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ISSN 0210-5187 (Electronic)

2019, Number 3

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Med Cutan Iber Lat Am 2019; 47 (3)

Current use of vitamin D in dermatology

García‑Galaviz RA, Díaz‑González JM, Cano‑Aguilar LE, Domínguez‑Cherit J

Language: Portugués
References: 54
Page: 170-177
PDF size: 273.24 Kb.


ABSTRACT

Vitamin D is a liposoluble provitamin of the steroid hormone 1,25-hydroxyvitamin D3 synthesized in keratinocytes, produced by the endogenous route when exposed to UV rays or exogenously by means of supplementation. The production of vitamin D is determined by Fitzpatrick’s phototype, gender, body mass index and polymorphisms in the vitamin D receptor. Previously, it was considered a hormone with function exclusively related to the calcium metabolism and homeostasis. Currently, the role of the hormone has been linked to an increasing number of neoplastic, autoimmune, cardiovascular and dermatological diseases. In Dermatology, altered vitamin D plays an essential role in pathogenesis of different inflammatory and neoplastic dermatoses, it is related to severity, short and long-term prognosis, as well as recurrence of the disease. Therefore, knowing the main dermatological diseases related to altered immune regulation of vitamin D is of utmost importance for the management and possible supplementation as an adjuvant treatment. We consider that Vitamin D supplementation is useful maintaining cell homeostasis of the skin.


REFERENCES

  1. Reichrath J, Saternus R, Vogt T. Endocrine actions of vitamin D in skin: Relevance for photocarcinogenesis of non-melanoma skin cancer, and beyond. Mol Cell Endocrinol. 2017; 453: 96-102.

  2. Holick MF. Vitamin D and bone health. J Nutr. 1996; 126: 1159S-1164S.

  3. Kechichian E, Ezzedine K. Vitamin D and the skin: an update for dermatologists. Am J Clin Dermatol. 2018; 19: 223-235.

  4. Mostafa WZ, Hegazy RA. Vitamin D and the skin: focus on a complex relationship: a review. J Adv Res. 2015; 6: 793-804.

  5. Lim A, Shayan R, Varigos G. High serum vitamin D level correlates with better prognostic indicators in primary melanoma: A pilot study. Australas J Dermatol. 2018; 59:182-187.

  6. Wadhwa B, Relhan V, Goel K, Kochhar AM, Garg VK. Vitamin D and skin diseases: A review. Indian J Dermatol Venereol Leprol. 2015; 81: 344-355.

  7. Adams JS, Ren J, Liu PT, Chun RF, Lagishetty V, Gombart AF et al. Vitamin d-directed rheostatic regulation of monocyte antibacterial responses. J Immunol. 2009; 182: 4289-4295.

  8. Maleki M, Nahidi Y, Azizahari S, Meibodi NT, Hadianfar A. Serum 25-OH vitamin D level in psoriatic patients and comparison with control subjects. J Cutan Med Surg. 2016; 20: 207-210.

  9. Scott JF, Das LM, Ahsanuddin S, Qiu Y, Binko AM, Traylor ZP et al. Oral vitamin D rapidly attenuates inflammation from sunburn: an interventional study. J Invest Dermatol. 2017; 137 (10): 2078-2086.

  10. Scott JF, Lu KQ. Vitamin D as therapeutic option for sunburn: clinical and biologic implications. DNA Cell Biol. 2017; 36: 879-882.

  11. Ingram MA, Jones MB, Stonehouse W, Jarret P, Scragg R, Mugdrige O et al. Oral vitamin D3 supplementation for chronic plaque psoriasis: a randomized, double-blind, placebo-controlled trial. J Dermatol Treat. 2018; 22: 1-10.

  12. Filoni A, Vestita M, Congedo M, Giudice G, Tafuri S, Bonamonte D. Association between psoriasis and vitamin D: Duration of disease correlates with decreased vitamin D serum levels: An observational case-control study. Medicine (Baltimore). 2018; 97 (25): e11185.

  13. Kubin ME, Kokkonen N, Palatsi R, Hagg PM, Vayrynen KP, Haapasaari KM et al. Clinical efficiency of topical calcipotriol/betamethasone treatment in psoriasis relies on suppression of the inflammatory TNFα-IL-23-IL-17 Axis. Acta Derm Venereol. 2017; 97: 449-455.

  14. Al-Dhubaibi MS. Association between vitamin D deficiency and psoriasis: an exploratory study. Int J Health Sci (Qassim). 2018; 12 (1): 33-39.

  15. Umezawa Y, Nakagawa H, Tamaki K. Phase III clinical study of maxacalcitol ointment in patients with palmoplantar pustulosis: a randomized, double-blind, placebo-controlled trial. J Dermatol. 2016; 43 (3): 288-293.

