medigraphic.com
ISSN 1561-3011 (Electronic)

2018, Number 4

<< Back Next >>

Rev Cubana Invest Bioméd 2018; 37 (4)

Neuroimmunological study in patients with spastic paraparesis

González LC, Dorta CAJ

Language: Spanish
References: 25
Page: 1-9
PDF size: 185.21 Kb.


ABSTRACT

Introduction: Spastic paraparesis is a neurological disorder that according to its etiology can be classified in different ways: progressive spinal paraparesis, hepatic spinal paraparesis or tropical spastic paraparesis.
Objective: To characterize the neuroimmunological response, evaluated by reibergram, in patients with spastic paraparesis.
Methods: A retrospective study was conducted in 2017, where the occurrence of intrathecal synthesis of major immunoglobulins and the status of the blood / CSF barrier in patients with spastic paraparesis was evaluated. We worked with an intentional sample of 20 patients according to the inclusion and exclusion criteria, from the LABCEL serrachokary and, retrospectively, two groups of patients were formed: 7 pediatric patients and 13 adults. The levels of albumin, IgA, IgG and IgM were quantified by immunochemical nephelometry with kinetic analysis. The reibergram was used to evaluate the occurrence of intrathecal synthesis and the status of the blood/CSF barrier.
Results: All patients presented intrathecal synthesis of at least one of the major immunoglobulin classes. The most common synthesis patterns are those of two and three classes. The immunoglobulin that was most synthesized was IgM. All pediatric patients showed hundreds of high intrathecal IgM synthesis. The barrier dysfunction only occurred in two cases, one pediatric and the other adult.
Conclusions: Inflammatory process of the central nervous system is noticed in all patients.


REFERENCES

  1. González-Losada C, Dorta-Contreras AJ. Paraparesia espástica tropical vista desde un contexto ibérico. Rev Neurol. 2016;62:143-4.

  2. Citterio A, Arnoldi A, Panzeri E, D'Angelo MG, Filosto M, Dilena R, et al. Mutations in CYP2U1, DDHD2 and GBA2 genes are rare causes of complicated forms of hereditary spastic paraparesis. J Neurol. 2014;261(2):373-81.

  3. Oz-Levi D, Ben-Zeev B, Ruzzo EK, Hitomi Y, Gelman A, Pelak K, et al. Mutation in TECPR2 reveals a role for autophagy in hereditary spastic paraparesis. Am J Hum Genet. 2012;91(6):1065-72.

  4. Pías-Peleteiro L, Pías-Peleteiro JM, Arias M. Paraparesia espástica tropical en una región no tropical. Rev Neurol. 2015;61: 357-62.

  5. Vásquez PT. HTLV-I (Human T- cell lymphotropic virus), algo que decir? Rev. chil. infectol. 2003 [citado 5 abr 2017];20(1):34-37. Disponible en: http://dx.doi.org/10.4067/S0716-10182003020100005

  6. Díaz Torres H, Álvarez Vega N, Muñío Perurena J, Lubián Caballero A, Martín Alfonso D, Díaz Herrera D, et al. [Human T-cell lymphotropic virus type I infection in patients with lymphoproliferative disorders at two sentinel sites in Cuba]. Rev Panam Salud Publica. 2010;1(27):17-22.

  7. Rolo Gómez F, De Armas M, Mato Luis J, Lubián Caballero A, Díaz Torres H. Confirmation of the presence in Cuba of human T-cell lymphotropic virus type I using the polymerase chain reaction. Rev Cubana Med Trop. 1997;49(3):204-8.

  8. Machado L, Navea L, Díaz H, Blanco M, Dubed M, Romay D, et al. Phylogenetic analysis of human T cell lymphotropic virus type 1 isolated from Cuban individuals. AIDS Res Hum Retroviruses. 2013;29(8):1168-72.

