medigraphic.com
ISSN 2395-9215 (Print)
Órgano Oficial de Difusión de la Facultad de Odontología de la UNAM

2019, Number 2

<< Back Next >>

Rev Mex Ortodon 2019; 7 (2)

Dental anomalies in the non cleft side of children with non syndromic unilateral cleft lip and palate

Yezioro RS, Rengifo RHA, Aguilar MD

Language: Spanish
References: 30
Page: 57-65
PDF size: 206.34 Kb.


ABSTRACT

Background: Cleft lip and cleft palate are the most common craniofacial congenital malformations. They reflect a failure of mechanisms related to embryological development of the face and palatine processes, suggesting that certain genetic mutations involved in the formation of the cleft palate also produce alterations in the dental lamina. Objective: We aimed to determine the frequency, type, and risk of dental anomalies in the normal maxillary side of children with non syndromic unilateral cleft lip and palate (UCLP). Methods: This is an observational, case-control analytical study. Panoramic radiographs of 336 children aged six to 12 years old (111 cases and 225 controls) were analyzed. The following dental anomalies were identified: agenesis, supernumerary teeth, microdontia of lateral incisors, taurodontism, transposition, impaction, and rotation of central incisors. A bivariate analysis was performed using χ2 and Fischer tests, and conditional logistic regression with fixed effects was done to calculate risk estimators. Results: In total, 48.6% of children in the UCLP group and 36% in the control group had at least one dental anomaly. The most common defect was agenesis of maxillary lateral incisors and second premolars with significant differences (p = 0.00). Children with UCLP were 3 times more likely to have dental anomalies than healthy children (OR 2.9; 95% CI [1.4-6.0]; p = 0.002). Conclusions: We found a higher prevalence and risk of dental anomalies in the noncleft side of children with UCLP than in children without this condition.


REFERENCES

  1. Tannure PN, Oliveira CA, Maia LC, Vieira AR, Granjeiro JM, Costa Mde C. Prevalence of dental anomalies in nonsyndromic individuals with cleft lip and palate: a systematic review and meta-analysis. Cleft Palate Craniofac J. 2012; 49 (2): 194-200.

  2. Küchler EC, Da Motta LG, Vieira AR, Granjeiro JM. Side of dental anomalies and taurodontism as potential clinical markers for cleft subphenotypes. Cleft Palate Craniofac J. 2011; 48 (1): 103-108.

  3. Dixon MJ, Marazita ML, Beaty TH, Murray JC. Cleft lip and palate: understanding genetic and environmental influences. Nat Rev Genet. 2011; 12 (3): 167-178.

  4. Letra A, Menezes R, Granjeiro JM, Viera AR. Defining subphenotypes for oral clefts based on dental development. J Dent Res. 2007; 86 (10): 986-991.

  5. Menezes R, Vieira AR. Dental anomalies as part of the cleft spectrum. Cleft Palate Craniofac J. 2008; 45 (4): 414-419.

  6. Paranaiba LMR. Prevalence of dental anomalies in patients with nonsyndromic cleft lip and/or palate in a Brazilian population. Cleft Palate-Craniofac J. 2013; 50: 400-405.

  7. Shapira Y, Lubit E, Kuftinec MM. Hypodontia in children with various types of clefts. Angle Orthod. 2000; 70 (1): 16-21.

  8. Slayton RL, Williams L, Murray JC, Wheeler JJ, Lidral AC NC. Slayton RL et al. Genetic association studies of cleft lip and/or palate with hypodontia outside the cleft region. Cleft Palate-Craniofacial J. 2003; 40 (3): 274-279.

  9. Garib DG, Alencar BM, Lauris JR, Baccetti T. Agenesis of maxillary lateral incisors and associated dental anomalies. Am J Orthod Dentofacial Orthop. 2010; 137 (6): 1-6.

  10. Howe BJ, Cooper ME, Vieira AR, Weinberg SM, Resick JM, Nidey NL et al. Spectrum of dental phenotypes in nonsyndromic orofacial clefting. J Dent Res. 2015; 94 (7): 905-912.

