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Órgano Oficial del Colegio Mexicano de Alergia, Asma e Inmunología Pediátrica y de la Asociación Latinoamericana de Pediatría

2019, Number 3

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Alerg Asma Inmunol Pediatr 2019; 28 (3)

Taste receptors in airways. Its importance in nasosinusal homeostasis

Sacre-Hazouri JA,Sacre L

Language: Spanish
References: 81
Page: 88-95
PDF size: 207.40 Kb.


ABSTRACT

The immune system acts as a sensory system to detect invading pathogens. Recent evidence suggests that the immune and taste systems utilize some of the same chemosensory receptors, namely bitter taste receptors of the taste receptor family 2 (T2R). T2Rs are G-protein coupled receptors originally identified in type 2 taste receptor cells of the tongue, but expression of these T2Rs is now known to extend to multiple organ systems, including the airway. Basic science and clinical studies are establishing T2Rs as part of a novel pathogen detection network in the airway, they are expressed in a variety of airway cell types and regulate multiple innate immune responses in both mice and humans. The T2R isoform, taste receptor family 2 isoform 38 protein (T2R38), which is expressed in motile cilia lining the sinonasal cavity (nose and sinuses), has recently been linked with sinonasal innate immunity, upper respiratory infection and chronic rhinosinusitis (CRS) demonstrating their importance into human disease and these very frequent diseases.


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