De la Torre A, Carrillo LM, Arciniegas E, Rojas H, Reyes O

Language: Portugués
References: 37
Page: 178-187
PDF size: 747.75 Kb.

ABSTRACT

Introduction: Mucin1 (MUC1) is a transmembrane glycoprotein normally expressed on the apical side of many secretory epithelial cells. It is overexpressed in many carcinomas being considered as molecular sensor and signal transducer in response to external stimuli. However, its possible role in CBC has not been considered. Aim: To ascertain whether MUC1 is present in the epidermal thickening of CBC superficial. Also, to examine the presence and location of NFκBp65, NFκBp50, c- Src, EGFR and ErbB2 in their activated forms in some of these biopsies. Methodology: Eight biopsies of patients diagnosed with superficial BCC were selected. Six samples of normal skin were also examined. The presence of these proteins was assessed by immunofluorescence with a confocal microscope. Results: Immunostaining revealed that MUC1 was present in the epidermal thickening of all biopsies examined. Also, demonstrated that the activated forms of NFκBp65, NFκBp50, IKKα/β, and c-Src were present in these thickened where MUC1 was detected. Additionally, we show that the activated forms of EGFR and ErbB2 were located in the nucleus of many of the thickened epidermal cells. Conclusions: Based on our observations and previous studies, we propose that the stimulation of keratinocytes (by exposure to UV radiation, mechanical damage, growth factors or cytokines) may enable those molecules such as c-Src and IKKα favoring the activation of NFκβ and the eventual expression of MUC1. Once expressed MUC1 would be participating in some cellular responses such as cell proliferation, loss of intercellular junctions, migration and survival of keratinocytes.

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