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2006, Number 1

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Rev Inst Nal Enf Resp Mex 2006; 19 (1)

Tuberculosis and AIDS in Cuba. A study of two series of cases

Reyes CA, Capó de PV, Díaz JM, Pérez ÁJ, Bouza JY

Language: Spanish
References: 48
Page: 16-27
PDF size: 88.00 Kb.


ABSTRACT

Objective: Analysis of groups of patients with the acquired immunodeficiency syndrome (AIDS) and tuberculosis (TB) diagnosed before and after the use of highly active anti-retroviral therapy (HAART) in Cuba.
Methods: Chart analysis of 149 cases with AIDS and TB. Series I, 72 cases (January 1997-March 2001, before HAART). Series II, 77 cases (May 2001-June 2004, after HAART); all the patients were discharged from the "Instituto de Medicina Tropical ‘Pedro Kourí " in Havana, Cuba.
Results and conclusions: There was a predominance of young (30-33ys) males in both series; 58.3% and 57.1% of cases classified as AIDS at the appearance of TB; TB was the first indicator of AIDS in 64.9% of cases in Series II; 54.5% of cases in Series II and 36.4% in Series I had ‹ 200 CD4+TL cells, probably related to better immunologic status. Clinical profile was similar; fever of uknown origin, nocturnal sweats, dyspnea and regional lymphadenopathies were more frequent in Series II. Amongst TB cases, pulmonary disease was more frequent (79.2% and 75.3%, respectively); 9 cases (11.7%) of Series II had disseminated TB.
Diffuse basal and mediastinal shadows and negative chest X rays were more frequent; there was no correlation between the counts of CD4+ TL cells and the clinical and radiological forms of TB. Series II had a lower invadence of positive sputum smearsand positive cultures and a higher incidence of positive intradermal reaction to tuberculin and positive tissue diagnoses for TB.


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