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Órgano Oficial del Colegio Mexicano de Alergia, Asma e Inmunología Pediátrica y de la Asociación Latinoamericana de Pediatría

2019, Número 3

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Alerg Asma Inmunol Pediatr 2019; 28 (3)


Receptores del gusto en la vía respiratoria. Su importancia en homeostasis nasosinusal

Sacre-Hazouri JA,Sacre L

Idioma: Español
Referencias bibliográficas: 81
Paginas: 88-95
Archivo PDF: 207.40 Kb.


RESUMEN

El sistema inmune actúa como un sistema sensorial detectando patógenos invasores. Evidencia reciente sugiere que el sistema inmune y el sistema del gusto utilizan algunos de los mismos receptores quimiosensoriales, la familia 2 de los receptores del gusto amargos (T2R). T2R son receptores acoplados a la proteína G originalmente identificados en las células tipo 2 del gusto en la lengua; sin embargo, la expresión de éstos se sabe se extienden a múltiples órganos y sistemas, incluyendo la vía respiratoria. Estudios básicos y clínicos han demostrado que estos T2Rs son parte de una vía de reconocimiento de patógenos en la vía respiratoria y regulan respuestas innatas múltiples tanto en ratones como en humanos. Se ha encontrado que la isoforma T2R38 (familia 2 del receptor del gusto isoforma 38), la cual se expresa en los cilios móviles que se encuentran en la nariz y senos paranasales, se relaciona de manera importante a la inmunidad innata nasosinusal, a la respuesta a infecciones respiratorias superiores y a la rinosinusitis crónica. Esto nos abre un camino potencial de entender mejor estas patologías muy frecuentes.


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