  16. Albenali LH, Danby S, Moustafa M, Brown K, Chittocl J, Shackley F et al. Vitamin D and antimicrobial peptide levels in patients with atopic dermatitis and atopic dermatitis complicated by eczema herpeticum: A pilot study. J Allergy Clin Immunol. 2016; 138: 1725-1719.

  17. Dogru M. Is vitamin D level associated with the natural course of atopic dermatitis? Allergol Immunopathol (Madr). 2018; 46 (6): 546-551.

  18. Vieira BL, Lim NR, Lohman ME, Lio PA. Complementary and alternative medicine for atopic dermatitis: an evidence-based review. Am J Clin Dermatol. 2016; 17: 557-581.

  19. Sethuraman G, Marwaha RK, Challa A, Yenamandra VK, Ramakrishnan L, Thulkar S et al. Vitamin D: a new promising therapy for congenital ichthyosis. Pediatrics. 2016; 137 (1).

  20. Weidner T, Illing T, Miguel D, Elsner P. Treatment of porokeratosis: a systematic review. Am J Clinic Dermatol. 2017; 18: 435-449.

  21. Liang G, Nan H, Qureshi AA, Han J. Pre-diagnostic plasma 25-hydroxyvitamin D levels and risk of non-melanoma skin cancer in women. PLoS One. 2012; 7 (4): e35211.

  22. Cerman AA, Karabay EA, Altunay IK, Cesur SK. Vitamin D levels in actinic keratosis: a preliminary study. An Bras Dermatol. 2018; 93: 535-538.

  23. Cunningham TJ, Tabacchi M, Eliane JP, Tuchayi SM, Manivasagam S, Mirzaalian H et al. Randomized trial of calcipotriol combined with 5-fluorouracil for skin cancer precursor immunotherapy. J Clin Invest. 2016; 127 (1): 106-116.

  24. Orlow I, Reiner AS, Thomas NE, Roy P, Kanetsky PA, Luo L et al. Vitamin D receptor polymorphism and survival in patients with cutaneous melanoma: a population- based study. Carcinogenesis. 2016; 37: 30-38.

  25. Paolino G, Panetta C, Cota C, Didona D, Moliterni E, Di Mattia C et al. Vitamin D receptor immunohistochemistry variability in sun-exposed and non-sun-exposed melanomas. Melanoma Res. 2017; 27: 17-23.

  26. Wyatt C, Lucas RM, Hurst C, Kimlin MG. Vitamin D deficiency at melanoma diagnosis is associated with higher Breslow thickness. PLoS One. 2015; 10 (5): e0126394.

  27. Cattaruzza MS, Pisani D, Fidanza L, Gandini S, Marmo G, Narcisi A et al. 25-Hydroxivitamin D serum levels and melanoma risk: a case control study and evidence synthesis of clinical epidemiological studies. Eur J Cancer Prev. 2019; 28 (3): 203-211.

  28. Slominski AT; Brozyna AA, Skobowiat C, Zmijewski MA, Kim TK, Janjetovic Z et al. On the role of classical and novel forms of vitamin D in melanoma progression and management. J Steroid Biochem Mol Biol. 2018; 177: 159-170.

  29. Woo YR, Jung KE, Koo DW, Lee JS. Vitamin D as a marker for disease severity in chronic urticaria and its possible role in pathogenesis. Ann Dermatol. 2015; 27 (4): 423-430.

  30. Goetz DW. Idiopathic itch, rash, and urticaria/angioedema merit serum vitamin D evaluation: a descriptive case series. W V Med J. 2011; 107 (1): 14-20.

  31. Rather S, Keen A, Sajad P. Serum levels of 25-hydroxyvitamin D in chronic urticaria and its association with disease activity: a case control study. Indian Dermatol Online J. 2018; 9: 170-174.

  32. Aktas H, Ergin C, Demir B, Ekiz O. Intralesional vitamin D injection may be an effective treatment option for warts. J Cutan Med Surg. 2016; 20: 118-122.

  33. Hersh AO, Arkin LM, Prahalad S. Immunogenetics of cutaneous lupus erythematosus. Curr Opin Pediatr. 2016; 28: 470-475.

  34. García M, Mendoza C, Etchegaray I, Soto P, Jiménez E, Robles V et al. Insuficiencia y deficiencia de vitamina D en pacientes mexicanas con lupus eritematoso sistémico: prevalencia y relación con actividad de la enfermedad. Reumatol Clin. 2017; 13: 97-101.

