberg A, Kisich KO. The roles of antimicrobial peptides in innate host defense. Curr Pharm Des. 2009; 15 (21): 2377‑2392.

48. Sorsa T, Gursoy UK, Nwhator S, Hernandez M, Tervahartiala T, Leppilahti J et al. Analysis of matrix metalloproteinases in gingival crevicular fluid (GCF), mouthrinse and saliva for monitoring periodontal diseases. Periodontology 2000. 2016; 70: 142‑163.

49. Zhao C, Wang I, Lehrer RI. Widespread expression of β‑defensin hBD‑1 in human secretory glands and epithelial cells. FEBS Letters. 1996; 396: 319‑322.

50. Diamond G, Beckloff N, Ryan LK. Host defense peptides in the oral cavity and the lung: similarities and differences. J Dent Res. 2008; 87 (10): 915‑927.

51. Mizukawa N, Sugiyama K, Ueno T, Mishima K, Takagi S, Sugahara T. Defensin‑1, an antimicrobial peptide present in the saliva of patients with oral diseases. Oral Dis. 1999; 5: 139‑142.

52. Sawaki K, Mizukawa N, Yamaai T, Yoshimoto T, Nakano M, Sugahara T. High concentration of betadefensin‑ 2 in oral squamous cell carcinoma. Anticancer Res. 2002; 22 (4): 2103‑2107.

53. Bonass WA, High AS, Owen PJ, Devine DA. Expression of β‑defensin genes by human salivary glands. Oral Microbiol Immunol. 1999; 14 (6): 371‑374.

54. Bals R, Wang X, Wu Z, Freeman T, Bafna V, Zasloff M et al. Human β‑defensin 2 is a salt‑sensitive peptide antibiotic expressed in human lung. J Clin Invest. 1998; 102 (5): 874‑880.

55. McKay MS, Olson E, Hesla MA, Panyutich A, Ganz T, Perkins S et al. Immunomagnetic recovery of human neutrophil defensins from the human gingival crevice. Oral Microbiol Immunol. 1999; 14 (3): 190‑193.

56. Navarra CO, Robino A, Pirastu N, Bevilacqua L, Gasparini P, Di Lenarda R et al. Caries and innate immunity: DEFB1 gene polymorphisms and caries susceptibility in genetic isolates from north‑eastern ital. Caries Research. 2016; 50: 589‑594.

57. Goeke E, Kist S, Schubert S, Hickel R, Huth K, Killmuss M. Sensitivity of caries pathogens to antimicrobial peptides related to caries risk. Clin Oral Investig. 2018; 22 (7): 2519‑2525.

58. Lee JK, Chang SW, Perinpanayagam H, Lim SM, Park YJ, HanSH et al. Antibacterial efficacy of a human β‑defensin‑3 peptide on multispecies biofilms. J Endod. 2013; 39 (12): 1625‑1629.

59. Farges JC, Alliot‑Licht B, Renard E, Ducret M, Gaudin A, Smith AJ et al. Dental pulp defence and repair mechanisms in dental caries. Mediators Inflamm. 2015; 2015: 230251.

60. Hahn CL, Best AM, Tew JG. Cytokine induction by Streptococcus mutans and pulpal pathogenesis. Infect Immun. 2000; 68 (12): 6785‑6789.

61. Hosokawa Y, Hirao K, Yumoto H, Washio A, Nakanishi T, Takegawa D et al. Functional roles of NOD1 in odontoblasts on dental pulp innate immunity. Biomed Res Int. 2016; 2016: 9325436.

62. Cooper PR, Holder MJ, Smith AJ. Inflammation and regeneration in the dentin‑pulp complex: a double‑edged sword. J Endod. 2014; 40: 46‑51.

63. Nishimura E, Eto A, Kato M, Hashizume S, Imai S, Nisizawa T et al. Oral streptococci exhibit diverse susceptibility to human β‑dedensin‑2: antimicrobial effects of hBD‑2 on oral streptococci. Curr Microbiol. 2004; 48: 85‑87.

64. Abiko Y, Suraweera A, Nishimura M, Taishin TA, Mizoguchi I, Kaku T. Differential expression of human beta‑defensin 2 in keratinized and non‑keratinized oral epithelial lesions: immunohistochemistry and in situ hybridization. Virchows Arch. 2001; 438: 248‑253.

65. Sun CQ, Arnold RS, Hsieh CL, Dorin JR, Lian F, Li Z et al. Discovery and mechanisms of host defense to oncogenesis: targeting the β‑defensin‑1 peptide as a natural tumor inhibitor. Cancer Biol Ther. 2019; 20 (6): 774‑786.