García‑Galaviz RA, Díaz‑González JM, Cano‑Aguilar LE, Domínguez‑Cherit J

Idioma: Portugués
Referencias bibliográficas: 54
Paginas: 170-177
Archivo PDF: 273.24 Kb.

RESUMEN

La vitamina D es una provitamina liposoluble de la hormona esteroidea 1,25- hidroxivitamina D3 sintetizada en los queratinocitos, producida por vía endógena ante la exposición a los rayos ultravioleta o por vía exógena mediante suplementación. La producción de la vitamina D está determinada por el fototipo de Fitzpatrick, el sexo, el índice de masa corporal y los polimorfismos en el receptor de vitamina D. En épocas anteriores, la vitamina D era considerada una hormona con función exclusivamente relacionada con el metabolismo y la homeostasis del calcio. En la actualidad, ha sido vinculada con diversas patologías de carácter neoplásico, autoinmune, cardiovascular y dermatológico. En el área de la Dermatología, la alteración de la vitamina D desempeña un papel esencial en la etiopatogenia de diferentes dermatosis de carácter inflamatorio y neoplásicas, se encuentra relacionada con la gravedad de presentación, pronóstico a corto y largo plazo, así como recurrencia de éstas. Por lo tanto, conocer las principales dermatosis relacionadas con la alteración en la regulación inmunitaria de la vitamina D es de suma importancia para el manejo y posible suplementación como tratamiento coadyuvante de la enfermedad. Consideramos que la suplementación de vitamina D es útil para mantener la homeostasis celular de la piel.

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