  35. Cutillas-Marco E, Marquina-Vila A, Grant WB et al. Vitamin D and cutaneous lupus erythematosus: effect of vitamin D replacement on disease severity. Lupus. 2014; 23 (7): 615-623.

  36. Chang J, Weth VP. Therapeutic options for cutaneous lupus erythematosus: recent advances and future prospects. Expert Rev Clin Immunol. 2017; 12: 1009-1021.

  37. Mok CC, Bro ET, Ho LY, Singh RJ, Jannetto PJ. Serum 25-hydroxyvitamin D3 levels and flares of systemic lupus erythematosus: a longitudinal cohort analysis. Clin Rheumatol. 2018; 37 (10): 2685-2692.

  38. Aly D, Mohammed F, Sayed K, Gawdat H, Mashaly H, Abdel Hay R et al. Is there a relation between vitamin D and interleukin-17 in vitiligo? A cross-sectional Study. Dermatology. 2017; 233: 413-418.

  39. Doss RW, El-Rifaie AA, Gohary YM, Rashed LA. Vitamin D receptor expression in vitiligo. Indian J Dermatol. 2015; 60: 544-548.

  40. Tomita Y, Torinuki W, Tagami H. Stimulation of human melanocytes by vitamin D3 possibly mediates skin pigmentation after sun exposure. J Invest Dermatol. 1988; 90: 882e4.

  41. Karagüzel G, Sakarya NP, Bahadir S, Yaman S, Okten A. Vitamin D status and the effects of oral vitamin D treatment in children with vitiligo: A prospective study. Clin Nutr. 2016; 15: 28-31.

  42. Rasheed H, Hegazy RA, Gawdat HI, Mehaney DA, Kamel MM, Fawzy MM et al. Serum vitamin D and vitamin d receptor gene polymorphism in mycosis fungoides patients: a case control study. PLoS One. 2016; 11 (6): e0158014.

  43. Xie Z, Komuves L, Yu QC et al. Lack of the vitamin D receptor is associated with reduced epidermal differentiation and hair follicle growth. J Invest Dermatol. 2002; 118: 11-16.

  44. Rossi A, Miraglia E, Fortuna MC, Calvieri S, Giustini S. Topical cetirizine and oral vitamin D: A valid treatment for hypotrichosis caused by ectodermal dysplasia. J Eur Acad Dermatol Venereol. 2017; 31: 367-370.

  45. Lim SK, Ha JM, Lee YH, Lee Y, Seo YJ, Kim CD et al. Comparison of vitamin D levels in patients with and without acne: a case-control study combined with a randomized controlled trial. PLoS One. 2016; 11 (8): e0161162.

  46. El-Hamd MA, El Taieb MA, Ibrahim HM, Aly SS. Vitamin D levels in acne vulgaris patients treated with oral isotretinoin. J Cosmet Dermatol. 2019; 18 (1): 16-20.

  47. Rasheed H, Mahgoub D, Hegazy R, El-Komy M, Abdel Hay R, Hamid MA et al. Serum ferritin and vitamin D in female hair loss: do they play a role? Skin Pharmacol Physiol. 2013; 26: 101-107.

  48. Banihashemi M, Nahidi Y, Meibodi NT, Jarah L, Dolatkhah M. Serum vitamin D3 level in patients with female pattern hair loss. Int J Trichology. 2016; 8: 116-120.

  49. Unal M, Gonulalan G. Serum vitamin D level is related to disease severity in pediatric alopecia areata. J Cosmet Dermatol. 2018; 17: 101-104.

  50. Gade VKV, Mony A, Munisamy M, Chandrashekar L, Rajappa M. An investigation of vitamin D status in alopecia areata. Clin Exp Med. 2018; 18 (4): 577-584.

  51. Lee S, Kim BJ, Lee CH, Lee WS. Increased prevalence of vitamin D deficiency in patients with alopecia areata: a systematic review and meta-analysis. J Eur Acad Dermatol Venereol. 2018; 32: 1214-1221.

  52. Razzaghi R, Pourbagheri H, Momen-Heravi M, Bahmani F, Shadi J, Soleimani Z et al. The effects of vitamin D supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double-blind, placebo-controlled trial. J Diabetes Complications. 2017; 31 (4): 766-772.

  53. Fledkamo J, Jungheim K, Schott M, Jacobs B, Roden M. Severe vitamin D3 deficiency in the majority of patients with diabetic foot ulcers. Hom Metab Res. 2018; 50: 615-619.

  54. Kim EW, Teles RMB, Haile S, Liu PT, Modlin RL. Vitamin D status contributes to the antimicrobial activity of macrophages against Mycobacterium leprae. PLoS Negl Trop Dis. 2018; 12 (7): e0006608.




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