  11. Mossey PA, Little J, Munger RG, Dixon MJ SW. Cleft lip and palate. Lancet. 2009; 374 (9703): 1773-1785.

  12. Tortora C, Meazzini MC, Garattini G, Brusati R. Prevalence of abnormalities in dental structure, position, and eruption pattern in a population of unilateral and bilateral cleft lip and palate patients. Cleft Palate Craniofac J. 2008; 45 (2): 154-162.

  13. Ziak P, Fedeles J Jr, Fekiacova D, Hulin I Jr FJ. Timing of primary lip repair in cleft patients according to surgical treatment protocol. Bratisl Lek List. 2010; 111 (3): 160-162.

  14. Akcam MO, Evirgen S, Ozge Uslu and UTM. Dental anomalies in individuals with cleft lip and/or palate. Eur J Orthod. 2010; 32 (2): 207-213.

  15. Lekkas C, Latief BS, Ter Rahe SP, Kuijpers-Jagtman AM. The adult unoperated cleft patient: absence of maxillary teeth outside the cleft area. Cleft Palate Craniofac J. 2000; 37 (1): 17-20.

  16. Pegelow M, Alqadi N, Karsten AL. The prevalence of various dental characteristics in the primary and mixed dentition in patients born with non-syndromic unilateral cleft lip with or without cleft palate. Eur J Orthod. 2012; 34 (5): 561-570.

  17. De Lima Pedro R, Faria MD, de Costa M, Vieira AR. Dental anomalies in children born with clefts: a case-control study. Cleft Palate Craniofac J. 2012; 49 (6): 64-68.

  18. Ministerio Nacional de Salud. IV Estudio Nacional de Salud Bucal. Bogotá, Colombia, Ministerio Nacional de Salud; 2014.

  19. Rengifo-Reina HA. Caracterización dental de niños colombianos con hendiduras labio palatinas no sindrómicas. Rev Odont Mex. 2016; 20 (3): 179-186.

  20. Thesleff I. The genetic basis of tooth development and dental defects. Am J Med Genet. 2006; part A (140A): 2530-2535.

  21. Jafarzadeh H, Azarpazhooh A, Mayhall JT. Taurodontism: a review of the condition and endodontic treatment challenges. Int Endod J. 2008; 41 (5): 375-388.

  22. Celikoglu, Mevlut, Ozkan Miloglu and OO. Investigation of tooth transposition in a non-syndromic Turkish anatolian population: characteristic features and associated dental anomalies. Med Oral Patol Oral Cir Bucal. 2010; 15 (5): 716-720.

  23. Juodzbalys G, Daugela P. Mandibular third molar impaction: review of literature and a proposal of a classification. J Oral Maxillofac Res. 2013; 4 (2): 1-11.

  24. Gupta SK, Saxena P, Jain S. Prevalence and distribution of selected developmental dental anomalies in an Indian population. J Oral Sci. 2011; 53 (2): 231-238.

  25. Dewinter G, Quirynen M, Heidbüchel K, Verdonck A, Willems G, Carels C. Dental abnormalities, bone graft quality, and periodontal conditions in patients with unilateral cleft lip and palate at different phases of orthodontic treatment. Cleft Palate Craniofac J. 2003; 40 (4): 343-350.

  26. Stahl F, Grabowski R, Wigger K. Epidemiology of Hoffmeister’s “genetically determined predisposition to disturbed development of the dentition” in patients with cleft lip and palate. Cleft Palate Craniofac J. 2006; 43 (4): 457-465.

  27. Dentino KM, Peck S, Garib DG. Is missing maxillary lateral incisor in complete cleft lip and palate a product of genetics or local environment? Angle Orthod. 2012; 82 (6): 959-963.

  28. Lourenço Ribeiro L, Teixeira Das Neves L, Costa B, Ribeiro Gomide M. Dental anomalies of the permanent lateral incisors and prevalence of hypodontia outside the cleft area in complete unilateral cleft lip and palate. Cleft Palate-Craniofac J. 2003; 40 (2): 172-175.

  29. Becker A, Chaushu S. Etiology of maxillary canine impaction: a review. Am J Orthod Dentofac Orthop. 2015; 148: 557-567.

  30. Seo YJ, Park JW, Kim YH, Baek SH. Associations between the risk of tooth agenesis and single-nucleotide polymorphisms of MSX1 and PAX9 genes in nonsyndromic cleft patients. Angle Orthod. 2013; 83 (6): 1036-1042.




2020     |     www.medigraphic.com