  9. Navea LeyvaI L, Dubed Echevarría M, Álvarez Seguí G, Blanco de Armas M, Díaz Herrera F, Santos Beguerías R, et al. Aislamiento del virus linfotrópico de células T humano tipo I de un paciente con paraparesia espástica tropical: primer reporte en Cuba. Rev Cubana Med Trop [Internet]. [citedo 2014 20 marzo];60(2):[Aprox 5 p.]. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0375- 07602008000200015&lng=es&nrm=iso&tlng=es

  10. Kasper DL, Hauser SL, Jameson JL, Fauci AS, Longo DL，Loscalzo J, editores. En: Harrison. Principios de Medicina Interna. New York: McGraw-Hill Education; 2015. ISBN: 978-0-07-1 8021 6- 1

  11. Reiber H. Knowledge-base for interpretation of cerebrospinal fluid data patterns. Essentials in neurology and psychiatry. Arq Neuropsiquiatr. 2016;74(6):501-12.

  12. Reiber H. Cerebrospinal fluid data compilation and knowledge-based interpretation of bacterial, viral, parasitic, oncological, chronic inflammatory and demyelinating diseases. Diagnostic patterns not to be missed in neurology and psychiatry. Arq Neuropsiquiatr. 2016;74(4):337-50.

  13. Wildemann B, Oschmann P, Reiber H. Laboratory diagnosis in Neurology. Stuttgart: Thieme; 2010.

  14. Bárbara Padilla-Docal B, Dorta-Contreras AJ, Reiber H, Iglesias-González IM, Jensenius JC, González-Losada C, et al. Marcadores moleculares de la meningoencefalitis eosinofílica por Angiostrongylus cantonensis. En: Martini Robles L, Dorta Contreras AJ, editores. Angiostrongylus cantonensis. Emergencia en América. La Habana: Academia; 2016. 18-56. ISBN 978-959-270-368-1

  15. Reiber H. Flow rate of cerebrospinal fluid (CSF): a concept common to normal blood-CSF barrier function and to dysfunction in neurological diseases. J Neurol Sci. 1994;122:189-203.

  16. Dorta Contreras AJ, Reiber H. Teoría de la difusión molecular/flujo del líquido cefalorraquídeo. Rev Neurol. 2004;39:564-9.

  17. Dorta Contreras A. Reibergramas: elemento esencial en el análisis inmunológico del líquido cefalorraquídeo. Rev Neurol. 2000;28:996-8.

  18. Dorta Contreras AJ. Reibergrama como herramienta epidemiológica: nuevo enfoque. Rev Neurol. 2001;33:36.

  19. Dorta-Contreras AJ. Pattern of intrathecal immunoglobulin synthesis in pediatric patients with infectious meningoencephalitis. Biotecnol Apl. 2006;4:382-6.

  20. Padilla-Docal B, Dorta-Contreras AJ, Bu Coifiu-Fanego R, Noris-García E, Fundora- Hernández H, Callol-Barroso J, et al. Síntesis intratecal de C3c e inmunoglobulinas en niños con meningoencefalitis bacteriana. VacciMonitor. 2008;17:1-5.

  21. Padilla-Docal B, Iglesias-Gonzalez IM, Martinez-Larrarte JP, González-Losada C, Dorta-Contreras AJ. Proceso neuroinflamatorio en pacientes con virus del dengue. Rev Neurol. 2017;64(4):188-90.

  22. Dorta Contreras AJ, Agüero Valdés E, Escobar Pérez X, Noris García E, Ferrá Valdés M. Respuesta inmune humoral intratecal en pacientes pediátricos con meningoencefalitis por coxsackie B 5. Rev Neurol. 1999;28:739-41.

  23. Noris García E, Isidrón Marcelo G, Dorta-Contreras AJ, Valdés Puig EL, Padilla- Docal B, Orta Ceballos G, et al. Neuroinmunología de la meningoencefalitis por citomegalovirus en pacientes inmunocompetentes. Rev Cubana Med. 2006;45(4):1-6.

  24. Dorta Contreras AJ, Padilla Docal B, Moreira JM, Martini Robles L, Muzzio Aroca J, Alarcón F, et al. Neuroimmunological findings of Angiostrongylus cantonensis meningitis in Ecuadorian patients. Arq Neuropsiquiatr. 2011;69(3):466-9.

  25. Ballester JM. El Programa de Medicina Transfusional de Cuba. Rev Panam Salud Pública. 2003;13(2-3):160-4.




2020     |     www.medigraphic.com